Back to Search
Start Over
Sexual dimorphism in neurobehavioural phenotype and gut microbial composition upon long-term exposure to structural analogues of bisphenol-A.
- Source :
-
Journal of hazardous materials [J Hazard Mater] 2024 Sep 05; Vol. 476, pp. 135178. Date of Electronic Publication: 2024 Jul 10. - Publication Year :
- 2024
-
Abstract
- Bisphenol S (BPS) and Bisphenol F (BPF), the analogues of the legacy endocrine disrupting chemical, Bisphenol A (BPA) are ubiquitous in the environment and present in various consumer goods, and potentially neurotoxic. Here, we studied sex-specific responses of bisphenols on behavioural phenotypes, including their association with pro-inflammatory biomarkers and altered neurotransmitters levels, and the key gut microbial abundances. Neurobehavioural changes, using standard test battery, biochemical and molecular estimations for inflammatory cytokines, neurotransmitters, and oxido-nitrosative stress markers, gene expression analysis using qRT-PCR, H&E based histological investigations, gut permeability assays and Oxford Nanopore-based 16S-rRNA metagenomics sequencing for the gut microbial abundance estimations were performed. Bisphenol(s) exposure induces anxiety and depression-like behaviours, particularly in the male mice, with heightened pro-inflammatory cytokines levels and systemic endotoxemia, altered monoamine neurotransmitters levels/turnovers and hippocampal neuronal degeneration and inflammatory responses in the brain. They also increased gut permeability and altered microbial diversity, particularly in males. Present study provides evidence for sex-specific discrepancies in neurobehavioural phenotypes and gut microbiota, which necessitate a nuanced understanding of sex-dependent responses to bisphenols. The study contributes to ongoing discussions on the multifaceted implications of bisphenols exposure and underscores the need for tailored regulatory measures to mitigate potential health risks associated with them.<br />Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Male
Female
Cytokines metabolism
Phenotype
Mice
Mice, Inbred C57BL
Anxiety chemically induced
Depression chemically induced
Hippocampus drug effects
Hippocampus metabolism
Neurotransmitter Agents metabolism
Brain drug effects
Brain metabolism
Phenols toxicity
Gastrointestinal Microbiome drug effects
Benzhydryl Compounds toxicity
Sex Characteristics
Sulfones toxicity
Endocrine Disruptors toxicity
Behavior, Animal drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1873-3336
- Volume :
- 476
- Database :
- MEDLINE
- Journal :
- Journal of hazardous materials
- Publication Type :
- Academic Journal
- Accession number :
- 39002480
- Full Text :
- https://doi.org/10.1016/j.jhazmat.2024.135178