1. Diet and myocardial infarction: a nested case-control study in a cohort of elderly subjects in a Mediterranean area of southern Italy.
- Author
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Pierucci P, Misciagna G, Ventura MT, Inguaggiato R, Cisternino AM, Guerra VM, Suppressa P, Resta F, and Sabbà C
- Subjects
- Aged, Case-Control Studies, Cohort Studies, Dietary Carbohydrates administration & dosage, Dietary Carbohydrates adverse effects, Dietary Fats administration & dosage, Fatty Acids, Unsaturated administration & dosage, Female, Follow-Up Studies, Glycemic Index, Humans, Incidence, Italy epidemiology, Male, Mediterranean Region epidemiology, Middle Aged, Motor Activity, Myocardial Infarction etiology, Odds Ratio, Risk Factors, Surveys and Questionnaires, Diabetes Complications epidemiology, Diet, Myocardial Infarction epidemiology
- Abstract
Background and Aim: We evaluated the incidence of myocardial infarction (MI) in a population of Southern Italy and the relationship of dietary macronutrients with incident MI., Methods and Results: The ONCONUT cohort included 5632 subjects followed-up, over 50 years, recruited in 1992. At baseline, they completed a validated semi-quantitative food frequency questionnaire and gave details of their medical history. After 5years they were traced by their family physician, who found 108 incident MI. Ninety-seven of them and 194 controls, sampled from the noncases at baseline and paired for diabetes to the cases, entered this nested case-control study. MI rate per 1000 person-years was 9.6 in males and 3.7 in females. In non-diabetics, saturated fat were associated with MI directly (odds ratio (OR): tertile 2 vs. 1 = 2.32, tertile 3 vs. 1 = 2.82; chi-square for trend, p = 0.03) and polyunsaturated fats inversely (OR: tertile 2 vs. 1 = 0.80, tertile 3 vs. 1 = 0.37; chi-square for trend, p = 0.05), while in diabetics, starchy carbohydrates (OR: tertile 2 vs. 1 = 1.51, tertile 3 vs. 1 = 6.73; chi-square for trend, p = 0.01) and glycaemic index (OR: tertile 2 vs. 1 = 2.74, tertile 3 vs. 1 = 5.34; chi-square for trend, p = 0.01) were associated directly with MI., Conclusions: MI incidence in this population was lower than that found in northern countries. In non-diabetics, saturated fats were associated directly and polyunsaturated fat inversely with MI; in diabetics, starchy carbohydrates and high-glycaemic-index foods were associated directly with MI., (Copyright © 2010 Elsevier B.V. All rights reserved.)
- Published
- 2012
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