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Diet and myocardial infarction: a nested case-control study in a cohort of elderly subjects in a Mediterranean area of southern Italy.
- Source :
-
Nutrition, metabolism, and cardiovascular diseases : NMCD [Nutr Metab Cardiovasc Dis] 2012 Sep; Vol. 22 (9), pp. 727-33. Date of Electronic Publication: 2011 Apr 08. - Publication Year :
- 2012
-
Abstract
- Background and Aim: We evaluated the incidence of myocardial infarction (MI) in a population of Southern Italy and the relationship of dietary macronutrients with incident MI.<br />Methods and Results: The ONCONUT cohort included 5632 subjects followed-up, over 50 years, recruited in 1992. At baseline, they completed a validated semi-quantitative food frequency questionnaire and gave details of their medical history. After 5years they were traced by their family physician, who found 108 incident MI. Ninety-seven of them and 194 controls, sampled from the noncases at baseline and paired for diabetes to the cases, entered this nested case-control study. MI rate per 1000 person-years was 9.6 in males and 3.7 in females. In non-diabetics, saturated fat were associated with MI directly (odds ratio (OR): tertile 2 vs. 1 = 2.32, tertile 3 vs. 1 = 2.82; chi-square for trend, p = 0.03) and polyunsaturated fats inversely (OR: tertile 2 vs. 1 = 0.80, tertile 3 vs. 1 = 0.37; chi-square for trend, p = 0.05), while in diabetics, starchy carbohydrates (OR: tertile 2 vs. 1 = 1.51, tertile 3 vs. 1 = 6.73; chi-square for trend, p = 0.01) and glycaemic index (OR: tertile 2 vs. 1 = 2.74, tertile 3 vs. 1 = 5.34; chi-square for trend, p = 0.01) were associated directly with MI.<br />Conclusions: MI incidence in this population was lower than that found in northern countries. In non-diabetics, saturated fats were associated directly and polyunsaturated fat inversely with MI; in diabetics, starchy carbohydrates and high-glycaemic-index foods were associated directly with MI.<br /> (Copyright © 2010 Elsevier B.V. All rights reserved.)
- Subjects :
- Aged
Case-Control Studies
Cohort Studies
Dietary Carbohydrates administration & dosage
Dietary Carbohydrates adverse effects
Dietary Fats administration & dosage
Fatty Acids, Unsaturated administration & dosage
Female
Follow-Up Studies
Glycemic Index
Humans
Incidence
Italy epidemiology
Male
Mediterranean Region epidemiology
Middle Aged
Motor Activity
Myocardial Infarction etiology
Odds Ratio
Risk Factors
Surveys and Questionnaires
Diabetes Complications epidemiology
Diet
Myocardial Infarction epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1590-3729
- Volume :
- 22
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Nutrition, metabolism, and cardiovascular diseases : NMCD
- Publication Type :
- Academic Journal
- Accession number :
- 21482083
- Full Text :
- https://doi.org/10.1016/j.numecd.2010.12.002