1. Markers of bone remodeling in neoplastic and bone-related lesions.
- Author
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Elias LS, Costa RF, Carvalho MA, Batista AC, Silva TA, Leles CR, and Mendonça EF
- Subjects
- Adolescent, Adult, Biomarkers analysis, Biomarkers, Tumor analysis, Bone Matrix pathology, Bone Resorption physiopathology, Child, Female, Fibroblasts pathology, Fibroma, Ossifying pathology, Fibrous Dysplasia of Bone pathology, Giant Cells pathology, Granuloma, Giant Cell pathology, Humans, Jaw Cysts pathology, Male, Middle Aged, Osteoblasts pathology, Osteoclasts pathology, Osteogenesis physiology, Osteosarcoma pathology, Stromal Cells pathology, Young Adult, Bone Remodeling physiology, Jaw Diseases pathology, Jaw Neoplasms pathology, Osteocalcin analysis, Osteoprotegerin analysis, RANK Ligand analysis, Receptor Activator of Nuclear Factor-kappa B analysis
- Abstract
Objective: The aim of this study was to investigate the expression of bone resorption (RANK/RANKL), bone resorption inhibitor (osteoprotererin [OPG]), and bone formation marker (osteocalcin [OC]) in neoplastic and bone-related lesions (BRL)., Study Design: Using immunohistochemistry, their expression was evaluated in ossifying fibroma (OF), fibrous dysplasia (FD), simple bone cysts (SBC), central giant cell lesions (CGCL), and osteosarcoma (OS)., Results: Quantitative analyses of the expression of bone markers between all lesions, considering fibroblast-like cells and bone matrix, showed that RANK-RANKL presented higher expression in OF and CGCL, whereas OPG and OC presented higher expression in FD and SBC. There was higher expression of all proteins investigated when OS was the BRL. Moreover, the RANKL expression was greater than OPG in this neoplasm., Conclusion: Our data indicate that the bone resorption markers are more highly expressed in OF, CGCL, and OS than in FD and SBC, indicating a significant association between these proteins and the clinical behavior of these lesions., (Copyright © 2010 Mosby, Inc. All rights reserved.)
- Published
- 2010
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