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Markers of bone remodeling in neoplastic and bone-related lesions.
- Source :
-
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics [Oral Surg Oral Med Oral Pathol Oral Radiol Endod] 2010 Nov; Vol. 110 (5), pp. 624-31. - Publication Year :
- 2010
-
Abstract
- Objective: The aim of this study was to investigate the expression of bone resorption (RANK/RANKL), bone resorption inhibitor (osteoprotererin [OPG]), and bone formation marker (osteocalcin [OC]) in neoplastic and bone-related lesions (BRL).<br />Study Design: Using immunohistochemistry, their expression was evaluated in ossifying fibroma (OF), fibrous dysplasia (FD), simple bone cysts (SBC), central giant cell lesions (CGCL), and osteosarcoma (OS).<br />Results: Quantitative analyses of the expression of bone markers between all lesions, considering fibroblast-like cells and bone matrix, showed that RANK-RANKL presented higher expression in OF and CGCL, whereas OPG and OC presented higher expression in FD and SBC. There was higher expression of all proteins investigated when OS was the BRL. Moreover, the RANKL expression was greater than OPG in this neoplasm.<br />Conclusion: Our data indicate that the bone resorption markers are more highly expressed in OF, CGCL, and OS than in FD and SBC, indicating a significant association between these proteins and the clinical behavior of these lesions.<br /> (Copyright © 2010 Mosby, Inc. All rights reserved.)
- Subjects :
- Adolescent
Adult
Biomarkers analysis
Biomarkers, Tumor analysis
Bone Matrix pathology
Bone Resorption physiopathology
Child
Female
Fibroblasts pathology
Fibroma, Ossifying pathology
Fibrous Dysplasia of Bone pathology
Giant Cells pathology
Granuloma, Giant Cell pathology
Humans
Jaw Cysts pathology
Male
Middle Aged
Osteoblasts pathology
Osteoclasts pathology
Osteogenesis physiology
Osteosarcoma pathology
Stromal Cells pathology
Young Adult
Bone Remodeling physiology
Jaw Diseases pathology
Jaw Neoplasms pathology
Osteocalcin analysis
Osteoprotegerin analysis
RANK Ligand analysis
Receptor Activator of Nuclear Factor-kappa B analysis
Subjects
Details
- Language :
- English
- ISSN :
- 1528-395X
- Volume :
- 110
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
- Publication Type :
- Academic Journal
- Accession number :
- 20955951
- Full Text :
- https://doi.org/10.1016/j.tripleo.2010.06.014