1. [Extensive mesenteric ischemia related to naratriptan overuse associated with grapefruit juice absorption].
- Author
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Gergaud S, Lermite E, Butel F, Soltner C, and Lasocki S
- Subjects
- Abdominal Pain etiology, Colectomy, Electrocardiography, Female, Humans, Intestines surgery, Ischemia surgery, Middle Aged, Multiple Organ Failure complications, Shock drug therapy, Shock etiology, Citrus paradisi, Food-Drug Interactions, Ischemia chemically induced, Piperidines adverse effects, Serotonin Agents adverse effects, Splanchnic Circulation physiology, Tryptamines adverse effects
- Abstract
We reported the case of a 61-year-old woman, who has been hospitalized in ICU because of an extensive mesenteric ischaemia, involving the small bowel, secondary to a naratriptan overuse. This mesenteric ischaemia was complicated by multiple organ failure and was responsible for extensive small bowel resection and left colectomy. A concomitant abundant absorption of grapefruit juice, a well-known P450 inhibitor, may have enhanced this naratriptan toxicity. This case underscore that an abdominal pain occurring in the context of headache treatment may be related to a mesenteric ischaemia., (Copyright © 2012 Société française d’anesthésie et de réanimation (Sfar). Published by Elsevier SAS. All rights reserved.)
- Published
- 2012
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