1. Potential radioprotective agents. 1. Homologs of melatonin.
- Author
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Blickenstaff RT, Brandstadter SM, Reddy S, and Witt R
- Subjects
- 5-Methoxytryptamine chemical synthesis, Acylation, Amides chemical synthesis, Animals, Injections, Intraperitoneal, Male, Melatonin chemical synthesis, Mice, Photons, Structure-Activity Relationship, 5-Methoxytryptamine analogs & derivatives, 5-Methoxytryptamine pharmacology, Melatonin analogs & derivatives, Melatonin pharmacology, Radiation-Protective Agents chemical synthesis, Radiation-Protective Agents pharmacology
- Abstract
Homologs of melatonin were prepared by acylation of 5-methoxytryptamine with the appropriate acid chloride or anhydride. The products were administered as solutions or suspensions in soybean oil by ip injection to mice 30 min prior to irradiation with 950 cGy of 6 mV photons. Protection was achieved with all compounds, survival rate being maximal for mice treated with the hexanoic amide 5 and the octanoic amide 6.
- Published
- 1994
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