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Total synthesis of 1,11- and 3,11-diazasteroids.
- Source :
-
Journal of pharmaceutical sciences [J Pharm Sci] 1978 Feb; Vol. 67 (2), pp. 283-4. - Publication Year :
- 1978
-
Abstract
- The 2- and 6-methoxy derivatives of 8-aminoquinoline, as well as 5-aminoisoquinoline, condensed with 2-ethoxycarbonylcyclopentanone to give tricyclic intermediates in 86-90% yield. These secosteroids were cyclized in 35-69% yield with polyphosphoric acid to 2-methoxy-1,11-diaza-, 7-methoxy-1,11-diaza-, and 3,11-diaza-1,3,5,7,9,13-gonahexaen-12-ones, respectively. The latter exhibits slight antileukemic activity.
Details
- Language :
- English
- ISSN :
- 0022-3549
- Volume :
- 67
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of pharmaceutical sciences
- Publication Type :
- Academic Journal
- Accession number :
- 621661
- Full Text :
- https://doi.org/10.1002/jps.2600670248