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The paper reveals the future teachers’ attitude towards freedom and responsibility in the context of sustainable development of education. Sustainable development seems to be impossible without the new generation of free, dignified, respectful, and responsible individuals. Freedom and responsibility are outlined from a pedagogical point of view. The concepts under study are considered to be of great significance for child’s development. The information obtained during the survey and questionnaire conducted with first-year students of the pedagogical university indicates that future teachers do not yet have sufficient experience to correlate adequately the possibility of revealing school students’ freedom and the need to be in charge of the behavior, actions and thoughts of their own. University students believe that school students generally take responsibility for completing individual assignments rather than common ones. Future teachers do not think that school students’ attitude towards education is responsible and trustworthy, would-be teachers doubt that school students are able to manifest freedom and responsibility to full extent. The empirical data drive to the conclusion that it is necessary to change future teachers’ attitude towards freedom and responsibility in their pedagogical activities. Future teachers are advised to change their attitude to freedom and responsibility in their activities.

Age-related changes in human cardiomyocytes are closely related to cardiac diseases, especially atrial fibrillation. Restricted availability of biological preparations from the human atrial myocardium complicates experimental studies on the aging processes in cardiomyocytes. In this preliminary study, we used available experimental data on the age-related changes in ionic conductances in canine atrial cardiomyocytes to predict possible consequences of similar remodeling in humans using two mathematical models (Courtemanche98 and Maleckar09) of human atrial cardiomyocytes. The study was performed using the model population approach, allowing one to assess variability in the cellular response to different interventions affecting model parameters. Here, this approach was used to evaluate the effects of age-related parameter modulation on action potential biomarkers in the two models. Simulation results show a significant decrease in the action potential duration and membrane potential at 20% of the action potential duration in aging. These model predictions are consistent with experimental data from mammalians. The action potential characteristics are shown to serve as notable biomarkers of age-related electrophysiological remodeling in human atrial cardiomyocytes. A comparison of the two models shows different behavior in the prediction of repolarization abnormalities.

Electrophysiology of cardiomyocytes changes with aging. Agerelated ionic remodeling in cardiomyocytes may increase the incidence and prevalence of atrial fibrillation (AF) in the elderly and affect the efficiency of antiarrhythmic drugs. There is the deep lack of experimental data on an action potential and transmembrane currents recorded in the healthy human cardiomyocytes of different age. Experimental data in mammals is also incomplete and often contradicting depending on the experimental conditions. In this in-silico study, we used a population of ionic models of human atrial cardiomyocytes to transfer data on the age- related ionic remodeling in atrial cardiomyocytes from canines and mice to predict possible consequences for human cardiomyocyte activity. Based on experimental data, we analyzes two hypotheses on the aging effect on the ionic currents using two age-related sets of varied model parameters and evaluated corresponding changes in action potential morphology with aging. Using the two populations of aging models, we analyzed the agedependent sensitivity of atrial cardiomyocytes to Dofetilide which is one of the antiarrhythmic drugs widely used in patients with atrial fibrillation.

The article discusses the possibility of the development of axiological competences in university students in the process of teaching language-related disciplines within the world educational space. The problem of the development of communicative competences is relevant in the modern educational environment; it determines the purpose of the study: to analyze the survey results illustrating the attitude of students to the value of communication in society. During the research, linguistic and axiological parameters, defined by students as linguistic and communicative values, were identified, which makes it possible to talk about modern trends in education. Particular attention is paid to the value categories of the Russian language as the basis for national and cultural orientation, successful communication, intellectual development of people and formation of their linguistic personalities. The authors regard the axiological approach in the development of the student’s communicative competences as a fundamentally structured vision of the world through the prism of value orientation, which in the practice of cognition allows developing competences based on the cognitive needs and communicative intentions of students.

In the paper the concept MONEY is considered to be one in a special class of concepts which we propose to call prothteconomic concepts, as they combine prothtologic (everyday) and academic (economic) elements. The prothtologic element of the concept reveals itself in the common national collective conscience, while the academic component manifests itself in the scientific conscience. The vocabulary used by the common national collective conscience describes the concept under study with different semantic attributes. Proverbs as parameological units fully illustrate the way the common national collective conscience expresses ideas and phenomena. The scientific conscience deals with terminological word stock. The comparison of the prothtologic components of the concept with the economic ones finds out coincidence in the plane of contents. As regards the plane of expression, it differs in a considerable number of instances. So the common national collective conscience has worked out its folk economics which has much in common with scientific economics and is stored in proverbs.