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In-silico analysis of aging mechanisms of action potential remodeling in human atrial cardiomyocites

Authors :
Nesterova Tatyana
Shmarko Dmitry
Ushenin Konstantin
Solovyova Olga
Source :
BIO Web of Conferences, Vol 22, p 01025 (2020)
Publication Year :
2020
Publisher :
EDP Sciences, 2020.

Abstract

Electrophysiology of cardiomyocytes changes with aging. Agerelated ionic remodeling in cardiomyocytes may increase the incidence and prevalence of atrial fibrillation (AF) in the elderly and affect the efficiency of antiarrhythmic drugs. There is the deep lack of experimental data on an action potential and transmembrane currents recorded in the healthy human cardiomyocytes of different age. Experimental data in mammals is also incomplete and often contradicting depending on the experimental conditions. In this in-silico study, we used a population of ionic models of human atrial cardiomyocytes to transfer data on the age- related ionic remodeling in atrial cardiomyocytes from canines and mice to predict possible consequences for human cardiomyocyte activity. Based on experimental data, we analyzes two hypotheses on the aging effect on the ionic currents using two age-related sets of varied model parameters and evaluated corresponding changes in action potential morphology with aging. Using the two populations of aging models, we analyzed the agedependent sensitivity of atrial cardiomyocytes to Dofetilide which is one of the antiarrhythmic drugs widely used in patients with atrial fibrillation.

Details

Language :
English, French
ISSN :
21174458
Volume :
22
Database :
Directory of Open Access Journals
Journal :
BIO Web of Conferences
Publication Type :
Academic Journal
Accession number :
edsdoj.6c9385ee582f48868d1196154b38ed63
Document Type :
article
Full Text :
https://doi.org/10.1051/bioconf/20202201025