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Objective:To compare the effects of gonadotropin-releasing hormone (GnRH) antagonist protocol and clomiphene citrate (CC) mild stimulation protocol on the clinical outcomes of in vitro fertilization- embryo transfer (IVF-ET) in patients with poor ovarian response (POR). Methods：The clinical data of 432 IVF/ ICSI cycles of POR patients from January 2015 to December 2017 in our department were retrospectively analyzed. According to the ovarian stimulation protocol, those cycles were divided into the GnRH antagonist group (n=248 cycles) and the CC mild stimulation group (n=184 cycles). Results ：There were no significant differences in age, basic FSH, BMI and duration of infertility between the two groups (P >0.05). Compared with the CC mild stimulation group, the GnRH antagonist group had the increased values of the Gn duration, Gn dosage, endometrium thickness, number of oocytes retrieved, number of transferable embrys, and fresh embryo transfer rate (P <0.05), and the decreased cycle cancellation rate (P< 0.05). There were no significant differences in the estradiol level on trigger day, the number of embryos transferred, the number of high-quality embryos transferred, embryo implantation rate, pregnancy rate, ongoing pregnancy rate and live birth rate between the two groups (P> 0.05). Conclusions ： GnRH antagonist protocol can increase the numbers of oocytes and transferable embrys and the rate of fresh embryo transfer, and reduce the cycle cancellation rate in POR patients receiving IVF-ET. It can be used as one of the treatment options for POR patients. [ABSTRACT FROM AUTHOR]

Objective：To compare the effects of two different ICSI insemination times on the reproductive outcomes of fresh embryo transfer (FET) in gonadotropin-releasing hormone (GnRH) antagonist cycles. Methods： 531 cycles of FET after the GnRH antagonist protocol were divided into two groups according to the interval time between OPU and ICSI, the group one (n=101) that the OPU-ICSI interval was ranged from 38～40 h and the group two (n=430) was 41～43 h. The differences of oocyte maturation rate, embryo quality and pregnancy outcomes between the two groups were analyzed retrospectively. Results：The oocyte maturation rate was significantly lower in the group one when compared with the group two (P＜0.05), and the miscarriage rate in group one was significantly higher (P＜0.05). There was no significant differences in the fertility rate, cleavage rate, available embryo rate, high -quality embryo rate, implant rate and pregnancy rate between the two groups (P＞0.05). Conclusions：Our results indicate that there are relatively consistent embryo quality and clinical pregnancy rate in the timing of ICSI ranged from 38～43 h. As for the finding that the miscarriage rate could be higher if the ICSI time was earlier than 40 h in the FET cycle of GnRH antagonist protocol, we think that more studies with large samples and the detailed grouping may be necessary. [ABSTRACT FROM AUTHOR]