拮抗剂方案与微刺激方案对卵巢低反应患者体外受精-胚胎 移植结局的比较

Objective:To compare the effects of gonadotropin-releasing hormone (GnRH) antagonist protocol and clomiphene citrate (CC) mild stimulation protocol on the clinical outcomes of in vitro fertilization- embryo transfer (IVF-ET) in patients with poor ovarian response (POR). Methods：The clinical data of 432 IVF/ ICSI cycles of POR patients from January 2015 to December 2017 in our department were retrospectively analyzed. According to the ovarian stimulation protocol, those cycles were divided into the GnRH antagonist group (n=248 cycles) and the CC mild stimulation group (n=184 cycles). Results ：There were no significant differences in age, basic FSH, BMI and duration of infertility between the two groups (P >0.05). Compared with the CC mild stimulation group, the GnRH antagonist group had the increased values of the Gn duration, Gn dosage, endometrium thickness, number of oocytes retrieved, number of transferable embrys, and fresh embryo transfer rate (P <0.05), and the decreased cycle cancellation rate (P< 0.05). There were no significant differences in the estradiol level on trigger day, the number of embryos transferred, the number of high-quality embryos transferred, embryo implantation rate, pregnancy rate, ongoing pregnancy rate and live birth rate between the two groups (P> 0.05). Conclusions ： GnRH antagonist protocol can increase the numbers of oocytes and transferable embrys and the rate of fresh embryo transfer, and reduce the cycle cancellation rate in POR patients receiving IVF-ET. It can be used as one of the treatment options for POR patients. [ABSTRACT FROM AUTHOR]