1. Synthesis, Chemical Characterisation, and DNA Binding Studies of Ferrocene-Incorporated Selenoureas
- Author
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Bhajan Lal, Inayat Ali Khan, Amin Badshah, Muhammad Tahir, and Raja Azadar Hussain
- Subjects
chemistry.chemical_compound ,Ferrocene ,Chemistry ,Physical chemistry ,General Chemistry ,Cyclic voltammetry ,Binding site ,Electrochemistry ,Spectroscopy ,Binding constant ,Macromolecule ,Adduct - Abstract
In this article we have presented the synthesis, chemical characterisation (by NMR and FTIR spectroscopy, atomic absorption spectrophotometry, elemental analysis, and single crystal X-ray diffraction), electrochemistry, and DNA binding studies (with cyclic voltammetry, viscometry, and UV-vis spectroscopy) of six new ferrocene incorporated selenoureas. All the six compounds interact electrostatically with DNA which was evident by a negative shift in the cyclic voltammetry peak potential of the drug–DNA adduct relative to the free drug. The drug–DNA binding constant was calculated by a decrease in peak current after the addition of DNA to the free drug. We have also reported binding site sizes and diffusion coefficients of the synthesised compounds.
- Published
- 2013
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