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Synthesis, Chemical Characterisation, and DNA Binding Studies of Ferrocene-Incorporated Selenoureas

Authors :
Bhajan Lal
Inayat Ali Khan
Amin Badshah
Muhammad Tahir
Raja Azadar Hussain
Source :
Australian Journal of Chemistry. 66:626
Publication Year :
2013
Publisher :
CSIRO Publishing, 2013.

Abstract

In this article we have presented the synthesis, chemical characterisation (by NMR and FTIR spectroscopy, atomic absorption spectrophotometry, elemental analysis, and single crystal X-ray diffraction), electrochemistry, and DNA binding studies (with cyclic voltammetry, viscometry, and UV-vis spectroscopy) of six new ferrocene incorporated selenoureas. All the six compounds interact electrostatically with DNA which was evident by a negative shift in the cyclic voltammetry peak potential of the drug–DNA adduct relative to the free drug. The drug–DNA binding constant was calculated by a decrease in peak current after the addition of DNA to the free drug. We have also reported binding site sizes and diffusion coefficients of the synthesised compounds.

Details

ISSN :
00049425
Volume :
66
Database :
OpenAIRE
Journal :
Australian Journal of Chemistry
Accession number :
edsair.doi...........782dd230e12c4963bc320869808af9fe
Full Text :
https://doi.org/10.1071/ch12570