1. Recovery of antibacterial sensitivity of ESBLs-producing fowl E. coli by sulbactam and EDTA
- Author
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Chen YuXia, Chen YanJie, Hu GongZheng, Xu LiNa, Liu JianHua, Wu Hua, Liu BaoGuang, and Meng ChunPing
- Subjects
Florfenicol ,Cefotaxime ,medicine.drug_class ,Chemistry ,Cephalosporin ,Sulbactam ,biochemical phenomena, metabolism, and nutrition ,Fosfomycin ,bacterial infections and mycoses ,Antimicrobial ,Microbiology ,chemistry.chemical_compound ,Amikacin ,polycyclic compounds ,medicine ,Ceftiofur ,medicine.drug - Abstract
To determine effect of sulbactam and EDTA on antibacterial activity of antimicrobial drugs in vitro,MIC of 10 antimicrobial agents alone and their respective combinations with sulbactam,EDTA and sulbactam+ EDTA against ESBLs-producing E.coli,were determined by using broth microdilution method.The results showed that sulbactam and EDTA can enhance antibacterial activity of parts of antimicrobial agents,the resistant rate of ESBIs-producing isolates to third generation cephalosporin ceftiofur,cefotaxime was higher than 80% and the resistant rates to fluoroquinolones,doxycycline,florfenicol,amikacin and fosfomycin were up to 100%.All the ESBIs-producing isolates were sensitive to cefepime.The resistant rate to third generation cephalosporin cefotaxime,florfenicol,amikacin and fosfomycin combinations with sulbactam,were lower than that to antibacterial drugs alone,is 0,88.9%,88.9%,0 respectively.The resistant rate to gatifloxacin,doxycycline,florfenicol,amikacin and fosfomycin combinations with EDTA,were lower than that to antibacterial drugs alone,is 30%,11.1%,22.2%,11.1%,0 respectively.The resistant rates of most strains to sulbactom+EDTA amikacin,fosfomycin,florfenicol and ceftiofur combinations were much lower than those combinations either only sulbactam or EDTA and were all 0.
- Published
- 2010