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Recovery of antibacterial sensitivity of ESBLs-producing fowl E. coli by sulbactam and EDTA
- Source :
- JOURNAL OF HUNAN AGRICULTURAL UNIVERSITY. 36:326-329
- Publication Year :
- 2010
- Publisher :
- China Science Publishing & Media Ltd., 2010.
-
Abstract
- To determine effect of sulbactam and EDTA on antibacterial activity of antimicrobial drugs in vitro,MIC of 10 antimicrobial agents alone and their respective combinations with sulbactam,EDTA and sulbactam+ EDTA against ESBLs-producing E.coli,were determined by using broth microdilution method.The results showed that sulbactam and EDTA can enhance antibacterial activity of parts of antimicrobial agents,the resistant rate of ESBIs-producing isolates to third generation cephalosporin ceftiofur,cefotaxime was higher than 80% and the resistant rates to fluoroquinolones,doxycycline,florfenicol,amikacin and fosfomycin were up to 100%.All the ESBIs-producing isolates were sensitive to cefepime.The resistant rate to third generation cephalosporin cefotaxime,florfenicol,amikacin and fosfomycin combinations with sulbactam,were lower than that to antibacterial drugs alone,is 0,88.9%,88.9%,0 respectively.The resistant rate to gatifloxacin,doxycycline,florfenicol,amikacin and fosfomycin combinations with EDTA,were lower than that to antibacterial drugs alone,is 30%,11.1%,22.2%,11.1%,0 respectively.The resistant rates of most strains to sulbactom+EDTA amikacin,fosfomycin,florfenicol and ceftiofur combinations were much lower than those combinations either only sulbactam or EDTA and were all 0.
Details
- ISSN :
- 10071032
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- JOURNAL OF HUNAN AGRICULTURAL UNIVERSITY
- Accession number :
- edsair.doi...........9bb0bdae09c44a3091f794cadf99bf0d