1. Human Placenta Is a Potent Hematopoietic Niche Containing Hematopoietic Stem and Progenitor Cells throughout Development.
- Author
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Robin, Catherine, Bollerot, Karine, Mendes, Sandra, Haak, Esther, Crisan, Mihaela, Cerisoli, Francesco, Lauw, Ivoune, Kaimakis, Polynikis, Jorna, Ruud, Vermeulen, Mark, Kayser, Manfred, van der Linden, Reinier, Imanirad, Parisa, Verstegen, Monique, Nawaz-Yousaf, Humaira, Papazian, Natalie, Steegers, Eric, Cupedo, Tom, and Dzierzak, Elaine
- Subjects
HEMATOPOIETIC stem cells ,PLACENTA ,STEM cell transplantation ,FETAL development ,LABORATORY mice ,CLINICAL medicine research - Abstract
Hematopoietic stem cells (HSCs) are responsible for the life-long production of the blood system and are pivotal cells in hematologic transplantation therapies. During mouse and human development, the first HSCs are produced in the aorta-gonad-mesonephros region. Subsequent to this emergence, HSCs are found in other anatomical sites of the mouse conceptus. While the mouse placenta con- tains abundant HSCs at midgestation, little is known concerning whether HSCs or hematopoietic progenitors are present and supported in the human placenta during development. In this study we show, over a range of developmental times including term, that the human placenta contains hematopoietic progenitors and HSCs. Moreover, stromal cell lines generated from human placenta at several developmental time points are pericyte-like cells and support human hematopoiesis. Immunostaining of placenta sections during development localizes hematopoietic cells in close contact with pericytes/ perivascular cells. Thus, the human placenta is a potent hematopoietic niche throughout development. [ABSTRACT FROM AUTHOR]
- Published
- 2009
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