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Human Placenta Is a Potent Hematopoietic Niche Containing Hematopoietic Stem and Progenitor Cells throughout Development.
- Source :
- Cell Stem Cell; Oct2009, Vol. 5 Issue 4, p385-395, 11p
- Publication Year :
- 2009
-
Abstract
- Hematopoietic stem cells (HSCs) are responsible for the life-long production of the blood system and are pivotal cells in hematologic transplantation therapies. During mouse and human development, the first HSCs are produced in the aorta-gonad-mesonephros region. Subsequent to this emergence, HSCs are found in other anatomical sites of the mouse conceptus. While the mouse placenta con- tains abundant HSCs at midgestation, little is known concerning whether HSCs or hematopoietic progenitors are present and supported in the human placenta during development. In this study we show, over a range of developmental times including term, that the human placenta contains hematopoietic progenitors and HSCs. Moreover, stromal cell lines generated from human placenta at several developmental time points are pericyte-like cells and support human hematopoiesis. Immunostaining of placenta sections during development localizes hematopoietic cells in close contact with pericytes/ perivascular cells. Thus, the human placenta is a potent hematopoietic niche throughout development. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 19345909
- Volume :
- 5
- Issue :
- 4
- Database :
- Supplemental Index
- Journal :
- Cell Stem Cell
- Publication Type :
- Academic Journal
- Accession number :
- 45002839
- Full Text :
- https://doi.org/10.1016/j.stem.2009.08.020