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Introduction: The time required to obtain Institutional Review Board (IRB) approval is a frequent subject of efforts to reduce unnecessary delays in initiating clinical trials. This study was conducted by and for IRB directors to better understand factors affecting approval times as a first step in developing a quality improvement framework., Methods: 807 IRB-approved clinical trials from 5 University of California campuses were analyzed to identify operational and clinical trial characteristics influencing IRB approval times., Results: High workloads, low staff ratios, limited training, and the number and types of ancillary reviews resulted in longer approval times. Biosafety reviews and the need for billing coverage analysis were ancillary reviews that contributed to the longest delays. Federally funded and multisite clinical trials had shorter approval times. Variability in between individual committees at each institution reviewing phase 3 multisite clinical trials also contributed to delays for some protocols. Accreditation was not associated with shorter approval times., Conclusions: Reducing unnecessary delays in obtaining IRB approval will require a quality improvement framework that considers operational and study characteristics as well as the larger institutional regulatory environment.

Schizophrenics who completed suicide were compared with those who made suicide attempts, on the basis of blind ratings of previous hospital records and follow-up interviews with treating clinicians. Results indicated that the two groups were relatively distinct. Suicides tended to live alone and to feel depressed, hopeless, worthless, and suicidal. Attempters, on the other hand, lived with their families or others and were less likely to manifest several features of depression during a period in hospital. In evaluating suicide potential among schizophrenics, living situation and mental state changes indicating depression, suicidal intent, worthlessness, and hopelessness are more important than a history of suicidal behaviour. [ABSTRACT FROM AUTHOR]

Parasites are key components of the biosphere not only due to their huge diversity, but also because they exert important influences on ecological processes. Nevertheless, we lack an understanding of the biogeographical patterns of parasite diversity. Here, we tap into the potential of biodiversity collections for understanding parasite biogeography. We assess species richness of supracommunities of helminth parasites infecting mammal assemblages in the Nearctic, and describe its relation to latitude, climate, host diversity, and land area. We compiled data from parasitology collections and assessed parasite diversity in Nearctic ecoregions for the entire parasite supracommunity of mammals in each ecoregion, as well as separately from carnivores and rodents to explore the effect of host taxonomic resolution on observed patterns. For carnivores, we found evidence of a negative latitudinal gradient, while parasites of rodents displayed no clear pattern. We found that parasite diversity was positively correlated with mean annual temperature and negatively correlated with seasonal precipitation. Parasite richness shows a diversity peak at intermediate host richness values and in carnivores correlates with temperature and seasonal precipitation. Rodent parasite diversity did not correlate with explored factors. Other researchers are encouraged to use parasitology collections to continue exploring patterns of parasite biogeography and macroecology. [ABSTRACT FROM AUTHOR]

Emerging research has outlined the possibility for virtual reality (VR) experiences, which situate users into the perspective of someone living with dementia, to enhance dementia awareness. Currently, there is limited VR research that engages care home practitioners. It is imperative this population has high levels of dementia education given their requirements to provide care and support to residents, many of whom will be living with the condition. This paper reports on an exploratory qualitative study designed to elicit the experiences of care home practitioners who engaged with the VR application: 'A walk through dementia'. Twenty practitioners, across four care homes in the United Kingdom, watched the VR scenarios and provided their views on the experience and the potential for the VR tool to be developed into a wider training programme to support dementia awareness. Data were collected via focus group discussions. Following an inductive thematic analysis, we constructed three themes. These suggested participants perceived the VR application offered them a convincing and immersive experience that was insightful and evocative , and provided 'next-level' dementia-awareness training that enabled them to reflect on care practices. Although the findings highlight important challenges for practitioners and developers wishing to use VR within dementia care, they suggest this application may be an engaging experiential learning tool that can provide care home staff with deeper cognitive and emotional awareness of living with dementia. Further work, drawing on these preliminary insights, is required to ensure the VR tool can be incorporated into a training programme that can positively contribute to the 'dementia-friendly communities' agenda. [ABSTRACT FROM AUTHOR]

The North American model of wildlife conservation, based on the public trust doctrine, is credited for the recovery of several charismatic wildlife species, including the plains bison Bison bison. In that model, wildlife is a public resource from which the private sector may not profit either individually or collectively. In recent years, however, resilience thinking is driving changes in the traditional state-run wildlife management model to allow for integrated multi-sector approaches at the landscape scale. A free-ranging herd of bison on public land in the Henry Mountains of Utah is used as a case study to consider if and how a community-based conservation programme could be developed for a state-managed wildlife resource to benefit all stakeholders. The Henry Mountains bison, which are disease-free, share the rangeland with cattle that are privately owned by individual ranchers and corporations with various economic goals and environmental values. The ranchers currently derive no benefits from the bison and have concerns regarding competition between bison and cattle. However, a threshold harvesting strategy with community participation could generate revenue to offset these concerns. It could also provide benefits to the local community, increase state revenue, and increase the size of the bison population while securing its long-term genetic viability. Implementation would initially require facilitation by policy specialists, after which we suggest a Henry Mountains bison partnership could serve as a model for bison recovery efforts elsewhere in North America. [ABSTRACT FROM AUTHOR]

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The topic of proton-boron fusion has recently attracted considerable interest in the scientific community, both for its future perspectives for energy production and for nearer-term possibilities to realize high-brightness α -particle sources. Very interesting experimental results have been obtained, in particular in laser-driven experiments but also using other experimental approaches. The goal of this special issue is to collect the most recent developments in experiments, theory, advanced targetry, diagnostics, and numerical simulation codes. [ABSTRACT FROM AUTHOR]

As there is currently no cure for dementia, providing psycho-social support is imperative. Counselling and psychotherapeutic interventions offer a way to provide individualised support for people with dementia and their families. However, to date, there has not been a systematic review examining the research evidence for these interventions. This review aimed to examine the following research questions: (1) Are counselling/psychotherapeutic interventions effective for people with dementia?, (2) Are counselling/psychotherapeutic interventions effective for care-givers of people with dementia? and (3) Which modes of delivery are most effective for people with dementia and care-givers of people with dementia? A systematic literature search was conducted in MEDLINE (via PubMed), PsycINFO and CINAHL in March 2019. Keyword searches were employed with the terms 'dement*', 'counsel*', 'psychotherapy', 'therap*', 'care' and 'outcome', for the years 2000–2019. Thirty-one papers were included in the review, from seven countries. Twenty studies were randomised controlled trials (RCTs) or adopted a quasi-experimental design. The remaining studies were qualitative or single-group repeated-measures design. The review identified variation in the counselling/psychotherapeutic approaches and mode of delivery. Most interventions adopted either a problem-solving or cognitive behavioural therapy approach. Mixed effectiveness was found on various outcomes. The importance of customised modifications for people with dementia was highlighted consistently. Understanding the dyadic relationships between people with dementia and their care-givers is essential to offering effective interventions and guidance for practitioners is needed. Information about the cognitive impairment experienced by participants with dementia was poorly reported and is essential in the development of this research area. Future studies should consider the impact of cognitive impairment in developing guidance for counselling/psychotherapeutic intervention delivery for people with dementia. [ABSTRACT FROM AUTHOR]

Background: There is a paucity of simulation-based dementia education programmes for acute care settings that support the development of interpersonal skills pertinent to good care. Moreover, few studies measure the effectiveness of such programmes by evaluating the persistence of practice change beyond the immediate timeframe of the workshops. We were commissioned by Health Education England (HEE) to develop and evaluate 'DEALTS 2', a national simulation-based education toolkit informed by the Humanisation Values Framework, developed at Bournemouth University and based on an experiential learning approach to facilitate positive impacts on practice. This paper describes the process of developing DEALTS 2 and the protocol for evaluating the impact of this intervention on practice across England.Methods: Intervention development: Following an initial scoping exercise to explore the barriers and enablers of delivering the original DEALTS programme, we developed, piloted, and rolled out DEALTS 2 across England through a Train the Trainer (TTT) model. Key stakeholders were asked to critically feedback during the development process.Evaluation Design: Mixed methods approach underpinned by Kirkpatrick Model for evaluating effectiveness of training; assessing reaction, learning, behaviour, and results. Evaluation forms and telephone interviews (quantitative and qualitative) with trainers that attended TTT workshops (n = 196) and, once implemented in individual Trusts, the staff that the trainers train.Conclusions: Evaluation of implementation and impact on care delivery for people with dementia will provide evidence of effectiveness. This will support the future development of simulation-based education programmes, amidst the current complexity of pressure in resource limited healthcare settings. [ABSTRACT FROM AUTHOR]

Investigating how different forms of inequality arose and were sustained through time is key to understanding the emergence of complex social systems. Due to its long-term perspective, archaeology has much to contribute to this discussion. However, comparing inequality in different societies through time, especially in prehistory, is difficult because comparable metrics of value are not available. Here we use a recently developed technique which assumes a correlation between household size and household wealth to investigate inequality in the ancient Near East. If this assumption is correct, our results show that inequality increased from the Neolithic to the Iron Age, and we link this increase to changing forms of social and political organization. We see a step change in levels of inequality around the time of the emergence of urban sites at the beginning of the Bronze Age. However, urban and rural sites were similarly unequal, suggesting that outside the elite, the inhabitants of each encompassed a similar range of wealth levels. The situation changes during the Iron Age, when inequality in urban environments increases and rural sites become more equal. [ABSTRACT FROM AUTHOR]

Paolo Emilio Botta, who was sent to Mosul as the French Consul in 1842, explored at Kuyunjik and Nebi Yunus and then began investigating ancient stone foundations at Nebi Yunus. Muhammed/Mehmed Pasha and local religious leaders, who were worried that the tomb of prophet Yunus (Jonah) and a local mosque would be destroyed by the excavations, opposed these investigations and the work stopped as a result. After Nebi Yunus, Botta started to work at Kuyunjik in December 1842. While his workers were busy at Kuyunjik, someone from the village of Khorsabad talked about stones with inscriptions and reliefs on them on top of a hill. After three months of exhaustive work at Kuyunjik, on March 20th, 1843 Botta sent a group of workers to Khorsabad for excavation. However, problems arose about Botta's work in Mosul. The Pasha of the province in particular created obstructions. We have done research in the Ottoman Archives of the Prime Ministry of Turkey on Botta's excavation permits and documents, the obstructions created by the Pasha of Mosul, the details of the story of Botta's experiences at Khorsabad and the relevant correspondence. In these archives we have found documents about the problems Botta experienced at Khorsabad, the conditions for excavation permits and the construction of an excavation house, the plan of the excavation house mentioned by Botta, which was drafted like a fortress next to the village houses and sent to Istanbul, as well as petitions of the villagers opposing Botta's work and his excavation house. Here, we attempt to re-read Botta's excavation seasons, permits and the problems he encountered through the documents in the Ottoman Archives in order to understand how this period is to be understood. Through these documents and correspondence, we were able to study the problems that arose between the Ottoman State and France as a result of Botta's excavations at Khorsabad. [ABSTRACT FROM AUTHOR]

The development and subsistence strategies adopted in ancient settlements are crucial to the understanding of long-term human–environmental interaction in the past. Here, we reassess the chronology of the ancient walled settlement of Sanjiao in the Hexi Corridor in northwestern China through accelerator mass spectrometry radiocarbon (AMS 14C) dating and explore the subsistence of the settlers inside through the identification of carbonized seeds and charcoal. In addition, high-resolution paleoclimate records in the Hexi Corridor and nearby regions are employed to explore the reason for the construction of Sanjiao. Our results show that Sanjiao was built around 828 cal BC and remained inhabited through 384–116 cal BC. This indicates Sanjiao is the earliest known walled settlement in the Hexi Corridor. Ancient people at Sanjiao consumed crops such as barley, broomcorn millet, and foxtail millet, and used wood from Tamarix chinensis , Tamarix , Salix , Picea , Hippophae , Betulacea e, and Poaceae as fuel. The construction date of Sanjiao correlates with climate deterioration and social upheavals in the Hexi Corridor, potentially suggesting a defensive purpose for the site. [ABSTRACT FROM AUTHOR]

Aims.: Suicide-related behaviours are common in schizophrenia and are significantly associated with premature death. The objective of this meta-analysis study was to estimate the pooled prevalence of suicide-related behaviours in schizophrenia patients in China. Methods.: The relevant literature was searched systematically via the relevant electronic databases (PubMed, Embase, PsycINFO, Chinese National Knowledge Infrastructure, Wanfang Databases and Chinese Biological Medical Literature Database) from their inception until 14 September 2016. Only original studies that reported the prevalence of suicide-related behaviours including suicidal ideation (SI), suicide plan, suicide attempt (SA) and completed suicide were selected. Results.: Nineteen articles met the inclusion criteria and were analysed. The pooled lifetime prevalence of SI and SA were 25.8% (95% CI 14.7–41.1%) and 14.6% (95% CI 9.1–22.8%), respectively. The 1-month prevalence of SI was 22.0% (95% CI 18.2–26.4%). Subgroup analyses of lifetime SI and SA showed that gender, sample size, survey year, study location and source of patients have no significant mediating effects on the results. Conclusions.: Suicide-related behaviours are common in Chinese schizophrenia patients. Due to the high mortality risk, regular screening and effective suicide prevention programmes are warranted. [ABSTRACT FROM AUTHOR]

Background: In response to increasing numbers of older people in general hospitals who have cognitive impairment such as dementia and delirium, many hospitals have developed education and training programmes to prepare staff for this area of clinical practice.AimsTo review the evidence on educational interventions on hospital care for older people with cognitive impairment.Method: A mixed methods systematic review and narrative synthesis was undertaken. The following electronic databases were searched: Medline, Embase, CINAHL, PsycINFO, EBM Reviews, ASSIA and Scopus, as well as Health Management Information Consortium (HMIC), ProQuest, PubMed and SCIE: Social Care Online. Initial searches were run in August 2014 (update search September 2016). Titles and abstracts of studies retrieved were screened independently. The full text of eligible studies were then independently assessed by two review team members. All included studies were assessed using a standard quality appraisal tool.Results: Eight studies relating to delirium, six on dementia and two on delirium and dementia were included, each testing the use of a different educational intervention. Overall, the quality of the studies was low. In relation to delirium, all studies reported a significant increase in participants' knowledge immediately post-intervention. Two of the dementia studies reported an increase in dementia knowledge and dementia confidence immediately post-intervention.Conclusions: The variety of outcomes measured makes it difficult to summarise the findings. Although studies found increases in staff knowledge, there is insufficient evidence to conclude that educational interventions for staff lead to improved patient outcomes.Declaration of interestNone. [ABSTRACT FROM AUTHOR]

Mannheimia haemolytica is the major cause of severe pneumonia in bovine respiratory disease (BRD). Early M. haemolytica bacterins were either ineffective or even enhanced disease in vaccinated cattle, which led to studies of the bacterium's virulence factors and potential immunogens to determine ways to improve vaccines. Studies have focused on the capsule, lipopolysaccharide, various adhesins, extracellular enzymes, outer membrane proteins, and leukotoxin (LKT) resulting in a strong database for understanding immune responses to the bacterium and production of more efficacious vaccines. The importance of immunity to LKT and to surface antigens in stimulating immunity led to studies of individual native or recombinant antigens, bacterial extracts, live-attenuated or mutant organisms, culture supernatants, combined bacterin-toxoids, outer membrane vesicles, and bacterial ghosts. Efficacy of several of these potential vaccines can be shown following experimental M. haemolytica challenge; however, efficacy in field trials is harder to determine due to the complexity of factors and etiologic agents involved in naturally occurring BRD. Studies of potential vaccines have led current commercial vaccines, which are composed primarily of culture supernatant, bacterin-toxoid, or live mutant bacteria. Several of those can be augmented experimentally by addition of recombinant LKT or outer membrane proteins. [ABSTRACT FROM AUTHOR]

This paper aims to advance the scientific understanding of the role of culture, particularly cultural orientation, in development and psychopathology. We advance a theoretical framework that conceptualizes cultural orientation as a developmental construct represented by multiple psychological dimensions and social identities, and influenced by the contexts in which individuals are embedded. This perspective suggests that cultural orientation changes within individuals over time as a function of their experiences with and memberships in multiple groups, including the mainstream and ethnic culture groups, as well as a function of their normative developmental changes (i.e., the development of cognitive, social, and emotional capabilities). In addition, this framework places the development of an ethnic culture social identity (e.g., an ethnic identity) and a mainstream culture social identity in broader developmental perspectives that recognize these as two of the many social identities that are simultaneously embedded within the individual's self-concept and that simultaneously influence one's cultural orientation. To support the successful integration of culture into the study of development and psychopathology, we describe how highly reliable and valid measures of cultural orientation, indexed by individuals' social identities, are essential for generating a scientifically credible understanding of the role of cultural orientation in development and psychopathology. Further, we detail some best research practices associated with our developmental and contextual framework, and note some important considerations for researchers interested in studying cultural orientation, development, and psychopathology. [ABSTRACT FROM AUTHOR]

Anthrax is an important disease caused by the bacterium Bacillus anthracis affecting both domestic and wild animals at the wildlife/livestock interface, defined here as a physical space in which wild and domestic species overlap in range and potentially interact. In endemic regions, sporadic anthrax outbreaks occur, causing significant deaths of both wildlife and livestock and sporadically, humans. However, it may also occur as isolated outbreaks with a few animals affected. Such isolated anthrax outbreaks maybe missed. High seroprevalence among carnivores suggests either regular non-fatal exposure to the pathogen circulating in a given environment, or contact with missed cases through consumption of anthrax carcases. To investigate the relevance of this potential indicator, a cross-sectional study was conducted to determine anthrax seroprevalence in domestic dogs (Canis lupus familiaris) from selected interface and non-interface areas of Zimbabwe with known history of anthrax outbreaks. Based on past anthrax outbreaks in the respective areas, the sites were further classified as high or low risk areas for anthrax outbreaks. Sera were collected from domestic dogs (n = 186) and tested for antibodies against B. anthracis protective antigens (PA) using an ELISA test. The overall seroprevalence was 51.6% (96/186; 95% CI 44.2-59.0). Sites from the non-interface areas recorded a significantly (P < 0.001) higher (72.1%) anthrax seroprevalence compared with those from the wildlife -livestock interface (41.5%). The results demonstrated a strong association (χ2 = 14.3; OR = 3.2, 1.6 < OR < 6.2, P < 0.001) between anthrax seropositivity and interface type. Low-risk sites (42.5%) had a significantly (P = 0.044) lower seroprevalence compared with high-risk sites (58.5%) but still demonstrated high seroprevalence for areas where anthrax was last reported more than 20 years back. Dogs from Tsholotsho South were more than 90-times (OR = 96.5, 13.5 < OR < 690.8) more likely to be seropositive compared with those from Hwange. The study demonstrated the potential to use domestic dogs as indicators of anthrax in the study areas to survey anthrax circulation in supposed low-risk areas and calls for a redefinition of both low and high risk areas for anthrax in Zimbabwe based on an improved surveillance. [ABSTRACT FROM AUTHOR]

Background: A range of endophenotypes characterise psychosis, however there has been limited work understanding if and how they are inter-related. Methods: This multi-centre study includes 8754 participants: 2212 people with a psychotic disorder, 1487 unaffected relatives of probands, and 5055 healthy controls. We investigated cognition [digit span (N = 3127), block design (N = 5491), and the Rey Auditory Verbal Learning Test (N = 3543)], electrophysiology [P300 amplitude and latency (N = 1102)], and neuroanatomy [lateral ventricular volume (N = 1721)]. We used linear regression to assess the interrelationships between endophenotypes. Results: The P300 amplitude and latency were not associated (regression coef. −0.06, 95% CI −0.12 to 0.01, p = 0.060), and P300 amplitude was positively associated with block design (coef. 0.19, 95% CI 0.10–0.28, p < 0.001). There was no evidence of associations between lateral ventricular volume and the other measures (all p > 0.38). All the cognitive endophenotypes were associated with each other in the expected directions (all p < 0.001). Lastly, the relationships between pairs of endophenotypes were consistent in all three participant groups, differing for some of the cognitive pairings only in the strengths of the relationships. Conclusions: The P300 amplitude and latency are independent endophenotypes; the former indexing spatial visualisation and working memory, and the latter is hypothesised to index basic processing speed. Individuals with psychotic illnesses, their unaffected relatives, and healthy controls all show similar patterns of associations between endophenotypes, endorsing the theory of a continuum of psychosis liability across the population. [ABSTRACT FROM AUTHOR]

The Biological Survey of Canada initiated a project in 1979 to collect and synthesise information on the native arthropod fauna of the vanishing grassland habitats of Canada. At that time, it was thought that the Canadian arthropod fauna might comprise about 66 000 species. Recent studies suggest that the fauna may exceed 100 000 species, of which >25% may occur in the Prairies Ecozone. Results of this near 40-year project have been published in four volumes of the Arthropods of Canadian Grasslands monograph series of the Biological Survey of Canada. Here, the editors of this series review the grasslands project of the Biological Survey of Canada, summarise the contents of the volumes, and discuss current knowledge on the diversity of the grasslands arthropods of Canada. Whereas information on the species richness of some groups in the Prairies Ecozone is largely complete, information on the diversity of many other groups remains sparse. Reviewing the steps between initiation and publication of the Arthropods of Canadian Grasslands series may aid development of similar projects elsewhere. Identifying knowledge gaps will direct future research efforts. Identifying the diversity of grassland arthropods, their distribution and abundance, and the ecosystem services that they provide will facilitate efforts to conserve the remaining grassland habitats in Canada. [ABSTRACT FROM AUTHOR]

One enduring priority for ecologists has been to understand the cause(s) of variation in reproductive effort among species and localities. Avian clutch size generally increases with increasing latitude, both within and across species, but the mechanism(s) driving that pattern continue to generate hypotheses and debate. In 1961, a Ph.D. student at Oxford University, N. Philip Ashmole, proposed the influential hypothesis that clutch size varies in direct proportion to the seasonality of resources available to a population. Ashmole's hypothesis has been widely cited and discussed in the ecological literature. However, misinterpretation and confusion has been common regarding the mechanism that underlies Ashmole's hypothesis and the testable predictions it generates. We review the development of well-known hypotheses to explain clutch size variation with an emphasis on Ashmole's hypothesis. We then discuss and clarify sources of confusion about Ashmole's hypothesis in the literature, summarise existing evidence in support and refutation of the hypothesis, and suggest some under-utilised and novel approaches to test Ashmole's hypothesis and gain an improved understanding of the mechanisms responsible for variation in avian clutch size and fecundity, and life-history evolution in general., (© 2021 Cambridge Philosophical Society.)

Bone possesses a remarkable repair capacity to regenerate completely without scar tissue formation. This unique characteristic, expressed during bone development, maintenance and injury (fracture) healing, is performed by the reparative cells including skeletal stem cells (SSCs) and their descendants. However, the identity and functional roles of SSCs remain controversial due to technological difficulties and the heterogeneity and plasticity of SSCs. Moreover, for many years, there has been a biased view that bone marrow is the main cell source for bone repair. Together, these limitations have greatly hampered our understanding of these important cell populations and their potential applications in the treatment of fractures and skeletal diseases. Here, we reanalyse and summarize current understanding of the reparative cells in bone regeneration and repair and outline recent progress in this area, with a particular emphasis on the temporal and spatial process of fracture healing, the sources of reparative cells, an updated definition of SSCs, and markers of skeletal stem/progenitor cells contributing to the repair of craniofacial and long bones, as well as the debate between SSCs and pericytes. Finally, we also discuss the existing problems, emerging novel technologies and future research directions in this field., (© 2020 Cambridge Philosophical Society.)

Human-driven species annihilations loom as a major crisis. However the recovery of deer and wolf populations in many parts of the northern hemisphere has resulted in conflicts and controversies rather than in relief. Both species interact in complex ways with their environment, each other, and humans. We review these interactions in the context of the ecological and human costs and benefits associated with these species. We integrate scattered information to widen our perspective on the nature and perception of these costs and benefits and how they link to each other and ongoing controversies regarding how we manage deer and wolf populations. After revisiting the ecological roles deer and wolves play in contemporary ecosystems, we explore how they interact, directly and indirectly, with human groups including farmers, foresters, shepherds, and hunters. Interactions with deer and wolves generate various axes of tension, posing both ecological and sociological challenges. Resolving these tensions and conflicts requires that we address key questions using integrative approaches: what are the ecological consequences of deer and wolf recovery? How do they influence each other? What are the social and socio-ecological consequences of large deer populations and wolf presence? Finally, what key obstacles must be overcome to allow deer, wolves and people to coexist? Reviewing contemporary ecological and sociological results suggests insights and ways to improve our understanding and resolve long-standing challenges to coexistence. We should begin by agreeing to enhance aggregate benefits while minimizing the collective costs we incur by interacting with deer and wolves. We should also view these species, and ourselves, as parts of integrated ecosystems subject to long-term dynamics. If co-existence is our goal, we need deer and wolves to persevere in ways that are compatible with human interests. Our human interests, however, should be inclusive and fairly value all the costs and benefits deer and wolves entail including their intrinsic value. Shifts in human attitudes and cultural learning that are already occurring will reshape our ecological interactions with deer and wolves., (© 2020 Cambridge Philosophical Society.)

I would like to thank the commenters for spending their time on critical and constructive responses to my paper ‘Performing towns’. The comments add valuable insights, knowledge, viewpoints and ideas, which significantly elucidate the possibilities as well as the limitations of approaching medieval urban communities from a social-practice theoretical perspective (SPT). The commenters have pointed at theoretical questions too superficially treated, the need for a more extensive knowledge base and, most importantly, the need for a broader discussion of the methodological and empirical consequences of an SPT approach in analysing everyday life in a Scandinavian urban community based on archaeological empirical data. Rather than giving individual feedback, I instead centre my reply around four topics that the commenters have raised and which relate closely to the paper's paramount issue and development potential. [ABSTRACT FROM PUBLISHER]

In his illuminating article, Christophersen rethinks concepts in and approaches to the archaeological study of urban living, focusing especially on medieval urban towns in Scandinavia. He recruits various concepts – interaction, event, leakage and creativity – from a materially imbued social-practice theory to explore the urban landscapes as a complex of dynamic social spaces. Christophersen draws from scholars (Hodder 2012; Reckwitz 2002; Schatzki 1996; Shove, Pantzar and Watson 2012) who emphasize that practice is routinized behaviour through which actions and events are performed, that practices are tied to a place and timescape, that social actors live with and interact with materials, and that materials may be the media of interaction with others. Following Hodder (2012), he emphasizes that the nature and quality of social and material relationships lead to the formation and stabilization of practices. In turn, this practice constitutes the town or city. [ABSTRACT FROM PUBLISHER]

In this paper, Axel Christophersen does three important things. First, he addresses the way in which the inhabitants of premodern cities created an urban ethos through their cumulative daily actions. Second, he provides the opportunity to address a long-standing definitional challenge in the study of cities by examining what it means to undergo a process of ‘urbanization’. Finally, he focuses our attention on medieval Scandinavia as a region that has had a considerable amount of archaeological research but with which many readers may not be familiar compared to other historical periods in Europe. [ABSTRACT FROM PUBLISHER]

The contribution by Axel Christophersen aims to present new perspectives for the archaeology of medieval and post-medieval towns. In enlisting ‘social-practice theory’, the author would like to view the town as a dynamic, ever-changing network of social and cultural practices which is registered in the archaeological data. This perspective on the town lies, therefore, somewhere between structure-centred and agent-centred approaches. As such, Axel Christophersen's contribution can be seen as more comprehensive. I assess the piece also as a programmatic contribution to the development of theory in the apparently long-term conflict between ‘processual and postprocessual archaeology’. It should be said in advance that he was successful in this. At the same time, however, his contribution makes it clear that it is not easy to transfer or apply current cultural-studies concepts to historical periods and the materiality of archaeological data. [ABSTRACT FROM PUBLISHER]

Any reader expecting yet another contribution on the urbanization of Scandinavia will be misguided reading Axel Christophersen's contribution on ‘performing towns’. As the author makes very clear, he focuses on urbanity in the sense of urban social practice rather than on urbanization itself. The latter concept is straightforwardly dismissed as belonging to processual archaeology, and was trying to understand the town as a being structure and neglecting the dynamic role of its individual inhabitants as a ‘crucial historical driving force’ (p. 110). Christophersen also omits the classic discussion – actually besides Christianization one of the two most prominent topics in early medieval archaeology – on the designation and character of the earliest towns in the north, where early towns are merely defined as population centres ‘larger than a village and smaller than a city’ (p. 112). Instead, with the adoption of practice theory, Christophersen picks one heuristic approach from modern social theory (mentalism (subjectivistic/objectivistic), intersubjectivism, textualism and practice theory itself) for the analysis of social phenomena as routinized body/knowledge/things complexes (Reckwitz 2002, 257–58). [ABSTRACT FROM PUBLISHER]

I welcome Axel Christophersen's effort to offer a new approach to the study of Scandinavian medieval urban communities, and his outline of an ‘urban archaeology of social practice’. His presentation of a theoretical framework and language offers many insights as to how archaeologists can analyse the way people constructed their social lives through practice. It is exciting to see studies that grapple with the complexities of everyday life in urban settings. This article makes a significant contribution in its explicit approach to a theory of practice that archaeologists can use to explore and describe social change. Christophersen draws heavily on the work of Shove, Pantzar and Watson as detailed in their 2012 book The dynamics of social practice. Everyday life and how it changes; I was unfamiliar with this work until reading this essay and I am impressed with the way this framework offers a language and a concrete approach to understanding how practices emerge, evolve and disappear. My goal here is not to revisit the details of this argument, but rather to push on some select issues raised in the paper. I first discuss the way that Christophersen frames his arguments against a processual archaeological approach, suggesting that his effort to provide an alternative might be unintentionally minimizing a more critical approach to everyday life. Next, I discuss the role and place of unintended consequences in Christophersen's argument. And finally I examine the way that Christophersen's approach might be more fully operationalized with data, providing some examples from my own work in eastern Africa. [ABSTRACT FROM PUBLISHER]

Urban archaeology in Scandinavia has long been dominated by a processual understanding of medieval urban development. The author proposes that the concept of urbanity in the sense of ‘urban living’ should replace the processual and functionalist-oriented concept of ‘urbanization’, and that instead focus should be directed towards social processes, practices and materiality. He perceives the emergence of urbanity in the Middle Ages in the light of the formation of specific urban patterns of practice that can be analysed with the aid of theoretical tools from recent social-practice theory. Against this background, the potential of recent social-practice theory is examined as a possible analytical tool in an urban archaeological approach to medieval urban communities. Through concepts such as interaction, event, leakage and creativity, the medieval urban landscape can be reformulated as a dynamic social space in which diverse everyday routines were intertwined in patterns, bundles and complexes. [ABSTRACT FROM PUBLISHER]

Epidemiological rate parameters of host generalist parasites are difficult to estimate, especially in cases where variation in parasite performance can be attributed to host species. Such cases are likely common for generalist parasites of sympatric grazing mammals. In this study, we combined data from experimental exposures in cattle and sheep and natural infections in elk to compare the recruitment, morphology and reproduction of adult Dicrocoelium dendriticum, a generalist trematode that has emerged in sympatric grazing hosts in Cypress Hills Provincial Park, Alberta. Overall, there were no significant differences in the recruitment of metacercariae and in the pre-patency period of adults in experimentally exposed cattle and sheep. All flukes reached reproductive maturity and the degree of reproductive inequality between individual flukes within each infrapopulation was moderate and approximately equal among the three host species. Neither fluke size nor per capita fecundity was constrained by density dependence. Thus, fitness parameters associated with growth and reproduction were approximately equivalent among at least three species of definitive host, two of which are sympatric on pastures in this Park. The generalist life-history strategy of this trematode, which is known to extend to other stages of its life cycle, has likely contributed to its invasion history outside its native range in Europe. [ABSTRACT FROM PUBLISHER]

Shared values, public trust in an agency, and attitudes can influence support for successful conservation initiatives. To understand these relationships, this paper examines the role of social trust as a partial mediator between salient values similarity and attitudes toward wolves in south-western Alberta, Canada. Rural residents in this area face increasing wolf depredation on livestock. Data were obtained from a mail questionnaire (n = 566 respondents, response rate = 70%) sent to rural residents in three municipal districts in south-western Alberta. Attitudes were predicted to directly influence behavioural intention to support or oppose wolf management. Most respondents held slightly similar values as the management agency and minimally trusted the agency to effectively manage wolves. As predicted, social trust in the agency served as a partial mediator between salient value similarity and attitudes toward wolves. Salient value similarity was also a strong predictor of attitudes toward wolves. Attitudes toward wolves predicted behavioural support. Thus, social trust of the management agency can influence attitudes and management preferences concerning a species. When dealing with human-wildlife conflict, social trust should be examined to understand the context of the problem. [ABSTRACT FROM PUBLISHER]

For a closed, oriented, odd dimensional manifold X, we define the rho invariant ρ(X,${\cal E}$,H) for the twisted odd signature operator valued in a flat hermitian vector bundle ${\cal E}$, where H = ∑ ij+1H2j+1 is an odd-degree closed differential form on X and H2j+1 is a real-valued differential form of degree 2j+1. We show that ρ(X,${\cal E}$,H) is independent of the choice of metrics on X and ${\cal E}$ and of the representative H in the cohomology class [H]. We establish some basic functorial properties of the twisted rho invariant. We express the twisted eta invariant in terms of spectral flow and the usual eta invariant. In particular, we get a simple expression for it on closed oriented 3-dimensional manifolds with a degree three flux form. A core technique used is our analogue of the Atiyah–Patodi–Singer theorem, which we establish for the twisted signature operator on a compact, oriented manifold with boundary. The homotopy invariance of the rho invariant ρ(X,${\cal E}$,H) is more delicate to establish, and is settled under further hypotheses on the fundamental group of X. [ABSTRACT FROM PUBLISHER]

We study a class of Hermitian metrics on complex manifolds, recently introduced by Fu, Wang and Wu, which are a generalization of Gauduchon metrics. This class includes the class of Hermitian metrics for which the associated fundamental 2-form is ∂∂-closed. Examples are given on nilmanifolds, on products of Sasakian manifolds, on S1-bundles and via the twist construction introduced by Swann. [ABSTRACT FROM PUBLISHER]

In this article the authors discuss how data gaps in images of ice motion can be filled with random data. The authors tested their method using photographs of the Pine Island Ice Shelf in Antarctica. They observed an increase in the velocity field for glacier's floating extension. It highlights that though the method was applied to Landsat7 images, it can be applied to other images also.

We investigate the computing power of a restricted class of DNA strand displacement structures: those that are made of double strands with nicks (interruptions) in the top strand. To preserve this structural invariant, we impose restrictions on the single strands they interact with: we consider only two-domain single strands consisting of one toehold domain and one recognition domain. We study fork and join signal processing gates based on these structures, and show that these systems are amenable to formalisation and mechanical verification. [ABSTRACT FROM AUTHOR]

Background: Individuals experiencing psychosis can present with elevated levels of depression and anxiety. Research suggests that aspects of depression and anxiety may serve an avoidant function by limiting the processing of more distressing material. Acceptance and Commitment Therapy suggests that avoidance of aversive mental experiences contributes to psychological inflexibility. Depression and anxiety occurring in the context of psychosis have a limiting effect on quality of life. No research to date has investigated how levels of psychological flexibility and mindfulness are associated with depression and anxiety occurring following psychosis. Aims: This study investigated associations psychological flexibility and mindfulness had with depression and anxiety following psychosis. Method: Thirty participants with psychosis were recruited by consecutive referral on the basis that they were experiencing emotional dysfunction following psychosis. The Hospital Anxiety and Depression Scale (HADS), Positive and Negative Syndrome Scale (PANSS), Acceptance and Action Questionnaire (AAQ-II) and the Kentucky Inventory of Mindfulness Skills (KIMS) were used. A cross-sectional correlational design was used. Results: The depression and anxiety subscales of the HADS both had significant correlations with psychological flexibility (as assessed by the AAQ-II) and aspects of mindfulness (as assessed by the KIMS). Hierarchical regression analyses indicated that psychological flexibility, but not mindfulness, contributed significantly to models predicting 46% of variance in both depression and anxiety scores. Conclusions: Although aspects of mindfulness are associated with depression and anxiety following an episode of psychosis, psychological flexibility appears to account for a larger proportion of variance in depression and anxiety scores in this population. [ABSTRACT FROM AUTHOR]

A bibliography is presented on the topic of urban history which includes the article "Rat Cities and Beehive Worlds: Density and Design in the Modern City," by J. Adams and E. Ramsden, published in the journal "Comparative Studies in Society and History," the book "A Prospering Society: Wiltshire in the Later Middle Ages," by J. Hare, and the article "Tottenham Court Road: The Changing Fortunes of London’s Furniture Street 1850-1950," by C. Edwards, published in the periodical "London Journal."

We prove that any invariant strong Kähler structure with torsion (SKT structure) on a flag manifold M = G/K of a semi-simple compact Lie group G is Kähler. As an application we describe invariant generalized Kähler structures on M. [ABSTRACT FROM PUBLISHER]

Migratory pathways in North American prairies are critical for sustaining endemic biodiversity. Fragmentation and loss of habitat by an encroaching human footprint has extirpated and severely truncated formerly large movements by prairie wildlife populations. Greater sage-grouse Centrocercus urophasianus, a Near Threatened landscape species requiring vast tracts of intact sagebrush Artemisia spp., exhibit varied migratory strategies across their range in response to the spatial composition of available habitats. We unexpectedly documented the longest migratory event ever observed in sage-grouse (> 120 km one way) in 2007–2009 while studying demography of a population at the north-east edge of their range. Movements that encompassed 6,687 km2 included individuals using distinct spring and summer ranges and then freely intermixing on the winter range in what is probably an obligate, annual event. The fate of greater sage-grouse in Canada is in part dependent on habitat conservation in the USA because this population spans an international border. Expanding agricultural tillage and development of oil and gas fields threaten to sever connectivity for this imperilled population. Science can help delineate high priority conservation areas but the fate of landscapes ultimately depends on international partnerships implementing conservation at scales relevant to prairie wildlife. [ABSTRACT FROM PUBLISHER]

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BackgroundRecent genetic studies found the A allele of the variant rs1006737 in the alpha 1C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene to be over-represented in patients with psychosis, including schizophrenia, bipolar disorder and major depressive disorder. In these disorders, attention deficits are among the main cognitive symptoms and have been related to altered neural activity in cerebral attention networks. The particular effect of CACNA1C on neural function, such as attention networks, remains to be elucidated.MethodThe current event-related functional magnetic resonance imaging (fMRI) study investigated the effect of the CACNA1C gene on brain activity in 80 subjects while performing a scanner-adapted version of the Attention Network Test (ANT). Three domains of attention were probed simultaneously: alerting, orienting and executive control of attention.ResultsRisk allele carriers showed impaired performance in alerting and orienting in addition to reduced neural activity in the right inferior parietal lobule [Brodmann area (BA) 40] during orienting and in the medial frontal gyrus (BA 8) during executive control of attention. These areas belong to networks that have been related to impaired orienting and executive control mechanisms in neuropsychiatric disorders.ConclusionsOur results suggest that CACNA1C plays a role in the development of specific attention deficits in psychiatric disorders by modulation of neural attention networks. [ABSTRACT FROM PUBLISHER]

Molecular approaches are being used increasingly for epidemiological studies of visceral and cutaneous leishmaniases. Several molecular markers resolving genetic differences between Leishmania parasites at species and strain levels have been developed to address key epidemiological and population genetic questions. The current gold standard, multilocus enzyme typing (MLEE), needs cultured parasites and lacks discriminatory power. PCR assays identifying species directly with clinical samples have proven useful in numerous field studies. Multilocus sequence typing (MLST) is potentially the most powerful phylogenetic approach and will, most probably, replace MLEE in the future. Multilocus microsatellite typing (MLMT) is able to discriminate below the zymodeme level and seems to be the best candidate for becoming the gold standard for distinction of strains. Population genetic studies by MLMT revealed geographical and hierarchic population structure in L. tropica, L. major and the L. donovani complex. The existence of hybrids and gene flow between Leishmania populations suggests that sexual recombination is more frequent than previously thought. However, typing and analytical tools need to be further improved. Accessible databases should be created and sustained for integrating data obtained by different researchers. This would allow for global analyses and help to avoid biases in analyses due to small sample sizes. [ABSTRACT FROM PUBLISHER]

Background: The Self-Regulation Model (SRM) has been presented as a framework for assessing the perceptions people hold about their mental health problem. Currently no direct attempts have been made to assess the association between illness perceptions and engagement in psychosis. Engagement is an important issue for health professionals providing support to people with psychosis; therefore, research demonstrating a link between illness perceptions and engagement may enable targeted interventions to facilitate engagement and enhance outcome. Aim: To assess whether beliefs about mental health are associated with self-perceptions of engagement in people with psychosis. Method: Participants with psychosis completed two questionnaires; beliefs about mental health and self-perceptions of engagement with mental health services. Results: A belief that the mental health difficulty has fewer negative consequences, increased perceptions of personal ability to control the mental health difficulty, a belief that treatment is helpful in controlling symptoms and a more coherent understanding of the mental health difficulty were all associated with higher self-perception engagement scores. Multivariate analyses indicated that a more coherent understanding and a belief that treatment is helpful were the strongest and most consistent predictors of higher self-perception engagement scores. However, the direction of the associations cannot be established. Conclusions: This study suggests that the SRM is a promising model for mental health problems and that beliefs about mental health are associated with self-perceptions of engagement in people with psychosis. The importance of further intervention-based research studies that examines causality is highlighted. [ABSTRACT FROM AUTHOR]