1. Ocular hypotensive effect of the novel EP3/FP agonist ONO-9054 versus Xalatan: results of a 28-day, double-masked, randomised study
- Author
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Caroline L Ward, Eydie Miller Ellis, John Sharpe, Michael S. Berlin, Alam Jamil, and Alon Harris
- Subjects
Male ,Intraocular pressure ,Time Factors ,genetic structures ,Ocular hypertension ,Glaucoma ,chemistry.chemical_compound ,0302 clinical medicine ,Latanoprost ,Aged, 80 and over ,Clinical Science ,Middle Aged ,Clinical Trial ,Sensory Systems ,Treatment Outcome ,Anesthesia ,Prostaglandins F, Synthetic ,Female ,Glaucoma, Open-Angle ,Adult ,Agonist ,Prostaglandin E receptor 3 ,Adolescent ,medicine.drug_class ,Young Adult ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,Double-Blind Method ,Post-hoc analysis ,medicine ,Humans ,In patient ,Aged ,Retrospective Studies ,Dose-Response Relationship, Drug ,business.industry ,medicine.disease ,eye diseases ,Ophthalmology ,chemistry ,Oxepins ,030221 ophthalmology & optometry ,Ocular Hypertension ,sense organs ,Ophthalmic Solutions ,business ,030217 neurology & neurosurgery ,Follow-Up Studies - Abstract
Background/aims ONO-9054 is being developed for the reduction of intraocular pressure (IOP) in patients with ocular hypertension (OHT) and open-angle glaucoma (OAG). This study compared the novel dual EP3/FP agonist ONO-9054 with the FP agonist Xalatan. Methods Adults (n=123) with bilateral mild/moderate OAG or OHT, with unmedicated IOP of ≥24 mm Hg at 8:00 hours, ≥21 mm Hg at 10:00 hours and ≤36 mm Hg, were randomised 1:1 to receive ONO-9054 (0.003%, 30 μg/mL) or Xalatan (0.005%, 50 μg/mL) once daily for 28 days. Results Day 29 mean diurnal IOP was −7.2 mm Hg for ONO-9054 vs −6.6 mm Hg for Xalatan. At 08:00 hours, the IOPs were comparable, and at all later time points the decrease in IOP was greater for ONO-9054. On day 29, the odds of a mean IOP reduction of ≤−25%, ≤−30% and ≤−35% for ONO-9054 were 2.39, 2.37 and 4.85 times more, respectively, than the odds for Xalatan (p
- Published
- 2016
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