Back to Search
Start Over
Ocular hypotensive effect of the novel EP3/FP agonist ONO-9054 versus Xalatan: results of a 28-day, double-masked, randomised study
- Source :
- The British Journal of Ophthalmology
- Publication Year :
- 2016
- Publisher :
- BMJ, 2016.
-
Abstract
- Background/aims ONO-9054 is being developed for the reduction of intraocular pressure (IOP) in patients with ocular hypertension (OHT) and open-angle glaucoma (OAG). This study compared the novel dual EP3/FP agonist ONO-9054 with the FP agonist Xalatan. Methods Adults (n=123) with bilateral mild/moderate OAG or OHT, with unmedicated IOP of ≥24 mm Hg at 8:00 hours, ≥21 mm Hg at 10:00 hours and ≤36 mm Hg, were randomised 1:1 to receive ONO-9054 (0.003%, 30 μg/mL) or Xalatan (0.005%, 50 μg/mL) once daily for 28 days. Results Day 29 mean diurnal IOP was −7.2 mm Hg for ONO-9054 vs −6.6 mm Hg for Xalatan. At 08:00 hours, the IOPs were comparable, and at all later time points the decrease in IOP was greater for ONO-9054. On day 29, the odds of a mean IOP reduction of ≤−25%, ≤−30% and ≤−35% for ONO-9054 were 2.39, 2.37 and 4.85 times more, respectively, than the odds for Xalatan (p
- Subjects :
- Male
Intraocular pressure
Time Factors
genetic structures
Ocular hypertension
Glaucoma
chemistry.chemical_compound
0302 clinical medicine
Latanoprost
Aged, 80 and over
Clinical Science
Middle Aged
Clinical Trial
Sensory Systems
Treatment Outcome
Anesthesia
Prostaglandins F, Synthetic
Female
Glaucoma, Open-Angle
Adult
Agonist
Prostaglandin E receptor 3
Adolescent
medicine.drug_class
Young Adult
03 medical and health sciences
Cellular and Molecular Neuroscience
Double-Blind Method
Post-hoc analysis
medicine
Humans
In patient
Aged
Retrospective Studies
Dose-Response Relationship, Drug
business.industry
medicine.disease
eye diseases
Ophthalmology
chemistry
Oxepins
030221 ophthalmology & optometry
Ocular Hypertension
sense organs
Ophthalmic Solutions
business
030217 neurology & neurosurgery
Follow-Up Studies
Subjects
Details
- ISSN :
- 14682079 and 00071161
- Volume :
- 101
- Database :
- OpenAIRE
- Journal :
- British Journal of Ophthalmology
- Accession number :
- edsair.doi.dedup.....9c992a738dfafddc9f8767bd3775fb56
- Full Text :
- https://doi.org/10.1136/bjophthalmol-2016-309023