12 results on '"Photosensitivity Disorders immunology"'
Search Results
2. Solar urticaria confined to areas of bruising.
- Author
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Esdaile B, Grabczynska S, and George S
- Subjects
- Adult, Humans, Male, Photosensitivity Disorders immunology, Urticaria immunology, Photosensitivity Disorders etiology, Sunlight adverse effects, Urticaria etiology
- Abstract
Solar urticaria is a rare immunoglobulin E-mediated photodermatosis characterized by the development of a pathognomic wheal and flare within minutes of photoexposure. A 26-year-old man presented with a history of sun-induced urticaria only in areas of pre-existing bruising, which we were able to replicate with monochromator testing. We were also able to demonstrate, by autologous in vitro studies, that a serum factor was responsible.
- Published
- 2010
- Full Text
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3. Systemic photosensitivity due to a contraceptive patch.
- Author
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Gómez-Bernal S, Loureiro M, Rodríguez-Granados MT, and Toribio J
- Subjects
- Administration, Cutaneous, Adult, Contraceptive Agents administration & dosage, Female, Humans, Photosensitivity Disorders immunology, Contraceptive Agents adverse effects, Photosensitivity Disorders etiology
- Abstract
Hormonal contraceptives are a known but rarely reported cause of photosensitivity. A 35-year-old female developed several episodes of a prurigionous papulovesicular eruption located on sun-exposed areas that resolved without scarring in days. She had been using a transdermal contraceptive (EVRA: norelgestromin and ethinyloestradiol) for 3 years, and once it was stopped, the patient became asymptomatic. She had another episode after the use of oral contraceptives (YAZ: ethinyloestradiol and drospirenone). The biopsy of the lesions showed a spongiotic dermatitis. Minimal erythema dose was diminished when the patient was using EVRA and YAZ and became normal when they were withdrawn. Phototesting with UVA, photopatch testing and blood porphyrins were normal. Antinuclear antibodies were 1/80 initially and were 1/320 6 months later. Anti-deoxyribonucleic acid antibodies, extractable nuclear antigens, anti Ro and Anti La were negative and no systemic symptoms had developed. When all hormonal contraceptives were stopped, the patient became asymptomatic. We report a case of systemic photosensitivity induced by the contraceptive patch. To the best of our knowledge, no other cases induced by transdermal contraceptives have been reported previously.
- Published
- 2010
- Full Text
- View/download PDF
4. A Korean experience with chronic actinic dermatitis during an 18-year period: meteorological and photoimmunological aspects.
- Author
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Kyu-Won C, Chae-Young L, Yeong-Kyu L, Young-Hun K, and Ki-Ho K
- Subjects
- Adult, Aged, Chronic Disease, Female, Humans, Immunoglobulin E blood, Male, Middle Aged, Photosensitivity Disorders immunology, Photosensitivity Disorders physiopathology, Republic of Korea epidemiology, Light, Meteorology, Photosensitivity Disorders epidemiology
- Abstract
Background and Purpose: The authors noted that chronic actinic dermatitis (CAD) increased in connection with increased sun exposure and believed that there may be a correlation between the two. The purpose of this study was to determine the relationship between increased sun exposure and CAD. We also applied a clinical severity scoring system to determine the correlation with various laboratory parameters., Materials and Methods: We investigated trends in sun exposure in Pusan during an 18-year period. We conducted photopatch/patch testing in 51 CAD patients. We also determined the total IgE, percentage of eosinophils, and chemokine receptor profiles in the peripheral blood and analyzed correlations between laboratory data and the clinical severity of CAD., Results: A close correlation was demonstrated between the number of CAD patients and increased sun exposure. Positive patch test reactions and positive photopatch reactions were observed in 35 and 41 of the 51 tested patients, respectively. The total IgE levels were higher in the severe group than in the others. CCR4 expression increased in parallel with clinical severity., Conclusion: Korean patients may have increased susceptibility to CAD with increased sun exposure. We believe that the majority of the CAD patients tested had photoallergy and contact allergy. The clinical severity seemed to correlate well with the total IgE level and CCR4 expression.
- Published
- 2009
- Full Text
- View/download PDF
5. Polymorphous light eruption.
- Author
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Hönigsmann H
- Subjects
- Child, Dermatologic Agents therapeutic use, Female, Humans, Male, Phototherapy, Risk Factors, Skin Tests, Photosensitivity Disorders diagnosis, Photosensitivity Disorders etiology, Photosensitivity Disorders immunology, Photosensitivity Disorders therapy, Skin pathology, Ultraviolet Rays adverse effects
- Abstract
Polymorphous light eruption is the most common photodermatosis, with a prevalence of as high as 10-20% in Western Europe and in the USA. It starts during the second and third decades of life. Although not life-threatening it can severely impair the quality of life, in particular during leisure activities and in outdoors workers. Polymorphous light eruption belongs to the group of so-called idiopathic photodermatoses. This term denotes dermatoses that occur in otherwise healthy individuals from exposure to sunlight or artificial light without the intervention of an exogenous photosensitizing agent. These diseases have two factors in common: they are precipitated by ultraviolet or visible radiation; and their exact pathomechanism remains obscure but is presumably immunologic in nature.
- Published
- 2008
- Full Text
- View/download PDF
6. Association of HLA subtype DRB10407 in Colombian patients with actinic prurigo.
- Author
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Suárez A, Valbuena MC, Rey M, and de Porras Quintana L
- Subjects
- Adolescent, Adult, Child, Colombia, Female, Humans, Male, Middle Aged, Polymerase Chain Reaction, Polymorphism, Single-Stranded Conformational, HLA-DR Antigens immunology, Photosensitivity Disorders immunology, Prurigo immunology
- Abstract
Background: Human leukocyte antigen (HLA) DRB1*0407 had been associated with actinic prurigo in different populations. This class II HLA-DR subtype had not been studied in Colombia., Objective: The objective of this study was to establish whether there was an association of actinic prurigo with HLA DR in a Colombian population., Materials and Methods: Forty patients with a clinical diagnosis of actinic prurigo and 40 healthy subjects, paired by age, sex and birthplace, were studied. HLA typing for HLA DRB1 and DRB1*04, if necessary, was performed by the PCR-SSP method using blood samples., Results: A high frequency of HLA DRB1*0407 was found in the patients (97.5% vs. 30%; P<0.00001). The allelic frequency of HLA DRB1*0407 was 63.8% in the case group, and 14.5% in the controls (P<0.00001). In the control group, there was a higher frequency of the alleles DRB1*01 (14.5% vs. 1.25%; P=0.0027) and DRB1*13 (23.7% vs. 2.5%; P=0.00013)., Limitations: The small number of controls does not allow us to drive conclusions about other HLA alleles., Conclusions: HLA subtype DRB1*0407, found in actinic prurigo patients in studies conducted in England, Scotland, Ireland and Mexico, was also associated in Colombian patients. This finding, concordant in patients from different ethnic groups, could be helpful in the diagnosis of this disease and probably important in its pathogenesis. DRB1*01 and DRB1*13 alleles were more frequent in controls than in patients; we do not know whether they play any role in the resistance to the disease.
- Published
- 2006
- Full Text
- View/download PDF
7. Photosensitivity in lupus erythematosus.
- Author
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Scheinfeld N and Deleo VA
- Subjects
- Apoptosis, Autoantibodies immunology, Humans, Lupus Erythematosus, Cutaneous complications, Lupus Erythematosus, Cutaneous immunology, Lupus Erythematosus, Systemic immunology, Photosensitivity Disorders immunology, Tumor Necrosis Factor-alpha immunology, Ultraviolet Rays, Lupus Erythematosus, Systemic complications, Photosensitivity Disorders etiology
- Abstract
Background: Lupus erythematosus is a systemic disease process that may manifest with a variety of internal and cutaneous findings. Photosensitivity is one the most common manifestations of lupus erythematosus. In patients with lupus erythematosus, there is a relationship between exposure to ultraviolet light, autoantibodies, genetics and other factors in the development of photosensitivity., Methods: Literature was reviewed on the topics of lupus erythematosus and photosensitivity discussed together and separately. The suggested mechanisms for their relationship were reviewed and analyzed., Results: Photosensitivity's relationship to and influence on the systemic manifestations of lupus remain to be defined. Mechanisms for photosensitivity might include: modulation of autoantibody location, cytotoxic effects, apoptosis induction with autoantigens in apoptotic blebs, upregulation of adhesion molecules and cytokines, induction of nitric oxide synthase expression and ultraviolet-generated antigenic DNA. Tumor necrosis factor alpha also seems to play a role in the development of photosensitivity., Conclusion: The basis for photosensitivity in lupus has yet to be fully defined. It is more commonly associated with subacute and tumid lupus erythematosus than with other variants. Anti-Ro antibodies appear to relate to photosensitivity. Tumor necrosis factor alpha polymorphisms appear to be important in some variants of lupus with photosensitivity. There is no sine qua non antibody or mutation of photosensitivity in lupus. In patients with lupus, more work needs to be done to define the mechanisms of photosensitivity.
- Published
- 2004
- Full Text
- View/download PDF
8. Chronic actinic dermatitis: a case report and immunohistological analysis in its early phase.
- Author
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Koga C, Aragane Y, Matsushita K, Yamazaki F, Maeda A, Kawada A, and Tezuka T
- Subjects
- Apoptosis, Chronic Disease, Humans, In Situ Nick-End Labeling, Male, Middle Aged, Photosensitivity Disorders etiology, Photosensitivity Disorders immunology, Ultraviolet Rays adverse effects
- Published
- 2002
- Full Text
- View/download PDF
9. What is actinic prurigo in Britain?
- Author
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Grabczynska SA and Hawk JL
- Subjects
- Adolescent, Adult, Age Factors, Antigen Presentation, Chronic Disease, Cicatrix pathology, Female, HLA-DR Antigens analysis, HLA-DR Antigens classification, HLA-DRB1 Chains, Humans, Male, Photosensitivity Disorders diagnosis, Photosensitivity Disorders immunology, Photosensitivity Disorders pathology, Prurigo diagnosis, Prurigo immunology, Prurigo pathology, Puberty, Seasons, Sex Factors, Skin Tests, Sunlight adverse effects, United Kingdom, Photosensitivity Disorders physiopathology, Prurigo physiopathology
- Abstract
Actinic prurigo (AP) belongs to the group of idiopathic photodermatoses sharing a predilection for occurring more commonly in females, and there is much controversy as to whether it is only a more severe form of polymorphous light eruption (PMLE) or whether it is a distinct entity in its own right. The condition is characterised by intensely itchy papules, plaques and nodules, along with excoriations and scars usually starting before puberty, and predominantly involves the sun-exposed areas although it may also affect covered sites. Seasonal exacerbations at the beginning of spring with improvement in the fall are typical, although the lesions frequently do not clear completely in the winter. The disorder may run a chronic course and persist into adulthood, but often spontaneous resolution occurs in late adolescence. Diagnosis is predominantly based on the clinical features, cutaneous irradiation tests and histology often being normal or non-specific. HLA typing has also been performed in both PMLE and AP patients, showing a strong association between HLA-DR4, in particular with the DRB1*0407 subtype, and AP; no HLA association has been found in PMLE. This HLA association is likely to be of pathogenic significance and strongly suggests a critical role for MHC-restricted antigen presentation in the development of photosensitivity AP.
- Published
- 1997
- Full Text
- View/download PDF
10. Actinic prurigo.
- Author
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Lane PR
- Subjects
- Adult, Age Factors, Canada, Colombia, Female, HLA Antigens analysis, Humans, Male, Indians, North American, Indians, South American, Photosensitivity Disorders diagnosis, Photosensitivity Disorders immunology, Photosensitivity Disorders physiopathology, Photosensitivity Disorders prevention & control, Prurigo diagnosis, Prurigo immunology, Prurigo physiopathology, Prurigo prevention & control
- Published
- 1997
- Full Text
- View/download PDF
11. Protective effect of topically applied conjugated hexadienes against ultraviolet radiation-induced chronic skin damage in the hairless mouse.
- Author
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Bissett DL, Majeti S, Fu JJ, McBride JF, and Wyder WE
- Subjects
- Animals, Chronic Disease, Dermatitis, Contact genetics, Female, Immunity genetics, Mice, Mice, Hairless, Photosensitivity Disorders genetics, Skin drug effects, Skin pathology, Skin Aging drug effects, Skin Aging radiation effects, H-2 Antigens genetics, Hexanols pharmacology, Immunity radiation effects, Photosensitivity Disorders immunology, Skin radiation effects, Ultraviolet Rays adverse effects
- Abstract
Albino hairless mice (SkH:HR-1) exposed chronically to suberythemal doses of ultraviolet B (UVB) radiation display visible skin wrinkling and tumors. Topical treatment of mice with solutions of conjugated dienes (2,4-hexadien-1-ol and derivatives of it) prior to each UVB radiation exposure reduces significantly the severity of these visible alterations. Chronic suberythemal doses of ultraviolet A radiation induce skin sagging, a distinctly different visible skin alteration. The severity of skin sagging is not reduced by topical application of the conjugated dienes tested here.
- Published
- 1990
12. Effect of the H-2 and Igh complexes on the susceptibility to ultraviolet B-induced immunosuppression in murine contact sensitivity and contact photosensitivity.
- Author
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Satoh T, Tokura Y, Takigawa M, and Yamada M
- Subjects
- Animals, Dermatitis, Contact immunology, Disease Models, Animal, Hypersensitivity, Delayed genetics, Hypersensitivity, Delayed immunology, Major Histocompatibility Complex, Male, Mice, Mice, Inbred BALB C, Photosensitivity Disorders immunology, T-Lymphocytes, Regulatory immunology, Dermatitis, Contact genetics, Genes, Immunoglobulin radiation effects, H-2 Antigens immunology, Immunoglobulin Heavy Chains immunology, Immunosuppression Therapy, Photosensitivity Disorders genetics, Ultraviolet Rays adverse effects
- Abstract
We examined the genetic control of ultraviolet B (UVB)-induced immunosuppression in contact sensitivity (CS) to DNFB, picryl chloride, and oxazolone, and contact photosensitivity (CPS) to TCSA by using various H-2- and Igh-congenic strains. The CPS responses were inhibited by UVB preirradiation in all strains tested except for A/J mice, whereas only certain strains showed the immunosuppressive effect of UVB on the CS responses. In C.B-20 (H-2d, Igh-VbCb) and C3H (H-2k, Igh-VjCj) mice, the responses to 2-3 contact agents were suppressed by UVB pre-exposure. In C.AL-20 (H-2d, Igh-VdCd) mice, the UVB-induced suppression was observed in only 1 of the 3 CS systems. In contrast, BALB/c (H-2d, Igh-VaCa), BALB.B (H-2b, Igh-VaCa), BAB-14 (H-2d, Igh-VaCb), DBA/2 (H-2d, Igh-VcCc) and A/J (H-2a, Igh-VeCe) mice did not show immunosuppression in these CS systems. These data suggested that the susceptibility to UVB in the induction of cutaneous sensitivity depended on the mouse strain. There was no significant association between the susceptibility to UVB and the H-2 haplotype. However, the Igh complex partially contributed to UVB-induced suppression, as observed in a comparison of the CS responses between the Igh congenic strains, BALB/c, BAB-14 and C.B-20.
- Published
- 1990
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