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Protective effect of topically applied conjugated hexadienes against ultraviolet radiation-induced chronic skin damage in the hairless mouse.
- Source :
-
Photodermatology, photoimmunology & photomedicine [Photodermatol Photoimmunol Photomed] 1990 Apr; Vol. 7 (2), pp. 63-7. - Publication Year :
- 1990
-
Abstract
- Albino hairless mice (SkH:HR-1) exposed chronically to suberythemal doses of ultraviolet B (UVB) radiation display visible skin wrinkling and tumors. Topical treatment of mice with solutions of conjugated dienes (2,4-hexadien-1-ol and derivatives of it) prior to each UVB radiation exposure reduces significantly the severity of these visible alterations. Chronic suberythemal doses of ultraviolet A radiation induce skin sagging, a distinctly different visible skin alteration. The severity of skin sagging is not reduced by topical application of the conjugated dienes tested here.
- Subjects :
- Animals
Chronic Disease
Dermatitis, Contact genetics
Female
Immunity genetics
Mice
Mice, Hairless
Photosensitivity Disorders genetics
Skin drug effects
Skin pathology
Skin Aging drug effects
Skin Aging radiation effects
H-2 Antigens genetics
Hexanols pharmacology
Immunity radiation effects
Photosensitivity Disorders immunology
Skin radiation effects
Ultraviolet Rays adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 0905-4383
- Volume :
- 7
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Photodermatology, photoimmunology & photomedicine
- Publication Type :
- Academic Journal
- Accession number :
- 2400676