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Your search keyword '"KOUTSILIERIS, MICHAEL"' showing total 19 results
Start Over Author "KOUTSILIERIS, MICHAEL" Publisher biomed central
19 results on '"KOUTSILIERIS, MICHAEL"'

2. Oncogenic Role of the Ec Peptide of the IGF-1Ec Isoform in Prostate Cancer

Author

Armakolas, Athanasios, Kaparelou, Maria, Dimakakos, Andreas, Papageorgiou, Efstathia, Armakolas, Nikolaos, Antonopoulos, Athanasios, Petraki, Constantina, Lekarakou, Maria, Lelovas, Pavlos, Stathaki, Martha, Psarros, Constantinos, Donta, Ismene, Galanos, Panos S., Msaouel, Paul, Gorgoulis, Vassilis G., and Koutsilieris, Michael

Published
2015
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18. The role of the insulin-like growth factor-1 system in breast cancer.

Author

Christopoulos, Panagiotis F., Msaouel, Pavlos, and Koutsilieris, Michael

Subjects
SOMATOMEDIN C, BREAST cancer, CELL proliferation, METASTASIS, CANCER invasiveness
Abstract

IGF-1 is a potent mitogen of major importance in the mammary gland. IGF-1 binding to the cognate receptor, IGF-1R, triggers a signaling cascade leading to proliferative and anti-apoptotic events. Although many of the relevant molecular pathways and intracellular cascades remain to be elucidated, a growing body of evidence points to the important role of the IGF-1 system in breast cancer development, progression and metastasis. IGF-1 is a point of convergence for major signaling pathways implicated in breast cancer growth. In this review, we provide an overview and concise update on the function and regulation of IGF-1 as well as the role it plays in breast malignancies. [ABSTRACT FROM AUTHOR]

Published
2015
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19. Diagnostic value of circulating tumor cell detection in bladder and urothelial cancer: systematic review and meta-analysis.

Author

Msaouel P and Koutsilieris M

Subjects
Carcinoma, Transitional Cell blood, Humans, Neoplasm Staging, Prognosis, Sensitivity and Specificity, Urinary Bladder Neoplasms blood, Carcinoma, Transitional Cell diagnosis, Neoplastic Cells, Circulating pathology, Urinary Bladder Neoplasms diagnosis
Abstract

Background: The diagnostic value and prognostic significance of circulating tumor cell (CTC) detection in patients with bladder cancer is controversial. We performed a meta-analysis to consolidate current evidence regarding the use of CTC detection assays to diagnose bladder and other urothelial cancers and the association of CTC positivity with advanced, remote disease., Methods: Studies that investigated the presence of CTCs in the peripheral blood of patients with bladder cancer and/or urothelial cancer were identified and reviewed. Sensitivities, specificities, and positive (LR+) and negative likelihood ratios (LR-) of CTC detection in individual studies were calculated and meta-analyzed by random effects model. Overall odds ratio of CTC positivity in patients with advanced disease versus those with organ-confined cancer was also calculated., Results: Overall sensitivity of CTC detection assays was 35.1% (95%CI, 32.4-38%); specificity, LR+, and LR- was 89.4% (95%CI, 87.2-91.3%), 3.77 (95%CI, 1.95-7.30) and 0.72 (95%CI, 0.64-0.81). CTC-positive patients were significantly more likely to have advanced (stage III-IV) disease compared with CTC-negative patients (OR, 5.05; 95%CI, 2.49-10.26)., Conclusions: CTC evaluation can confirm tumor diagnosis and identify patients with advanced bladder cancer. However, due to the low overall sensitivity, CTC detection assays should not be used as initial screening tests.

Published
2011
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