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The role of the insulin-like growth factor-1 system in breast cancer.
- Source :
- Molecular Cancer; 2015, Vol. 14 Issue 1, p1-14, 14p, 3 Diagrams
- Publication Year :
- 2015
-
Abstract
- IGF-1 is a potent mitogen of major importance in the mammary gland. IGF-1 binding to the cognate receptor, IGF-1R, triggers a signaling cascade leading to proliferative and anti-apoptotic events. Although many of the relevant molecular pathways and intracellular cascades remain to be elucidated, a growing body of evidence points to the important role of the IGF-1 system in breast cancer development, progression and metastasis. IGF-1 is a point of convergence for major signaling pathways implicated in breast cancer growth. In this review, we provide an overview and concise update on the function and regulation of IGF-1 as well as the role it plays in breast malignancies. [ABSTRACT FROM AUTHOR]
- Subjects :
- SOMATOMEDIN C
BREAST cancer
CELL proliferation
METASTASIS
CANCER invasiveness
Subjects
Details
- Language :
- English
- ISSN :
- 14764598
- Volume :
- 14
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Molecular Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 101947697
- Full Text :
- https://doi.org/10.1186/s12943-015-0291-7