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3 results on '"Coviello, V"'

1. Platelet-rich plasma improves wound healing in multiple myeloma bisphosphonate-associated osteonecrosis of the jaw patients

Author

Coviello, V, Peluso, F, Dehkhargani, S, Verdugo, F, Raffaelli, Luca, Manicone, Paolo Francesco, D'Addona, Antonio, Raffaelli, Luca (ORCID:0000-0003-4525-8446), Manicone, Paolo Francesco (ORCID:0000-0003-0283-2903), D'Addona, Antonio (ORCID:0000-0002-0876-7594), Coviello, V, Peluso, F, Dehkhargani, S, Verdugo, F, Raffaelli, Luca, Manicone, Paolo Francesco, D'Addona, Antonio, Raffaelli, Luca (ORCID:0000-0003-4525-8446), Manicone, Paolo Francesco (ORCID:0000-0003-0283-2903), and D'Addona, Antonio (ORCID:0000-0002-0876-7594)

Abstract

Bisphosphonates are drugs used to treat various metabolic and malignant bone diseases. In the past 10 years intravenous bisphosphonates have been associated with increased risk of osteonecrosis of the jaw (ONJ). The aim of the present study is to evaluate platelet-rich plasma (PRP) wound healing benefits in multiple myeloma (MM) patients who developed ONJ after surgical tooth extraction. The study included 7 patients, 2 males and 5 females. All individuals had been taking zoledronate or pamidronate followed by zoledronate for an average of 5 years. Four subjects had only standard surgical debridement and sequestrectomy to treat the ONJ and three had additional autologous PRP. The patients were followed-up for 3 months. The use of PRP to enhance wound healing and reduce bone exposure seems to be a good treatment protocol in ONJ MM subjects.

Published
2012

2. Subjective pain response to two anesthetic systems in dental surgery: traditional syringe vs. a computer controlled delivery system.

Author

Patini R, Coviello V, Raffaelli L, Manicone PF, Dehkhargani SZ, Verdugo F, Perfetti G, and D'Addona A

Subjects
Adolescent, Adult, Aged, Drug Delivery Systems, Drug Therapy, Computer-Assisted, Female, Humans, Male, Middle Aged, Single-Blind Method, Syringes, Anesthesia, Dental methods, Anesthetics administration & dosage, Pain Perception
Abstract

The present study was conducted to evaluate human pain perception at different phases of dental surgery using a computer controlled device, the Single Tooth Anesthesia System (STA System), versus the traditional syringe technique. One hundred healthy patients participated in this single-blind split-mouth design study. Individuals provided pain ratings at needle insertion, delivery of anesthetic solution and tooth extraction via a numeric visual rating scale or NVRS. The anterior middle superior alveolar, or AMSA, injection was compared with traditional syringe injections in maxillary quadrants. NVRS scores for AMSA were significantly lower for the STA System when compared to traditional syringe technique at needle insertion, delivery of anesthetic solution (p less than 0.0001) and also during tooth extractions (p=0.0002). A higher percentage of patients (23 percent) required a second injection after the traditional syringe technique. Subjects reported having less clinical pain with AMSA injection at every step of the dental surgery. The STA System combines an anesthetic pathway and controlled flow rate resulting in virtually imperceptible needle insertion and injection, and a rapid onset of profound anesthesia. NVRS scoring system facilitated patient comprehension in assessing pain value and intensity experienced. The two anesthetic delivery techniques were therapeutically equivalent for maxillary injections but AMSA/computer controlled protocol significantly minimizes subjective pain perception at needle insertion, anesthetic delivery and during tooth extraction.

Published
2012

3. Platelet-rich plasma improves wound healing in multiple myeloma bisphosphonate-associated osteonecrosis of the jaw patients.

Author

Coviello V, Peluso F, Dehkhargani SZ, Verdugo F, Raffaelli L, Manicone PF, and D' Addona A

Subjects
Aged, Aged, 80 and over, Blood Transfusion, Autologous, Diphosphonates adverse effects, Diphosphonates therapeutic use, Humans, Imidazoles adverse effects, Imidazoles therapeutic use, Pamidronate, Zoledronic Acid, Bisphosphonate-Associated Osteonecrosis of the Jaw therapy, Multiple Myeloma complications, Platelet-Rich Plasma, Tooth Extraction adverse effects, Wound Healing
Abstract

Bisphosphonates are drugs used to treat various metabolic and malignant bone diseases. In the past 10 years intravenous bisphosphonates have been associated with increased risk of osteonecrosis of the jaw (ONJ). The aim of the present study is to evaluate platelet-rich plasma (PRP) wound healing benefits in multiple myeloma (MM) patients who developed ONJ after surgical tooth extraction. The study included 7 patients, 2 males and 5 females. All individuals had been taking zoledronate or pamidronate followed by zoledronate for an average of 5 years. Four subjects had only standard surgical debridement and sequestrectomy to treat the ONJ and three had additional autologous PRP. The patients were followed-up for 3 months. The use of PRP to enhance wound healing and reduce bone exposure seems to be a good treatment protocol in ONJ MM subjects.

Published
2012

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