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Platelet-rich plasma improves wound healing in multiple myeloma bisphosphonate-associated osteonecrosis of the jaw patients.
- Source :
-
Journal of biological regulators and homeostatic agents [J Biol Regul Homeost Agents] 2012 Jan-Mar; Vol. 26 (1), pp. 151-5. - Publication Year :
- 2012
-
Abstract
- Bisphosphonates are drugs used to treat various metabolic and malignant bone diseases. In the past 10 years intravenous bisphosphonates have been associated with increased risk of osteonecrosis of the jaw (ONJ). The aim of the present study is to evaluate platelet-rich plasma (PRP) wound healing benefits in multiple myeloma (MM) patients who developed ONJ after surgical tooth extraction. The study included 7 patients, 2 males and 5 females. All individuals had been taking zoledronate or pamidronate followed by zoledronate for an average of 5 years. Four subjects had only standard surgical debridement and sequestrectomy to treat the ONJ and three had additional autologous PRP. The patients were followed-up for 3 months. The use of PRP to enhance wound healing and reduce bone exposure seems to be a good treatment protocol in ONJ MM subjects.
- Subjects :
- Aged
Aged, 80 and over
Blood Transfusion, Autologous
Diphosphonates adverse effects
Diphosphonates therapeutic use
Humans
Imidazoles adverse effects
Imidazoles therapeutic use
Pamidronate
Zoledronic Acid
Bisphosphonate-Associated Osteonecrosis of the Jaw therapy
Multiple Myeloma complications
Platelet-Rich Plasma
Tooth Extraction adverse effects
Wound Healing
Subjects
Details
- Language :
- English
- ISSN :
- 0393-974X
- Volume :
- 26
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of biological regulators and homeostatic agents
- Publication Type :
- Report
- Accession number :
- 22475108