1. Serum hepatic enzyme manifestations in patients with severe acute respiratory syndrome: Retrospective analysis
- Author
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Ping Li, Min Zhen, Zhiyuan Zhang, Bin Zhang, Hui-Juan Cui, Aiguo Li, Ying-Xu Hao, Jun Duan, Chuanjin Hua, Xiaoguang Chen, Xiao-Lin Tong, and Yuewen Gong
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,medicine.drug_class ,Antibiotics ,macromolecular substances ,Severe Acute Respiratory Syndrome ,Gastroenterology ,Antiviral Agents ,chemistry.chemical_compound ,Liver Function Tests ,Clinical Research ,Internal medicine ,Ribavirin ,medicine ,Humans ,In patient ,Aspartate Aminotransferases ,Respiratory system ,skin and connective tissue diseases ,Child ,Aged ,Retrospective Studies ,Aged, 80 and over ,biology ,medicine.diagnostic_test ,L-Lactate Dehydrogenase ,business.industry ,Incidence (epidemiology) ,Incidence ,Liver Diseases ,fungi ,Retrospective cohort study ,Alanine Transaminase ,General Medicine ,Middle Aged ,body regions ,Endocrinology ,chemistry ,Alanine transaminase ,Liver ,biology.protein ,Female ,Liver function tests ,business - Abstract
AIM: To evaluate the hepatic function in patients with severe acute respiratory syndrome (SARS) and possible causes of hepatic disorder in these patients. METHODS: One hundred and eighty-two patients with SARS were employed in a retrospective study that investigated hepatic dysfunction. Liver alanine aminotransferase (ALT), aspartate aminotransferase (AST) and lactic dehydrogenase (LDH) were analyzed in these patients. Patients with different hospital treatments were further investigated. RESULTS: Of the 182 patients, 128 (70.3%) had abnormal ALT activity, 57 (31.3%) had abnormal AST activity and 87 (47.8%) had abnormal LDH activity. The peak of elevated hepatic enzyme activities occurred between the sixth day and the tenth day after the first day of reported fever. Of the 182 patients, 160 (87.9%) had been treated with antibiotics, 137 (75.2%) with Ribavirin, and 115 (63.2%) with methylpredisolone. There was no statistically significant correlation between the duration of Ribavirin treatement and hepatic dysfunction. CONCLUSION: Abnormal liver functions were common in patients with SARS and could be associated with virus replication in the liver.
- Published
- 2004
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