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Serum hepatic enzyme manifestations in patients with severe acute respiratory syndrome: Retrospective analysis
- Source :
- World Journal of Gastroenterology
- Publication Year :
- 2004
- Publisher :
- Baishideng Publishing Group Inc., 2004.
-
Abstract
- AIM: To evaluate the hepatic function in patients with severe acute respiratory syndrome (SARS) and possible causes of hepatic disorder in these patients. METHODS: One hundred and eighty-two patients with SARS were employed in a retrospective study that investigated hepatic dysfunction. Liver alanine aminotransferase (ALT), aspartate aminotransferase (AST) and lactic dehydrogenase (LDH) were analyzed in these patients. Patients with different hospital treatments were further investigated. RESULTS: Of the 182 patients, 128 (70.3%) had abnormal ALT activity, 57 (31.3%) had abnormal AST activity and 87 (47.8%) had abnormal LDH activity. The peak of elevated hepatic enzyme activities occurred between the sixth day and the tenth day after the first day of reported fever. Of the 182 patients, 160 (87.9%) had been treated with antibiotics, 137 (75.2%) with Ribavirin, and 115 (63.2%) with methylpredisolone. There was no statistically significant correlation between the duration of Ribavirin treatement and hepatic dysfunction. CONCLUSION: Abnormal liver functions were common in patients with SARS and could be associated with virus replication in the liver.
- Subjects :
- Adult
Male
medicine.medical_specialty
Adolescent
medicine.drug_class
Antibiotics
macromolecular substances
Severe Acute Respiratory Syndrome
Gastroenterology
Antiviral Agents
chemistry.chemical_compound
Liver Function Tests
Clinical Research
Internal medicine
Ribavirin
medicine
Humans
In patient
Aspartate Aminotransferases
Respiratory system
skin and connective tissue diseases
Child
Aged
Retrospective Studies
Aged, 80 and over
biology
medicine.diagnostic_test
L-Lactate Dehydrogenase
business.industry
Incidence (epidemiology)
Incidence
Liver Diseases
fungi
Retrospective cohort study
Alanine Transaminase
General Medicine
Middle Aged
body regions
Endocrinology
chemistry
Alanine transaminase
Liver
biology.protein
Female
Liver function tests
business
Subjects
Details
- ISSN :
- 10079327
- Volume :
- 10
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- World Journal of Gastroenterology
- Accession number :
- edsair.doi.dedup.....22d005333f070f05c58456eebff78bc0
- Full Text :
- https://doi.org/10.3748/wjg.v10.i11.1652