1. Current status of diagnosis and therapy for intraductal papillary neoplasm of the bile duct.
- Author
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Sakai Y, Ohtsuka M, Sugiyama H, Mikata R, Yasui S, Ohno I, Iino Y, Kato J, Tsuyuguchi T, and Kato N
- Subjects
- Bile Ducts, Intrahepatic, Humans, Bile Duct Neoplasms diagnostic imaging, Bile Duct Neoplasms surgery, Bile Ducts, Extrahepatic, Cholangiocarcinoma diagnostic imaging, Cholangiocarcinoma therapy, Pancreatic Neoplasms diagnostic imaging, Pancreatic Neoplasms therapy
- Abstract
Bile duct epithelial tumours showing papillary neoplasm in the bile duct lumen are present in the intrahepatic and extrahepatic bile ducts. Clinicopathological images of these tumours are distinctive and diverse, including histological images with a low to high grade dysplasia, infiltrating and noninfiltrating characteristics, excessive mucus production, and similarity to intraductal papillary mucinous neoplasm (IPMN) of the pancreas. The World Health Organization Classification of Tumours of the Digestive System in 2010 named these features, intraductal papillary neoplasm of the bile duct (IPNB), as precancerous lesion of biliary carcinoma. IPNB is currently classified into type 1 that is similar to IPMN, and type 2 that is not similar to IPMN. Many of IPNB spreads superficially, and diagnosis with cholangioscopy is considered mandatory to identify accurate localization and progression. Prognosis of IPNB is said to be better than normal bile duct cancer., Competing Interests: Conflict-of-interest statement: The authors have no other disclosures., (©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.)
- Published
- 2021
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