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Beige adipocytes can dissipate energy as heat. Elaborate communication between metabolism and gene expression is important in the regulation of beige adipocytes. Although lipid droplet (LD) binding proteins play important roles in adipose tissue biology, it remains unknown whether perilipin 3 (Plin3) is involved in the regulation of beige adipocyte formation and thermogenic activities. In this study, we demonstrate that Plin3 ablation stimulates beige adipocytes and thermogenic gene expression in inguinal white adipose tissue (iWAT). Compared with wild-type mice, Plin3 knockout mice were cold tolerant and displayed enhanced basal and stimulated lipolysis in iWAT, inducing peroxisome proliferator-activated receptor α (PPARα) activation. In adipocytes, Plin3 deficiency promoted PPARα target gene and uncoupling protein 1 expression and multilocular LD formation upon cold stimulus. Moreover, fibroblast growth factor 21 expression and secretion were upregulated, which was attributable to activated PPARα in Plin3-deficient adipocytes. These data suggest that Plin3 acts as an intrinsic protective factor preventing futile beige adipocyte formation by limiting lipid metabolism and thermogenic gene expression. [ABSTRACT FROM AUTHOR] more...

A study which investigated the relationship of monocyte DPP4 expression with human aortic atherosclerosis, obesity and lipid metabolism to determine whether obesity-related increase of DPP4 has a role in vascular disease, is presented. Topics covered include positive correlation between atherosclerotic burden and monocyte DPP4 expression, increased monocyte DPP4 expression in obese atherosclerotic patients and the role of DPP4 in linking obesity and dyslipidemia with atherosclerosis. more...