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Your search keyword '"Claudia Pessoa"' showing total 3 results
Start Over Author "Claudia Pessoa" Publisher american chemical society (acs)
3 results on '"Claudia Pessoa"'

1. Seeking the Regional Identity of Brown Propolis Produced in Southern Brazil and Linked to Total Levels of Bioactive Compounds and Biological Activity

Author

Marta Chagas Monteiro, Daiane Finger, Claudia Pessoa, Thayná Modesto, Christiane Schineider Machado, Fátima de Cássia Evangelista de Oliveira, Yohandra Reyes Torres, and Thaiana Cristina Dias De Lima

Subjects
chemistry.chemical_classification, Nutraceutical, Flavonols, chemistry, Traditional medicine, Chemistry (miscellaneous), Organic Chemistry, Biological activity, Propolis, Biology, Food Science, Analytical Chemistry
Abstract

Total levels of caffeoylquinic, p-coumaric, and benzoic acid derivatives, flavonols, and dihydroflavonols were investigated in 44 brown propolis samples from the state of Parana (Brazil) together w...

Published
2021

2. Cytotoxic Diterpenoids from Croton argyrophylloides

Author

Francisco W.A. Barros, Francisco José Queiroz Monte, Claudia Pessoa, Raimundo Braz-Filho, Telma Leda Gomes de Lemos, Paulo Nogueira Bandeira, Maria Rose Jane R. Albuquerque, José Henrique Leal-Cardoso, and Hélcio Silva dos Santos

Subjects
Erythrocytes, Pharmaceutical Science, Apoptosis, HL-60 Cells, Pharmacognosy, Peripheral blood mononuclear cell, Analytical Chemistry, Mice, chemistry.chemical_compound, Drug Discovery, medicine, Animals, Humans, Cytotoxic T cell, Cytotoxicity, Pharmacology, Plants, Medicinal, Molecular Structure, biology, Hemolytic Agents, Chemistry, Organic Chemistry, biology.organism_classification, medicine.disease, Antineoplastic Agents, Phytogenic, Molecular biology, Croton, Leukemia, Complementary and alternative medicine, Biochemistry, Cell culture, Molecular Medicine, Diterpenes, Drug Screening Assays, Antitumor, Diterpene, Brazil
Abstract

Two new diterpenes, 1 and 2, together with the known ent-15-oxo-kaur-16-en-18-oic acid (3), were isolated from the bark of Croton argyrophylloides. The structural characterization of 1 and 2 was determined on the basis of spectroscopic data interpretation. The cytotoxicity of each compound was evaluated against HL-60 (leukemia), MDAMB-435 (melanoma), SF-295 (glioblastoma), and HCT-8 (colon carcinoma) human tumor cell lines and against human peripheral blood mononuclear cells. The hemolytic potential in mouse erythrocytes was also tested for 1-3.

Published
2009

3. Cytotoxic Flavonoids from Platymiscium floribundum

Author

Nilce V. Gramosa, Mary Anne S. Lima, Yvone Brígido M Pouliquem, Letícia V. Costa-Lotufo, Manoel Odorico de Moraes, Claudia Pessoa, Maria José Cajazeiras Falcão, Edilberto R Silveira, and Gardenia Carmen Gadelha Militão

Subjects
Stereochemistry, Flavonoid, Pharmaceutical Science, Pharmacognosy, Analytical Chemistry, chemistry.chemical_compound, Drug Discovery, Tumor Cells, Cultured, Humans, Medicarpin, Flavonoids, Pharmacology, chemistry.chemical_classification, Plants, Medicinal, Organic Chemistry, Quinones, Fabaceae, Biological activity, Isoflavones, Antineoplastic Agents, Phytogenic, Quinone, Complementary and alternative medicine, chemistry, Molecular Medicine, Drug Screening Assays, Antitumor, Liquiritigenin, Brazil, Isoliquiritigenin
Abstract

Two new isoflavonoids, 7-hydroxy-6,4'-dimethoxy-isoflavonequinone (1) and 2'-hydroxy-6,4',6' ',4' ''-tetramethoxy-[7-O-7' ']-bisisoflavone (2), and seven other known flavonoids, 3-hydroxy-9-methoxypterocarpan (medicarpin), 3,10-dihydroxy-9-methoxypterocarpan, 3,9-dimethoxypterocarpan (homopterocarpin) (3), 2,3,9-trimethoxypterocarpan (4), 3,4-dihydroxy-9-methoxypterocarpan (vesticarpan) (5), 2',4,4'-trihydroxychalcone (isoliquiritigenin), and 7,4'-dihydroxyflavanone (liquiritigenin) (6), were isolated from the heartwood of Platymiscium floribundum. The structures of compounds 1 and 2 were established by spectroscopic methods. Compounds 3-6 showed cytotoxic activity when evaluated against five human cancer cell lines in vitro.

Published
2005

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