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Cytotoxic Diterpenoids from Croton argyrophylloides
- Source :
- Journal of Natural Products. 72:1884-1887
- Publication Year :
- 2009
- Publisher :
- American Chemical Society (ACS), 2009.
-
Abstract
- Two new diterpenes, 1 and 2, together with the known ent-15-oxo-kaur-16-en-18-oic acid (3), were isolated from the bark of Croton argyrophylloides. The structural characterization of 1 and 2 was determined on the basis of spectroscopic data interpretation. The cytotoxicity of each compound was evaluated against HL-60 (leukemia), MDAMB-435 (melanoma), SF-295 (glioblastoma), and HCT-8 (colon carcinoma) human tumor cell lines and against human peripheral blood mononuclear cells. The hemolytic potential in mouse erythrocytes was also tested for 1-3.
- Subjects :
- Erythrocytes
Pharmaceutical Science
Apoptosis
HL-60 Cells
Pharmacognosy
Peripheral blood mononuclear cell
Analytical Chemistry
Mice
chemistry.chemical_compound
Drug Discovery
medicine
Animals
Humans
Cytotoxic T cell
Cytotoxicity
Pharmacology
Plants, Medicinal
Molecular Structure
biology
Hemolytic Agents
Chemistry
Organic Chemistry
biology.organism_classification
medicine.disease
Antineoplastic Agents, Phytogenic
Molecular biology
Croton
Leukemia
Complementary and alternative medicine
Biochemistry
Cell culture
Molecular Medicine
Diterpenes
Drug Screening Assays, Antitumor
Diterpene
Brazil
Subjects
Details
- ISSN :
- 15206025 and 01633864
- Volume :
- 72
- Database :
- OpenAIRE
- Journal :
- Journal of Natural Products
- Accession number :
- edsair.doi.dedup.....9c02277578afe0c3dd7cfa3975a92e57