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1. JBIR-23 and -24, Novel Anticancer Agents from Streptomycessp. AK-AB27.

Author

Keiichiro Motohashi, Ji-Hwan Hwang, Yoshitaka Sekido, Motoki Takagi, and Kazuo Shin-ya

Subjects
*ANTINEOPLASTIC agents, *STREPTOMYCES, *MESOTHELIOMA, *FURANS, *CHEMICAL structure, *NUCLEAR magnetic resonance, *MASS spectrometry, *THERAPEUTICS
Abstract

The screening for active compounds against malignant pleural mesothelioma (MPM) cells produced by Streptomycessp. AK-AB27 resulted in the isolation of two compounds with a dodecahydrodibenzo[b,d]furan skeleton named JBIR-23 (1) and -24 (2). Their structures were established on the basis of extensive NMR and MS analyses. Compounds 1and 2exhibited cytotoxic effects against several MPM cell lines. [ABSTRACT FROM AUTHOR]

Published
2009
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