1. Synthesis of N 2 -Substituted 1,2,3-Triazoles.
- Author
-
Kunz KA, Springer BL, Klahn P, Aldemir H, Mohr F, and Kirsch SF
- Abstract
We present a novel synthetic approach for the synthesis of the 1,2,3-triazole core, with a particular focus on the direct and regioselective synthesis of the synthetically more challenging triazoles having additional substituents at the N
2 nitrogen atom. Through treatment of readily accessible geminal diazides with organic hydrazines under mild thermolysis conditions, a broad spectrum of N2 -alkyl- and N2 -aryl-1,2,3-triazoles are easily generated. For example, geminal diazides derived from ketoesters, ketoamides, and ketones were converted under the reaction conditions. The product structures were confirmed via NMR as well as single-crystal structure analysis.- Published
- 2024
- Full Text
- View/download PDF