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Your search keyword '"Amyloidosis -- Causes of"' showing total 2 results
Start Over Descriptor "Amyloidosis -- Causes of" Publisher american chemical society
2 results on '"Amyloidosis -- Causes of"'

1. Exothermic effects observed upon heating of [beta.sub.2]-microglobulin monomers in the presence of amyloid seeds

Author

Sasahara, Kenji, Naiki, Hironobu, and Goto, Yuji

Subjects
Glycoproteins -- Risk factors, Glycoproteins -- Research, Exothermic reactions -- Analysis, Globulin -- Thermal properties, Globulin -- Research, Amyloidosis -- Causes of, Biological sciences, Chemistry
Abstract

The effects of heat on the acid-unfolded monomer at pH 2.5 were studied to understand the initial stages in the formation of amyloid fibrils of [beta.sub.2]-microglobulin ([beta]2-m), a protein responsible for dialysis-related amyloidosis. It was found that moderate heat treatment of [beta]2-m in the presence of seed fibrils results in an exothermic sigmoidal transition leading to a conformational state and may be interpreted in terms of the effects of heat associated with the formation, the association and unfolding of fibrils.

Published
2006

2. D18G transthyretin is monomeric, aggregation prone, and not detectable in plasma and cerebrospinal fluid: a prescription for central nervous system amyloidosis?

Author

Hammarstrom, Per, Sekijima, Yoshiki, White, Joleen T., Wiseman, R. Luke, Lim, Amareth, Costello, Catherine E., Altland, Klaus, Garzuly, Ferenc, Budka, Herbert, and Kelly, Jeffery W.

Subjects
Monomers -- Physiological aspects, Monomers -- Genetic aspects, Amyloidosis -- Causes of, Cell membranes -- Physiological aspects, Cell membranes -- Genetic aspects, Central nervous system -- Physiological aspects, Gene mutations -- Physiological aspects, Biophysics -- Research, Biological sciences, Chemistry
Abstract

Research has been conducted on D18G transthyretin. The authors describe the biophysical properties of this transthyretin, and report that it is an unstable monomeric protein.

Published
2003

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