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Your search keyword '"Urbani, Andrea"' showing total 2 results
Start Over Author "Urbani, Andrea" Topic serine proteinases Publisher american chemical society

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2 results on '"Urbani, Andrea"'

1. A zinc binding site in viral serine proteinases.

Author

De Francesco, Raffaele and Urbani, Andrea

Subjects
*SERINE proteinases, *HEPATITIS C virus, *ZINC
Abstract

Presents a homology model that predicts the components of the zinc binding site of the serine protease domain of NS3 protein of hepatitis C virus. Need of zinc for enzymatic activity; Properties of the metal-substituted NS3 proteinases.

Published
1996
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2. Product inhibition of the hepatitis C virus NS3 protease.

Author

Steinkuhler, Christian, Biasiol, Gabriella, Brunetti, Mirko, Urbani, Andrea, Koch, Uwe, Cortese, Riccardo, Pessi, Antonello, and De Francesco, Raffaele

Subjects
*HEPATITIS C virus, *SERINE proteinases, *CHEMICAL structure
Abstract

States that the nonstructural protein NS3 of the hepatitis C virus (HCV), harbors a serine protease domain that is responsible for most of the processing events of the nonstructural region of the polyprotein. How inhibition of NS3 affects the disease caused by HCV; Methodology used to conduct inhibition process; Identification of an important determinant for product binding; Discussion on findings.

Published
1998
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