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Product inhibition of the hepatitis C virus NS3 protease.

Authors :
Steinkuhler, Christian
Biasiol, Gabriella
Brunetti, Mirko
Urbani, Andrea
Koch, Uwe
Cortese, Riccardo
Pessi, Antonello
De Francesco, Raffaele
Source :
Biochemistry. 06/23/98, Vol. 37 Issue 25, p8899. 7p. 1 Color Photograph, 2 Charts, 5 Graphs.
Publication Year :
1998

Abstract

States that the nonstructural protein NS3 of the hepatitis C virus (HCV), harbors a serine protease domain that is responsible for most of the processing events of the nonstructural region of the polyprotein. How inhibition of NS3 affects the disease caused by HCV; Methodology used to conduct inhibition process; Identification of an important determinant for product binding; Discussion on findings.

Details

Language :
English
ISSN :
00062960
Volume :
37
Issue :
25
Database :
Academic Search Index
Journal :
Biochemistry
Publication Type :
Academic Journal
Accession number :
822161
Full Text :
https://doi.org/10.1021/bi980313v