1. Adaptive immune response of Vgamma2Vdelta2+ T cells during mycobacterial infections.
- Author
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Shen Y, Zhou D, Qiu L, Lai X, Simon M, Shen L, Kou Z, Wang Q, Jiang L, Estep J, Hunt R, Clagett M, Sehgal PK, Li Y, Zeng X, Morita CT, Brenner MB, Letvin NL, and Chen ZW
- Subjects
- Animals, Immunity, Innate immunology, Immunologic Memory immunology, Lymphocyte Activation, Lymphocyte Count, T-Lymphocytes cytology, Tuberculosis microbiology, Macaca immunology, Macaca microbiology, Mycobacterium bovis immunology, Mycobacterium tuberculosis immunology, Receptors, Antigen, T-Cell, gamma-delta immunology, T-Lymphocytes immunology, Tuberculosis immunology
- Abstract
To examine the role of T cell receptor (TCR) in gammadelta T cells in adaptive immunity, a macaque model was used to follow Vgamma2Vdelta2+ T cell responses to mycobacterial infections. These phosphoantigen-specific gammadelta T cells displayed major expansion during Mycobacterium bovis Bacille Calmette-Guérin (BCG) infection and a clear memory-type response after BCG reinfection. Primary and recall expansions of Vgamma2Vdelta2+ T cells were also seen during Mycobacterium tuberculosis infection of naive and BCG-vaccinated macaques, respectively. This capacity to rapidly expand coincided with a clearance of BCG bacteremia and immunity to fatal tuberculosis in BCG-vaccinated macaques. Thus, Vgamma2Vdelta2+ T cells may contribute to adaptive immunity to mycobacterial infections.
- Published
- 2002
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