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Bacteriophages in live virus vaccines: lack of evidence for effects on the genome of rhesus monkeys.
- Source :
-
Science (New York, N.Y.) [Science] 1977 Jul 29; Vol. 197 (4302), pp. 469-70. - Publication Year :
- 1977
-
Abstract
- Four juvenile rhesus monkeys were inoculated with 10(12) plaque-forming units of the bacteriophage phiV1 isolated from live virus vaccines. After phiV1 had been cleared from the blood, DNA's were isolated from the livers and kidneys and analyzed for the presence of bacteriophage by plaque assays, and for the presence of phiV1 DNA by DNA-DNA reassociation kinetics. No evidence was found for persistence of the bacteriophage or for replication of the phage genome in these rhesus monkeys.
Details
- Language :
- English
- ISSN :
- 0036-8075
- Volume :
- 197
- Issue :
- 4302
- Database :
- MEDLINE
- Journal :
- Science (New York, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 406673
- Full Text :
- https://doi.org/10.1126/science.406673