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Your search keyword '"Kaufmann, Gunnar F."' showing total 3 results
Start Over Author "Kaufmann, Gunnar F." Publisher american association for the advancement of science
3 results on '"Kaufmann, Gunnar F."'

2. Deeply inverted electron-hole recombination in a luminescent antibody-stilbene complex

Author

Debler, Erik W., Kaufmann, Gunnar F., Meijler, Michael M., Heine, Andreas, Mee, Jenny M., Pljevaljcic, Goran, Di Bilio, Angel J., Schultz, Peter G., Millar, David P., Janda, Kim D., Wilson, Ian A., Gray, Harry B., and Lerner, Richard A.

Subjects
Antibodies -- Optical properties, Viral antibodies -- Optical properties
Published
2008

3. Modulation of Gene Expression via Disruption of NF-κB Signaling by a Bacterial Small Molecule.

Author

Kravchenko, Vladimir V., Kaufmann, Gunnar F., Mathison, John C., Scott, David A., Katz, Alexander Z., Grauer, David C., Lehmann, Mandy, Meijler, Michael M., Janda, Kim D., and Ulevitch, Richard J.

Subjects
*IMMUNOREGULATION, *TRANSCRIPTION factors, *PATHOGENIC bacteria, *LACTONES, *MAMMAL genetics, *BACTERIAL genetics, *CYTOKINES, *PSEUDOMONAS aeruginosa, *IMMUNE system, *BACTERIAL diseases, *CYSTIC fibrosis
Abstract

The control of innate immune responses through activation of the nuclear transcription factor NF-B is essential for the elimination of invading microbial pathogens. We showed that the bacterial N-(3-oxo-dodecanoyl) homoserine lactone (C12) selectively impairs the regulation of NF-κB functions in activated mammalian cells. The consequence is specific repression of stimulus-mediated induction of NF-κB-responsive genes encoding inflammatory cytokines and other immune regulators. These findings uncover a strategy by which C12-producing opportunistic pathogens, such as Pseudomonas aeruginosa, attenuate the innate immune system to establish and maintain local persistent infection in humans, for example, in cystic fibrosis patients. [ABSTRACT FROM AUTHOR]

Published
2008
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