Back to Search
Start Over
Modulation of Gene Expression via Disruption of NF-κB Signaling by a Bacterial Small Molecule.
- Source :
-
Science . 7/11/2008, Vol. 321 Issue 5886, p259-263. 5p. 3 Graphs. - Publication Year :
- 2008
-
Abstract
- The control of innate immune responses through activation of the nuclear transcription factor NF-B is essential for the elimination of invading microbial pathogens. We showed that the bacterial N-(3-oxo-dodecanoyl) homoserine lactone (C12) selectively impairs the regulation of NF-κB functions in activated mammalian cells. The consequence is specific repression of stimulus-mediated induction of NF-κB-responsive genes encoding inflammatory cytokines and other immune regulators. These findings uncover a strategy by which C12-producing opportunistic pathogens, such as Pseudomonas aeruginosa, attenuate the innate immune system to establish and maintain local persistent infection in humans, for example, in cystic fibrosis patients. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00368075
- Volume :
- 321
- Issue :
- 5886
- Database :
- Academic Search Index
- Journal :
- Science
- Publication Type :
- Academic Journal
- Accession number :
- 33763837
- Full Text :
- https://doi.org/10.1126/science.1156499