1. CMV-specific T cells generated from naïve T cells recognize atypical epitopes and may be protective in vivo.
- Author
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Hanley, Patrick J., Melenhorst, Jan J., Nikiforow, Sarah, Scheinberg, Phillip, Blaney, James W., Demmler-Harrison, Gail, Cruz, C. Russell, Lam, Sharon, Krance, Robert A., Leung, Kathryn S., Martinez, Caridad A., Hao Liu, Douek, Daniel C., Heslop, Helen E., Rooney, Cliona M., Shpall, Elizabeth J., Barrett, A. John, Rodgers, John R., and Bollard, Catherine M.
- Subjects
CYTOMEGALOVIRUSES ,T cells ,TRANSPLANTATION immunology ,PREVENTIVE medicine ,CORD blood - Abstract
The article looks at a study regarding adoptive transfer of cytomegalovirus (CMV)–specific T cells which can restore antiviral immunity after transplantation. It mentions availability of virus-specific T cells for immunoprophylaxis and CMV-seropositive individuals also had T cells recognizing these atypical epitopes and recipients of cord blood (CB) grafts. It also mentions naïve donor– derived virus-specific T cells recognized atypical epitopes were associated with prolonged periods of CMV.
- Published
- 2015
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