CMV-specific T cells generated from naïve T cells recognize atypical epitopes and may be protective in vivo.

The article looks at a study regarding adoptive transfer of cytomegalovirus (CMV)–specific T cells which can restore antiviral immunity after transplantation. It mentions availability of virus-specific T cells for immunoprophylaxis and CMV-seropositive individuals also had T cells recognizing these atypical epitopes and recipients of cord blood (CB) grafts. It also mentions naïve donor– derived virus-specific T cells recognized atypical epitopes were associated with prolonged periods of CMV.