1. Recent developments in limited stage small cell lung cancer
- Author
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Lisa J. Sudmeier, Corinne Faivre-Finn, Kristin Higgins, and Sophia Gorgens
- Subjects
Oncology ,Limited stage ,medicine.medical_specialty ,medicine.medical_treatment ,Review Article ,030218 nuclear medicine & medical imaging ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,law ,Internal medicine ,Medicine ,Lung cancer ,Etoposide ,Limited Stage ,Chemotherapy ,Manchester Cancer Research Centre ,business.industry ,ResearchInstitutes_Networks_Beacons/mcrc ,Small cell lung cancer (SCLC) ,medicine.disease ,Prophylactic cranial irradiation (PCI) ,Regimen ,030220 oncology & carcinogenesis ,Conventional PCI ,Immunotherapy ,Prophylactic cranial irradiation ,business ,medicine.drug - Abstract
Limited stage small cell lung cancer (LS-SCLC) remains a challenging disease, with 5-year overall survival ranging from 30–35% with current standard of care treatment consisting of thoracic radiation to 45 Gy in 30 fractions delivered twice daily, with concurrent platinum/etoposide chemotherapy, followed by prophylactic cranial irradiation (PCI). The randomized, phase III CONVERT study confirmed 45 Gy delivered twice daily to be the optimal radiation fractionation regimen, without significantly increased toxicity when compared to daily radiation to 66 Gy. Immunotherapy is now being studied in addition to chemoradiation, in both the concurrent and consolidative setting. These randomized trials are ongoing. Additionally, the role of PCI compared to MRI surveillance is being evaluated in patients with LS-SCLC in both the North America and Europe. Ideally these ongoing studies will continue to improve outcomes for LS-SCLC.
- Published
- 2019