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Recent developments in limited stage small cell lung cancer
- Source :
- Higgins, K A, Gorgens, S, Sudmeier, L J & Faivre-Finn, C 2019, ' Recent developments in limited stage small cell lung cancer ', Translational Lung Cancer Research, vol. 8, pp. S147-S152 . https://doi.org/10.21037/tlcr.2019.05.13
- Publication Year :
- 2019
- Publisher :
- AME Publishing Company, 2019.
-
Abstract
- Limited stage small cell lung cancer (LS-SCLC) remains a challenging disease, with 5-year overall survival ranging from 30–35% with current standard of care treatment consisting of thoracic radiation to 45 Gy in 30 fractions delivered twice daily, with concurrent platinum/etoposide chemotherapy, followed by prophylactic cranial irradiation (PCI). The randomized, phase III CONVERT study confirmed 45 Gy delivered twice daily to be the optimal radiation fractionation regimen, without significantly increased toxicity when compared to daily radiation to 66 Gy. Immunotherapy is now being studied in addition to chemoradiation, in both the concurrent and consolidative setting. These randomized trials are ongoing. Additionally, the role of PCI compared to MRI surveillance is being evaluated in patients with LS-SCLC in both the North America and Europe. Ideally these ongoing studies will continue to improve outcomes for LS-SCLC.
- Subjects :
- Oncology
Limited stage
medicine.medical_specialty
medicine.medical_treatment
Review Article
030218 nuclear medicine & medical imaging
law.invention
03 medical and health sciences
0302 clinical medicine
Randomized controlled trial
law
Internal medicine
Medicine
Lung cancer
Etoposide
Limited Stage
Chemotherapy
Manchester Cancer Research Centre
business.industry
ResearchInstitutes_Networks_Beacons/mcrc
Small cell lung cancer (SCLC)
medicine.disease
Prophylactic cranial irradiation (PCI)
Regimen
030220 oncology & carcinogenesis
Conventional PCI
Immunotherapy
Prophylactic cranial irradiation
business
medicine.drug
Subjects
Details
- ISSN :
- 22264477 and 22186751
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Translational Lung Cancer Research
- Accession number :
- edsair.doi.dedup.....99e11a26fcd4b8a5ce96257e8a6b3727