1. CNP infusion attenuates cardiac dysfunction and inflammation in myocarditis
- Author
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Obata, Hiroaki, Yanagawa, Bobby, Tanaka, Koichi, Ohnishi, Shunsuke, Kataoka, Masaharu, Miyahara, Yoshinori, Ishibashi-Ueda, Hatsue, Kodama, Makoto, Aizawa, Yoshifusa, Kangawa, Kenji, and Nagaya, Noritoshi
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MYOCARDITIS , *PEPTIDES , *MYOSIN , *NEOVASCULARIZATION - Abstract
Abstract: Myocarditis is an acute inflammatory disease of the myocardium for which there is currently no specific therapy. We investigated the therapeutic potential of C-type natriuretic peptide (CNP) in acute experimental autoimmune myocarditis. One week after injection of porcine myosin into male Lewis rats, CNP (0.05μg/kg/min) was continuously administered for 2 weeks. CNP infusion significantly increased maximum dP/dt, decreased left ventricular end-diastolic pressure, and improved fractional shortening compared with vehicle administration. In vehicle-treated hearts, severe necrosis and marked infiltration of CD68-positive inflammatory cells were observed. Myocardial and serum levels of monocyte chemoattractant protein-1 were elevated in myocarditis. However, these changes were attenuated by CNP infusion. In addition, treatment with CNP significantly increased myocardial capillary density. Guanylyl cyclase-B, a receptor for CNP, was expressed in myocarditic heart, and cyclic guanosine monophosphate was elevated by CNP infusion. In conclusion, CNP infusion attenuated cardiac function in acute myocarditis through anti-inflammatory and angiogenic effects. [Copyright &y& Elsevier]
- Published
- 2007
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