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CNP infusion attenuates cardiac dysfunction and inflammation in myocarditis
- Source :
-
Biochemical & Biophysical Research Communications . Apr2007, Vol. 356 Issue 1, p60-66. 7p. - Publication Year :
- 2007
-
Abstract
- Abstract: Myocarditis is an acute inflammatory disease of the myocardium for which there is currently no specific therapy. We investigated the therapeutic potential of C-type natriuretic peptide (CNP) in acute experimental autoimmune myocarditis. One week after injection of porcine myosin into male Lewis rats, CNP (0.05μg/kg/min) was continuously administered for 2 weeks. CNP infusion significantly increased maximum dP/dt, decreased left ventricular end-diastolic pressure, and improved fractional shortening compared with vehicle administration. In vehicle-treated hearts, severe necrosis and marked infiltration of CD68-positive inflammatory cells were observed. Myocardial and serum levels of monocyte chemoattractant protein-1 were elevated in myocarditis. However, these changes were attenuated by CNP infusion. In addition, treatment with CNP significantly increased myocardial capillary density. Guanylyl cyclase-B, a receptor for CNP, was expressed in myocarditic heart, and cyclic guanosine monophosphate was elevated by CNP infusion. In conclusion, CNP infusion attenuated cardiac function in acute myocarditis through anti-inflammatory and angiogenic effects. [Copyright &y& Elsevier]
- Subjects :
- *MYOCARDITIS
*PEPTIDES
*MYOSIN
*NEOVASCULARIZATION
Subjects
Details
- Language :
- English
- ISSN :
- 0006291X
- Volume :
- 356
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Biochemical & Biophysical Research Communications
- Publication Type :
- Academic Journal
- Accession number :
- 24381259
- Full Text :
- https://doi.org/10.1016/j.bbrc.2007.02.085