1,939 results on '"psychopathology"'
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2. Emotion Regulation and Academic Burnout among Youth: A Quantitative Meta-Analysis
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Ioana Alexandra Iuga and Oana Alexandra David
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Emotion regulation (ER) represents an important factor in youth's academic wellbeing even in contexts that are not characterized by outstanding levels of academic stress. Effective ER not only enhances learning and, consequentially, improves youths' academic achievement, but can also serve as a protective factor against academic burnout. The relationship between ER and academic burnout is complex and varies across studies. This meta-analysis examines the connection between ER strategies and student burnout, considering a series of influencing factors. Data analysis involved a random effects meta-analytic approach, assessing heterogeneity and employing multiple methods to address publication bias, along with meta-regression for continuous moderating variables (quality, female percentage and mean age) and subgroup analyses for categorical moderating variables (sample grade level). According to our findings, adaptive ER strategies are negatively associated with overall burnout scores, whereas ER difficulties are positively associated with burnout and its dimensions, comprising emotional exhaustion, cynicism, and lack of efficacy. These results suggest the nuanced role of ER in psychopathology and well-being. We also identified moderating factors such as mean age, grade level and gender composition of the sample in shaping these associations. This study highlights the need for the expansion of the body of literature concerning ER and academic burnout, that would allow for particularized analyses, along with context-specific ER research and consistent measurement approaches in understanding academic burnout. Despite methodological limitations, our findings contribute to a deeper understanding of ER's intricate relationship with student burnout, guiding future research in this field.
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- 2024
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3. Predicting Academic Dishonesty: The Role of Psychopathic Traits, Perception of Academic Dishonesty, Moral Disengagement and Motivation
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Chiara Luisa Sirca and Eva Billen
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This study conducted on a sample of 295 Dutch and Italian undergraduate and graduate students aims to investigate how psychopathic personality traits (meanness, boldness and disinhibition) may lead to cheating behavior, and to study whether there are correlations between psychopathic traits, motivation, moral disengagement, the perception of seriousness of academic dishonesty and frequency of academic dishonesty to try to better understand what causes students to cheat and engage in dishonest conduct. Results confirmed the key role of psychopathic traits, particularly the disinhibition aspect in predicting academic dishonesty. In addition, it was shown that students' perceptions of what constitutes academic dishonesty and what does not are also important in predicting the frequency of dishonest behavior. Furthermore, the role of motivation and moral disengagement in predicting and mediating the relationship between traits of psychopathy and academic dishonesty were analyzed through mediation and regression analysis.
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- 2024
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4. Measuring Unipolar Traits with Continuous Response Items: Some Methodological and Substantive Developments
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Pere J. Ferrando, Fabia Morales-Vives, and Ana Hernández-Dorado
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In recent years, some models for binary and graded format responses have been proposed to assess unipolar variables or "quasi-traits." These studies have mainly focused on clinical variables that have traditionally been treated as bipolar traits. In the present study, we have made a proposal for unipolar traits measured with continuous response items. The proposed log-logistic continuous unipolar model (LL-C) is remarkably simple and is more similar to the original binary formulation than the graded extensions, which is an advantage. Furthermore, considering that irrational, extreme, or polarizing beliefs could be another domain of unipolar variables, we have applied this proposal to an empirical example of superstitious beliefs. The results suggest that, in certain cases, the standard linear model can be a good approximation to the LL-C model in terms of parameter estimation and goodness of fit, but not trait estimates and their accuracy. The results also show the importance of considering the unipolar nature of this kind of trait when predicting criterion variables, since the validity results were clearly different.
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- 2024
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5. The Big Three Perfectionism Scale: Validation of the Polish Version
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Konrad Piotrowski, Aleksandra Nowicka, Kamil Janowicz, and Martin M. Smith
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The Big Three Perfectionism Scale (BTPS) was created to integrate different aspects of perfectionism, including the newly conceptualized concept of narcissistic perfectionism. The goal of our two studies (N = 1341) was to examine the psychometric properties of the Polish adaptation of the BTPS, supporting the validity and portability of the measure. The studies were conducted among people who had a child, thus contributing to a better understanding of parental perfectionism, one of the key factors influencing parental well-being and a child's functioning. Our analyses included investigating the structure of the scale, intercorrelations between subscales, reliability, and convergent validity by correlating BTPS scores with other measures of perfectionism and correlates of psychopathology (borderline symptoms) and parental difficulties (parental stress and parental burnout). Results supported the structure of the original BTPS. As predicted, confirmatory factor analysis indicated that items comprising the Polish adaptation of the questionnaire, like the original version, measure three related but specific aspects of perfectionism: rigid perfectionism, self-critical perfectionism, and narcissistic perfectionism. The three dimensions were also found to be specifically related to the difficulties experienced by parents. Further, the Polish version of the BTPS was found to have good internal reliability and validity. Our results from two independent Polish samples suggest that the Polish version of the BTPS is a psychometrically robust measure of perfectionism for assessing the three perfectionism factors.
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- 2024
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6. Context-Dependent Approach and Avoidance Behavioral Profiles as Predictors of Psychopathology
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Caroline M. Kelsey, Anna Fasman, Kelsey Quigley, Kelli Dickerson, Michelle Bosquet Enlow, and Charles A. Nelson
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Inhibition (a temperamental profile characterized by elevated levels of avoidance behaviors) is associated with increased likelihood for developing anxiety and depression, whereas exuberance (a temperamental profile characterized by elevated levels of approach behaviors) is associated with increased likelihood for developing externalizing conditions (e.g., attention deficit/hyperactivity disorder and conduct disorder). However, not all children who exhibit high levels of approach or avoidance behaviors develop emotional or behavioral problems. In this preregistered study, we assessed context-dependent profiles of approach and avoidance behaviors in 3-year-old children (N = 366). Using latent profile analysis, four groups were identified: nonsocial approachers, social approachers, social avoiders, and nonsocial avoiders. Analyses revealed that there were minimal differences in internalizing and externalizing symptoms across the four context-dependent groups. However, exploratory analyses assessed whether high levels of approach or avoidance combined across contexts, similar to findings reported in prior work, were related to psychopathology. Children identified as high in avoidance behavior at 3 years of age were more likely to show internalizing symptoms at 3 years of age but not at 5 years of age. Children high in approach were more likely to meet criteria for anxiety and externalizing disorders by age 5 years. These findings further our understanding of individual differences in how young children adjust their behavior based on contextual cues and may inform methods for identifying children at increased likelihood for the development of emotional and behavioral problems.
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- 2024
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7. Biederman's Contribution to the Understanding of Executive Function in ADHD
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Russell Schachar and Jennifer Crosbie
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Objective: To examine the theoretical and empirical contribution of Joe Biederman and his colleagues to the understanding of executive function (EF) and ADHD. Method: We searched PubMed for references to EF in Biederman's publications and conducted a narrative review of this literature. Results: In 50 or more papers using neuropsychological tests, rating scales and measures of mind wandering, Biederman demonstrated that EF are evident in ADHD and closely linked to its underlying neurobiological and genetic risk. He argued that EF need to be monitoring to ensure comprehensive assessment and treatment, but could not be used as a diagnostic proxy. Conclusion: Biederman built an innovative and impressive collaboration to address the issue of EF in ADHD. His work shows a commitment to understanding of EF in order to improve patient care. Biederman laid down a roadmap for research in ADHD and EF for the rest of the field to follow.
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- 2024
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8. The Child Behavior Check List Usefulness in Screening for Severe Psychopathology in Youth: A Narrative Literature Review
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Pascal Chavannes and Martin Gignac
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Objective: This article will review the use of the CBCL to diagnose youth with psychopathological disorders focusing on: ADHD, Mood Disorders, Autism Spectrum disorders, and Disruptive Disorders. Method: Using a narrative review approach, we investigate the usefulness of the CBCL as a screening tool to detect childhood onset psychopathology across different diagnostic syndromes. Results: The available literature supports the use of the CBCL for ADHD screening and as a measure of ADHD severity. While some studies support a specific profile linked with childhood bipolar disorder, replication studies for this profile found mixed results. The CBCL was also found to be useful in screening for patients presenting with Autism Spectrum Disorders, Conduct Disorder, and Childhood Bipolar Disorder all of which presents with more severely impaired scores. Conclusion: The CBCL holds promise as a screening tool for childhood psychopathology.
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- 2024
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9. The Youth Mental Health Crisis and the Subjectification of Wellbeing in Singapore Schools
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Daniel P. S. Goh and Aaron Koh
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The news of a 16-year old teenager hacking a 13-year old boy to death in a toilet unprovoked in a secondary school in Singapore shook the whole nation in July 2021. In this article, we analyze the institutionalizing responses to the growing sense of youth mental health crisis in Singapore, catalyzed by River Valley High School incident, as the subjectification of wellbeing. We argue, firstly, that the national schools have become the main site for the production of networked surveillance and internalization of wellbeing. We examine the inclusive production of subjects characterized by varying levels of wellbeing in a rehabilitative social system exercising authority and control. Secondly, we argue that a totalizing system of surveillance and internalization is emerging in a technocratic heterotopia. We conclude by discussing interdisciplinary and intersectional alternative approaches emerging from the heterotopic space of the school.
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- 2024
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10. A Comparison of Two Teacher Trainings on Student Anxiety
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Institute of Education Sciences (ED), Golda S. Ginsburg, Jeffrey E. Pella, Anneliese DeVito, and Grace Chan
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The purpose of this study was to compare the impact of two teacher trainings, both focused on identifying student anxiety and implementing empirically supported anxiety reduction strategies in the classroom. A comparison of teachers' satisfaction with their training was examined along with pre-post training changes on measures of teachers' knowledge and use of evidence-based anxiety reduction strategies, perceived confidence in assisting students with anxiety, and teaching self-efficacy. Volunteer elementary teachers in New England USA were randomized to receive either a six-hour interactive training (Teacher Anxiety Program for Elementary Students; TAPES; n = 41) or a three-hour didactic (Teacher Anxiety Training; TAT; n = 37). Fifty-four teachers completed their respective training (mean age 40.9; SD = 10.2; 98% female; 96% White). Results from t-tests indicated that levels of training satisfaction were high and similar across trainings. Mixed-design ANOVA analyses found that teachers receiving both trainings showed significant improvements in teacher knowledge and use of anxiety reduction strategies, confidence, and self-efficacy. Teachers receiving TAPES, compared to TAT, showed greater improvements in their knowledge of anxiety reduction strategies. Findings highlight the need and perceived value of training teachers on topics related to identifying and managing student anxiety.
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- 2024
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11. Relative Brain Age Is Associated with Socioeconomic Status and Anxiety/Depression Problems in Youth
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Jacob W. Cohen, Bruce Ramphal, Mariah DeSerisy, Yihong Zhao, David Pagliaccio, Stan Colcombe, Michael P. Milham, and Amy E. Margolis
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Brain age, a measure of biological aging in the brain, has been linked to psychiatric illness, principally in adult populations. Components of socioeconomic status (SES) associate with differences in brain structure and psychiatric risk across the lifespan. This study aimed to investigate the influence of SES on brain aging in childhood and adolescence, a period of rapid neurodevelopment and peak onset for many psychiatric disorders. We reanalyzed data from the Healthy Brain Network to examine the influence of SES components (occupational prestige, public assistance enrollment, parent education, and household income-to-needs ratio [INR]) on relative brain age (RBA). Analyses included 470 youth (5-17 years; 61.3% men), self-identifying as White (55%), African American (15%), Hispanic (9%), or multiracial (17.2%). Household income was 3.95 ± 2.33 (mean ± SD) times the federal poverty threshold. RBA quantified differences between chronological age and brain age using covariation patterns of morphological features and total volumes. We also examined associations between RBA and psychiatric symptoms (Child Behavior Checklist [CBCL]). Models covaried for sex, scan location, and parent psychiatric diagnoses. In a linear regression, lower RBA is associated with lower parent occupational prestige (p = 0.01), lower public assistance enrollment (p = 0.03), and more parent psychiatric diagnoses (p = 0.01), but not parent education or INR. Lower parent occupational prestige (p = 0.02) and lower RBA (p = 0.04) are associated with higher CBCL anxious/depressed scores. Our findings underscore the importance of including SES components in developmental brain research. Delayed brain aging may represent a potential biological pathway from SES to psychiatric risk.
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- 2024
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12. Those Who Gift Only Themselves: An Analysis of Gifted Narcissists as Ultimate Self-Transactionalists
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Ophélie A. Desmet and Robert J. Sternberg
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Researchers have argued that many leaders, such as CEOs and politicians, tend to possess narcissistic traits. At healthy and productive levels, narcissistic traits, such as self-promotion, may actually be an advantage to achieving success in some fields. Yet, few researchers have explored gifted narcissists as a twice-exceptionality. This article discusses the gifted narcissist profile and grandiose narcissism in particular. Following a brief introduction to key terms, the gifted narcissist profile is explored through the augmented theory of successful intelligence. The impact of giftedness on individuals with a narcissistic personality disorder is discussed in terms of positive and negative effects. Presidents, autocratic leaders, and cult leaders are presented as examples of gifted grandiose narcissists.
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- 2024
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13. Targeting Caregiver Psychopathology in Parent Management Training for Adolescents: A Scoping Review of Commercially Available Treatment Resources
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Austen McGuire, Christina M. Amaro, Mehar N. Singh, and Shaquanna Brown
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Background: While parent management training (PMT) has been shown to be an effective treatment for adolescents with externalizing concerns, evidence suggests that effectiveness is not equitable across all types of families. Research suggests that caregiver psychopathology may adversely affect PMT success for adolescents. However, it remains unclear whether research on caregiver psychopathology is integrated within adolescent PMT resources (e.g., treatment manuals). Objective: A scoping review of commercially available, clinician focused PMT resources was conducted to assess for information on caregiver psychopathology and clinical guidance for addressing caregiver psychopathology. Methods: A search for commercially available resources was conducted among national treatment databases and book resource websites. Information on caregiver psychopathology was extracted from individual sessions of the PMT resources. Results: Seven treatment resources met inclusion criteria. The majority of the treatment resources made at least one explicit comment that caregiver psychopathology may impact the course of treatment. There was very limited mention of caregiver psychopathology in skill building sections of the resources. Conclusions: While most resources mentioned caregiver psychopathology, these comments lacked breadth and depth in providing clinicians with recommendations on how to tailor treatment to caregivers' needs. Recommendations are provided for how PMT programs might be improved in the future to support clinicians when faced with caregiver psychopathology by recognizing inequities and lack of diversity in resource development, using a transdiagnostic perspective (including a transdiagnostic approach to assessment of caregiver psychopathology), and integrating caregiver skill development.
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- 2024
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14. Exploring the Ability of Educators to Identify Behaviors Indicative of Emerging Psychopathologies in Elementary School Students: Assessing the Use of a Novel Vignette Measure
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Damian Page and Todd Cunningham
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The present study sought to assess the ability of teachers to identify emerging mental health disorders through a novel vignette measure. Canadian certified primary grade teachers (N = 101) completed a survey that included a novel vignette measure. Participants rated the severity of fictitious student behaviors depicted in several vignettes and their accuracy was calculated based on how closely their ratings matched the severity of symptoms depicted. Accuracy estimates derived through this measure differed considerably from previous vignette measure paradigms, producing much lower estimates of identification accuracy. A binomial logistics regression indicated that neither the gender nor pathology depicted in the vignettes significantly influenced rating accuracy. This novel vignette measure may represent a quick and effective means of assessing the accuracy of teachers in identifying emerging mental health disorders in their students.
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- 2024
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15. The Application of the Formal Elements Art Therapy Scale in the Person-in-the-Rain Drawing Test
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Pui-Kwan Au, Calvin Kai-Ching Yu, and Siu-Sing Wong
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The Person-in-the-Rain (PITR) drawing scoring system primarily assesses stress, excluding consideration of color usage. In contrast, the Formal Elements Art Therapy Scale (FEATS) effectively evaluates psychopathological disorders and provides a comprehensive assessment of color usage. This study aimed to: (1) develop an alternative scoring system for PITR by modifying FEATS, (2) explore the clinical significance of color in PITR by examining its relationship with Depression Anxiety Stress Scales (DASS-21), and (3) determine if color mediates the relationship between DASS-21 and FEATS-based PITR ratings. We recruited 61 college students who completed PITR and DASS-21. PITR drawings were coded using modified FEATS. Findings suggest that the modified FEATS scoring system provides clinically meaningful information for assessing stress, coping mechanisms, anxiety, and depression.
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- 2024
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16. The Longitudinal Impact of Pre- and Postnatal Maternal Depression and Anxiety on Children's Cognitive and Language Development
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Noriyeh Rahbari, Monique Sénéchal, Blanca Bolea, and Ashley Wazana
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We investigated the longitudinal associations among maternal pre- and postnatal depression, maternal anxiety, and children's language and cognitive development followed from 15 to 61 months. Furthermore, we assessed the protective role of children's early print experiences with books against the adverse effect of maternal depression on language development. Data for mothers and children (51.7% boys, 95% White, N = 11,662) were from the Avon Longitudinal Study of Parents and Children. Prenatal maternal depression held an adverse association with child language ([beta] = -0.16, p = 0.002). Moreover, the risk was greater for girls than boys ([beta] = 0.19, p = 0.02). In addition, prenatal depression was significantly and negatively associated with child verbal intelligence quotient ([beta] = -0.11, p = 0.02) and performance intelligence quotient ([beta] = -0.12, p = 0.01). In contrast, postnatal depression or anxiety were not unique predictors of child outcomes. Importantly, children's early experiences with books, as measured by the reported frequency of parent-child shared reading, moderated the negative association between maternal depression and child language development ([beta] = 0.30, p < 0.001). Although modest in size, these findings inform models of child risk and resilience related to maternal psychopathology. The results also have implications for clinical programs as well as for prevention and intervention studies focusing on at-home early literacy.
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- 2024
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17. Reinforcement Sensitivity Theory and Externalizing Problems across Early Adolescence: Testing Within-Person Reciprocal Associations
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Nolan E. Ramer, Gretchen R. Perhamus, and Craig R. Colder
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Temperament and externalizing problems are closely linked, but research on how they codevelop across adolescence remains sparse and equivocal. Reinforcement sensitivity theory (RST) provides a useful framework for understanding temperament and externalizing problems associations. During adolescence, oppositional problems are posited to be linked to an overactive behavioral approach system (BAS) while conduct problems are linked to an underactive behavioral inhibition system (BIS). However, this research mostly uses adult samples and cross-sectional designs and tests only between-person associations. Moreover, most studies typically test only one direction of effects (i.e., temperament predicts externalizing problems) and do not consider alternative models of associations, such as reciprocal associations. To address these limitations, we use three annual waves of a longitudinal, community-based sample of 387 early adolescents (mean Wave 1 age = 11.61 years, 55% female, 83% non-Hispanic White) to test reciprocal associations between BIS and BAS and oppositional and conduct problems. Latent curve models with structured residuals are used to test hypotheses and disaggregate between- and within-person associations. Evidence supports within-person reciprocal associations between BAS and oppositional problems and between BIS and combined conduct and oppositional problems. Results potentially inform developmental theories of temperament and externalizing problems linkages and interventions with adolescents who are engaging in oppositional problems and more severe conduct problems.
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- 2024
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18. Longitudinal Measurement Invariance of the ASEBA Youth/Adult Self-Reports Across the Transition From Adolescence to Adulthood.
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Moriarity, Daniel P, Mac Giollabhui, Naoise, Cardoso Melo, Dener, and Hartman, Catharina
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Clinical and Health Psychology ,Psychology ,Behavioral and Social Science ,Mental Health ,Clinical Research ,Pediatric ,Depression ,Mental Illness ,Brain Disorders ,Mental health ,Good Health and Well Being ,measurement ,measurement invariance ,longitudinal ,adolescent ,adult ,developmental ,psychopathology ,Clinical Psychology ,Applied and developmental psychology ,Biological psychology - Abstract
The ability to quantify within-person changes in mental health is central to the mission of clinical psychology. Typically, this is done using total or mean scores on symptom measures; however, this approach assumes that measures quantify the same construct, the same way, each time the measure is completed. Without this quality, termed longitudinal measurement invariance, an observed difference between timepoints might be partially attributable to changing measurement properties rather than changes in comparable symptom measurements. This concern is amplified in research using different forms of a measure across developmental periods due to potential differences in reporting styles, item-wording, and developmental context. This study provides the strongest support for the longitudinal measurement invariance of the Anxiety Scale, Depression/Affective Problems: Cognitive Subscale, and the Attention Deficit Hyperactivity Disorder (ADHD) Scale; moderate support for the Depression/Affective Problems Scale and the Somatic Scale, and poor support for the Depression/Affective Problems: Somatic Symptoms Subscale of the Dutch Achenbach System of Empirically Based Assessment Youth Self-Report and Adult Self-Report in a sample of 1,309 individuals (N = 1,090 population-based, N = 219 clinic-based/referred to an outpatient clinic before age 11 years) across six waves of data (mean ages = 11 years at Wave 1 and 26 years at Wave 6).
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- 2024
19. The Association Between Adverse Childhood Experiences (ACEs), Bullying Victimization, and Internalizing and Externalizing Problems Among Early Adolescents: Examining Cumulative and Interactive Associations
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Trompeter, Nora, Testa, Alexander, Raney, Julia H, Jackson, Dylan B, Al-shoaibi, Abubakr AA, Ganson, Kyle T, Shao, Iris Yuefan, and Nagata, Jason M
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Psychology ,Clinical and Health Psychology ,Social and Personality Psychology ,Applied and Developmental Psychology ,Prevention ,Youth Violence ,Youth Violence Prevention ,Pediatric ,Mental Health ,Behavioral and Social Science ,Violence Research ,2.3 Psychological ,social and economic factors ,Aetiology ,Mental health ,Good Health and Well Being ,Humans ,Adolescent ,Female ,Male ,Adverse Childhood Experiences ,Ethnicity ,Minority Groups ,Bullying ,Crime Victims ,Adverse childhood experiences ,Peer victimization ,Psychopathology ,Specialist Studies in Education ,Developmental & Child Psychology ,Applied and developmental psychology ,Clinical and health psychology ,Social and personality psychology - Abstract
Both adverse childhood experiences (ACEs) and bullying victimization are linked with mental health problems in adolescents. However, little is known about the overlap between the two factors and how this impacts adolescent mental health problems (i.e., internalizing and externalizing problems). The current study analyzed data from 8,085 participants (47.7% female; 44.1% racial/ethnic minority) in the Adolescent Brain Cognitive Development (ABCD) study, baseline (2016-2018, ages 9-10 years) to Year 2. Regression analyses were used to estimate associations between ACEs, bullying victimization and mental health problems, respectively, adjusting for sex, race/ethnicity, country of birth, household income, parental education, and study site. The findings showed that both ACEs and bullying victimization were independently associated with higher internalizing and higher externalizing problems. However, no significant interaction was found between ACEs and bullying victimization. Overall, the results align with the cumulative risk model of adversity, linking cumulative ACEs and bullying victimization to internalizing and externalizing problems in early adolescents.
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- 2024
20. Contexts of urgency may go beyond emotion.
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Elliott, Matthew, John, Oliver, Allen, J, and Johnson, Sheri
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emotion ,impulsivity ,psychopathology ,self-control ,urgency - Abstract
INTRODUCTION: Urgency has been defined as the tendency towards rash speech and behavior in the context of emotion. Measures of Urgency have been found to have robust predictive power for psychopathologies and problematic behaviors. In the current study, we question whether emotions are unique drivers of urgency, or if emotions are potent exemplars of contexts that lead to rash speech and behavior. The Emotion Specific model and the Broader Contexts model correspond with these two conceptualizations of urgency, and they frame our pre-registered hypotheses. METHODS: Participants from two well-powered samples (n = 600,n = 588) completed 9 modified items from the Urgency and Positive Urgency scales to assess rash responses in each of four contexts - Upset, Excited, Tired, and Hungry - and a fifth In General set. After data cleaning, we used principal components analysis to construct a unidimensional, 4-item set that was applied to capture impulsive behavior across the five contexts. RESULTS: We found that this research tool, called the Contexts of Impulsive Behaviors (CIBS), replicated in the second dataset, and it had adequate internal reliability in both samples. Although the Emotion Specific model was supported by the fact that the Upset context had a greater mean and greater variance than the Tired and Hungry contexts, most results supported the Broader Contexts model. That is, CIBS contexts were highly intercorrelated, and bivariate correlations with psychopathology were not significantly different across contexts. In partial correlations, effects of the Upset and Excited contexts were partially or fully statistically mediated by the Tired and Hungry contexts. DISCUSSION: These findings suggest that emotions are potent contexts for impulsive behaviors. At the same time, those with high urgency are vulnerable to impulsivity in other contexts, such as fatigue and hunger, that challenge the regulatory functions of the prefrontal cortex. Limitations, future directions, and clinical implications are discussed.
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- 2024
21. Dyadic Psychopathology and Adjustment to Parenthood in Families With and Without Eating Disorder History—Findings From a Longitudinal Study.
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Throm, Jana Katharina, Dörsam, Annica Franziska, Micali, Nadia, Preissl, Hubert, and Giel, Katrin Elisabeth
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ABSTRACT Objective Method Results Discussion Transition to parenthood is a vulnerable period for individual health and partnership quality. This study investigated parental health and partnership after childbirth in families with and without maternal eating disorder (ED) history. We report longitudinal data on parental ED psychopathology, depressive symptoms, and adjustment, including dyadic associations.Data derived from the prospective multi‐method cohort study EMKIE. Women with (n = 24) and without (n = 33) ED history and their partners took part from late pregnancy to 10 months postpartum and completed the Eating Disorder Examination Questionnaire, the Patient Health Questionnaire, and the Maternal Adjustment and Maternal Attitudes Questionnaire or the paternal equivalent.ED psychopathology increased in mothers in both groups. Mothers in the ED group had more severe ED psychopathology, higher depression scores, and lower levels of adjustment to motherhood compared to the control group across all measurement points. No group differences emerged between partners, but ED psychopathology increased in partners of women with ED history over time. A negative correlation between maternal ED severity and paternal adjustment was observed in the ED group.After childbirth, mothers with ED history experienced mental health deterioration and adjustment difficulties and fathers struggled with paternal adjustment if their partner was affected by severe ED symptoms. These results emphasize the need for close monitoring and consistent care of women with ED during this vulnerable period and highlight adjustment needs of partners of severely affected women. Further qualitative approaches are needed to deepen the knowledge of paternal experiences during this period. [ABSTRACT FROM AUTHOR]
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- 2024
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22. The phenomenology of psychedelic temporality: current knowledge, open questions, and clinical applications.
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Miceli McMillan, Riccardo, Reynolds, Jack, and Fernandez, Anthony
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Current evidence suggests that the efficacy of psychedelic therapy depends, in part, on the character of psychedelic experiences themselves. One pronounced aspect of psychedelic experiences is alterations to the experience of time, including reports of timelessness or transcending time. However, how we should interpret such reports remains unclear, and this lack of clarity has philosophical and clinical implications. For instance, “true” timelessness may be considered antithetical to having any experience at all, and descriptions of experiences involving “timelessness” are known to be diverse and of varying clinical significance. In this article, we utilize a phenomenological approach to the study of temporality to highlight ambiguities in current constructs used to assess psychedelic experiences. In doing so, we advance some preliminary phenomenological accounts of psychedelic therapy’s mechanisms of action, such as psychedelic temporality acting as a kind of counterpoint for depressive temporality. We conclude by outlining how a dedicated phenomenological research program can provide a nuanced map of psychedelic temporality, guiding future research in a manner that addresses both philosophical and clinical ambiguities. [ABSTRACT FROM AUTHOR]
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- 2024
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23. Psychological Characteristics of Fathers of People With Bulimia Nervosa: A Systematic Review.
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Akkese, M. N., Keeler, J. L., Teh, J. Y., Treasure, J., and Himmerich, H.
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ABSTRACT Objective Method Results Discussion Bulimia nervosa (BN) is a highly prevalent psychiatric disorder that has negative effects on the physical and psychological health of sufferers. Father‐specific factors have been understudied in the context of BN. This systematic review aims to understand the psychosocial and psychopathological features of fathers of people with BN and their associations with the offspring's outcomes.A literature search on APA PsycINFO, ISI Web of Science, PubMed, Google Scholar, ResearchGate, and Open Science Framework yielded 2421 studies. These papers were independently evaluated based on the eligibility criteria. 29 studies were included in this review. The Joanna Briggs Institute Critical Appraisal Tools were used for the assessment of the methodological quality of the eligible studies.Across studies, no significant differences were found in perceptual body‐size distortion, self‐ideal discrepancy, eating‐/weight‐/body‐related attitudes, several personality and ED traits, and general psychological functioning between fathers of the BN group and those of the comparison groups. However, significant differences were found in certain psychological aspects (e.g., impulse regulation) and ED‐associated features (e.g., body dissatisfaction). Finally, significant relationships were found between the fathers' food attitudes, muscularity ratings, personality traits, and substance abuse and their offspring's risk of developing BN, greater body dissatisfaction, ED symptoms, and poor end‐of‐treatment outcome.Although the existing literature does not seem to strongly suggest a particular paternal factor pertaining to BN, several father‐specific variables may be associated with the offspring's BN symptomatology and related characteristics. Further research is necessary to clearly understand paternal features in the context of BN. [ABSTRACT FROM AUTHOR]
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- 2024
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24. Long-term psychopathology rates of children and adolescents and associated factors in the worst-sticken area of 2023 Kahramanmaras earthquake.
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Eroglu, Mehtap and Yaksı, Nese
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SLEEP interruptions , *SLEEP , *EARTHQUAKES , *SOCIAL support , *PSYCHOLOGICAL factors , *POST-traumatic stress disorder , *CHILD psychopathology - Abstract
AbstractIntroductionMethodResultsDiscussionEarthquakes are natural disasters that can have significant psychological impacts on individuals, particularly children. While physical injuries are often the immediate focus following an earthquake, the psychological effects can be long-lasting and profound. Understanding the psychiatric effects of traumatic experiences in children following earthquakes is crucial for developing effective interventions and support systems.One hundred fifty three children and adolescents who experienced the earthquake were evaluated in the first year of the earthquake. Depression, anxiety, and post-traumatic stress disorder (PTSD) symptoms were measured using standardized assessment tools. Factors that may be related to psychopathology, such as sleep disturbance, the extent of trauma, and where one lived after the earthquake, were also evaluated. The anxiety, depression and stress levels of the mother and father separately and their relationship with the child’s psychopathology were evaluated.The frequency of depression risk among participants was found to be 24.8%, while the frequency of anxiety risk was 62.8%. The frequency of PTSD risk was 97.4%. Children who migrated to another province after the earthquake had higher scale scores. Parental depression anxiety stress level was positively correlated with children’s scale scores. Disruption in sleep patterns increased the risk of depression by 2.38 times. Experiencing the loss of friends in the earthquake increased PTSD score by 6.27.The findings of this study highlight the importance of addressing the psychiatric needs of children following earthquakes. Psychosocial support and access to appropriate treatment should be prioritized to mitigate the long-term psychological effects of traumatic experiences in children. [ABSTRACT FROM AUTHOR]
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- 2024
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25. Can a warm and supportive adult protect against mental health problems amongst children with experience of adversity? A twin‐differences study.
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Stock, Sarah E., Lacey, Rebecca E., Arseneault, Louise, Caspi, Avshalom, Crush, Eloise, Danese, Andrea, Latham, Rachel M., Moffitt, Terrie E., Newbury, Joanne B., Schaefer, Jonathan D., Fisher, Helen L., and Baldwin, Jessie R.
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MENTAL illness , *ADVERSE childhood experiences , *CAUSAL inference , *ENVIRONMENTAL risk , *PATHOLOGICAL psychology - Abstract
Background Methods Results Conclusions Adverse childhood experiences (ACEs) are associated with mental health problems, but many children who experience ACEs do not develop such difficulties. A warm and supportive adult presence in childhood is associated with a lower likelihood of developing mental health problems after exposure to ACEs. However, it is unclear whether this association is causal, as previous research has not accounted for genetic and environmental confounding.We used the twin‐difference design to strengthen causal inference about whether a warm and supportive adult presence protects children exposed to ACEs from mental health problems. Participants were from the Environmental Risk (E‐Risk) Longitudinal Twin Study, a UK population‐representative birth cohort of 2,232 same‐sex twins. ACEs were measured prospectively from ages 5 to 12. Maternal warmth was assessed at ages 5 and 10 through maternal speech samples. Adult support was assessed through child reports at age 12. Mental health problems were assessed through interviews at age 12 with parents and teachers and participants at age 18.Among children exposed to ACEs, those who experienced greater maternal warmth and adult support had lower levels of mental health problems at ages 12 and 18. In monozygotic twin‐difference analyses, the protective effects of maternal warmth and adult support on mental health were attenuated by 70% for maternal warmth and 81% for adult support, compared to phenotypic analyses. Twins who experienced greater maternal warmth and adult support had minimal or no difference in mental health compared to their co‐twins, concordant for ACE exposure.The apparent protective effect of a warm, supportive adult against mental health problems following ACEs is largely explained by genetic and environmental confounding. This suggests that interventions which boost maternal warmth and adult support should be supplemented by components addressing wider family environments and heritable vulnerabilities in children exposed to adversity, to improve mental health. [ABSTRACT FROM AUTHOR]
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- 2024
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26. Depression and associated factors among patients with type 2 diabetic mellitus in Ethiopia: a cross sectional study.
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Dukato, Amanuel, Beyamo, Abera, Habte Hailegebireal, Aklilu, Teklehaimanot, Wegayehu Zeneb, Ayfokru, Abatwoy, Alemnew, Metages, Birhanu Abate, Daniel, Abemie, Worku, Mengistu, Bethlehem Taye, Ayehu Dessie, Yihenew, Mengstie, Leweyehu Alemaw, and Girma, Bekahegn
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MENTAL health services ,MEDICAL personnel ,GLYCEMIC control ,LOGISTIC regression analysis ,PEOPLE with diabetes - Abstract
Background: Depression is a significant public health concern in both developed and developing countries. The burden of depression is particularly high among patients with chronic illnesses in developing countries, creating a dual challenge for both patients and the community. However, depression goes undiagnosed in 50%-75% of patients with chronic conditions such as diabetes mellitus. Additionally, there is limited information about the prevalence of depression among diabetic patients in Ethiopia. Therefore, this study aimed to assess the prevalence and associated factors of depression among type 2 diabetic patients in Ethiopia. Method: An institution-based cross-sectional study was conducted on 376 randomly selected type 2 diabetic patients. Data were collected through face-to-face interviews and from patients' follow-up records. The data were entered into EpiData version 4.6 and analyzed using STATA 14. Bivariable and multivariate logistic regression analyses were employed to identify associated factors. Variables with a p-value of less than 0.25 in the bivariable analysis were selected for multivariate logistic regression. Model fitness was assessed using Hosmer-Lemeshow's test, and associations were reported using adjusted odds ratios with 95% confidence intervals Results: In this study, the prevalence of depression among type 2 diabetic patients was found to be 69.72% (95% CI: 64.75, 74.27). Three factors were significantly associated with depression in these patients: the duration of diabetes mellitus since diagnosis [AOR: 1.17; 95% CI (1.02, 1.34)], glycaemic control [AOR: 1.8; 95% CI (1.09, 3.01)] and cigarette smoking [AOR: 2.18; 95% CI (1.07, 4.46)]. Conclusion: The prevalence of depression among type 2 diabetic patients was high. The Federal Ministry of Health, stakeholders, and the Ethiopian Diabetes Association should collaborate to reduce this burden. Mental health assessment and treatment should be integrated into chronic care follow-up services. Additionally, healthcare providers should closely monitor and counsel patients who smoke and those with poor glycemic control. [ABSTRACT FROM AUTHOR]
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- 2024
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27. Trends in medically serious suicide attempts before and after COVID-19: a four-year retrospective analysis (2018–2022).
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Gonzalez, Anna Beneria, Marte, Luis, Quesada-Franco, Marta, García-González, Sara, Restoy, Damià, Pérez-Galbarro, Citlalli, Santesteban-Echarri, Olga, Ramos, Rosa, Ramos-Quiroga, Josep Antoni, and Braquehais, María Dolores
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COVID-19 pandemic , *ATTEMPTED suicide , *SUICIDE risk factors , *INTENSIVE care units , *PUBLIC health - Abstract
Background: Suicide has become a first-order public health concern after the negative impact of COVID-19 on the general population's mental health. Several studies have analyzed the trends in suicide attempts (SA) before and after the onset of the pandemic, but few studies focus on the impact of the pandemic on medically serious suicide attempts (MSSA). Methods: Participants were 385 hospitalized individuals ≥ 16 years old who made MSSA identified retrospectively through a review of e-medical records between 2018 and 2022 ("pre-COVID-19" and "COVID" periods). The two groups were compared on sociodemographic and clinical variables using Chi-square or Exact Fisher's tests for categorical variables and a Mann-Whitney test for continuous variables. To study the variation in MSSA over time, MSSA were aggregated monthly. Joinpoint regression analyses were used to assess time trends. Results: A sample of 161 MSSA patients, 80 women and 81 men, were selected from 385 admissions after a suicide attempt (SA) in the four years (n = 160 pre-COVID period vs. n = 225 COVID period) (OR = 1.41; CI 95% = 1.0003–1.7223, p < 0.001). Sixty-eight patients with MSSA were admitted during the first period, and 93 during the COVID period (OR = 1.4 ; CI 95% = 1–1.9 ; p < 0.05). MSSA patients were more likely to be admitted to an intensive care unit during the COVID period than during the pre-COVID period (OR = 3.5; CI 95% = 1.7–6.9; p < 0.001). Conclusions: This study highlights the need for research on suicide risk during and after crisis periods, such as the COVID-19 pandemic. It provides valuable knowledge on the incidence of SA needing hospitalization, MSSA, and highly severe MSSA for four years before and after the pandemic onset. [ABSTRACT FROM AUTHOR]
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- 2024
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28. Can neurocognitive performance account for dimensional paranoid ideation?
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Wong, Andrea, Baughman, Frank D., Mullan, Barbara A., Heslop, Karen, Dauer, Evan, and Haywood, Darren
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PATHOLOGICAL psychology , *SHORT-term memory , *INFORMATION processing , *MENTAL health , *EVERYDAY life , *PARANOIA - Abstract
ObjectiveMethodsResultsConclusionsParanoid ideation underlies numerous psychological disorders and has debilitating effects on daily life. Deficits in neurocognition are highlighted as a contributing factor to paranoid-related disorders, but the impact on the symptom-level experience of paranoid ideation is unclear. This study aimed to employ a dimensional approach to understand the association between neurocognition and the severity and presence of paranoid ideation.400 participants, representative of the general population of the USA, completed an online questionnaire consisting of the Brief Symptom Inventory-53, and demographic and clinical questions. The participants then completed four computerised neurocognitive tasks measuring working memory, shifting, inhibition, and speed of processing.Speed of processing accounted for unique variance in the severity of paranoid ideation with a small effect size, after controlling for covariates. Working memory, shifting, and inhibition could not uniquely or collectively, account for paranoid ideation. Neurocognitive performance could not distinguish between individuals with and without paranoid ideation experiences.This research supports the body of literature that speed of information processing may be a key feature of paranoid ideation. Future research should employ non-linear dynamic methods to better understand the potential interactions between neurocognitive components and how this may relate to paranoid ideation. [ABSTRACT FROM AUTHOR]
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- 2024
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29. Early maladaptive schemas in adolescents with attention deficit hyperactivity disorder.
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Sireli, Ozlem, Colak, Mehmet, Demirci, Tugce Hilda, Savascihabes, Ayse Ece, and Oz Cinar, Hatice
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ATTENTION-deficit hyperactivity disorder ,AGE groups ,INCOME ,AFFECTIVE disorders ,REGRESSION analysis - Abstract
Introduction: Current evidence suggests that early maladaptive schemas are affected in attention deficit hyperactivity disorder (ADHD). Most of the studies on the subject have been conducted with adults, but the number of studies conducted with adolescents with ADHD is quite limited. The aim of this study was to evaluate early maladaptive schemas in adolescents diagnosed with ADHD. Methods: The study included 66 patients diagnosed with ADHD and 70 healthy adolescents who were similar to the case group in terms of age and gender. Clinical evaluation of the case and control groups were performed with "The Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version, DSM-5 November 2016-Turkish Adaptation (K-SADS-PL-DSM-5-T)". "Conners-Wells Adolescent Self-Report Scale - Revised Short Form (CASS-RS)" and "Set of Early Maladaptive Schema Questionnaires for Children and Adolescents between the ages of 10-16" were administered to all participants. Results: It was determined that the schema scores of "dependence/incompetence", "vulnerability to harm or illness", "entitlement/grandiosity", "insufficient self-control", "subjugation" were significantly higher in the ADHD group than in the control group. A negative, significant relationship was found between age and "enmeshment/undeveloped self", "entitlement/grandiosity" and "insufficient self-control" schema scores. There was no significant difference between schema scores in terms of gender in the ADHD group. Additionally, no significant relationship was found between the education level of the parents, family income levels and schema scores. A significant positive relationship was found between the CASS-RS scores and all schema scores. As a result of the regression analysis, it was determined that CASS-RS scores positively predicted all schema scores, while the age variable negatively predicted only the schema scores of "enmeshment/undeveloped self". Discussion: Results of this study showed that there were significant differences in adolescents in the ADHD group compared to the control group in terms of early maladaptive schemas, and that ADHD symptom levels was associated with early maladaptive schemas. [ABSTRACT FROM AUTHOR]
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- 2024
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30. Differential effects of trait-like emotion regulation use and situational emotion regulation ability across the affective and anxiety disorders spectrum: a transdiagnostic examination.
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Adolph, Dirk and Margraf, Jürgen
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COGNITIVE therapy , *AFFECTIVE forecasting (Psychology) , *PATHOLOGICAL psychology , *EMOTION regulation , *AFFECTIVE disorders - Abstract
Here, we investigated the association of different emotion regulation (ER) indices with symptom severity across a large transdiagnostic sample of patients with emotional disorders (cross-sectional approach) and the predictive validity these ER indices have for the outcome of routine care CBT (longitudinal approach). We assessed the trait-like use of adaptive (reappraisal) and maladaptive (suppression, externalizing behaviors) ER strategies via questionnaire as well as the situational ability to regulate emotions with an experimental ER paradigm. Psychopathology was assessed dimensionally using the depression, anxiety, and stress scale. Cross-sectionally symptom severity was predicted by less trait-like use of adaptive and more trait-like use of maladaptive ER strategies, but no associations were found for situational ER ability. This association was more pronounced for depression and stress symptoms rather than anxiety symptoms. In a striking dissociation, the longitudinal analyses revealed the reverse picture: Better situational ER ability, but not trait-like use of ER strategies was associated with less symptom severity after the CBT treatment. Our data argues in favor of a distinction between trait-like and situational ER abilities in individuals with emotional disorders, highlighting challenges in applying adaptive ER strategies in daily life despite demonstrating intact ER skills in experimental settings. Our findings also inform transdiagnostic models of psychopathology and suggest that distress/depression rather than anxiety symptomatology to be driving forces for the occurrence of ER deficits across the depression/anxiety disorders spectrum. [ABSTRACT FROM AUTHOR]
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- 2024
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31. Is cannabis associated with more than just driving impairment? An investigation into the psychological dysfunctioning and driving behaviours of active cannabis users.
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Love, Steven, Unger, Petra, Rowland, Bevan, and Armstrong, Kerry
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• Chronic cannabis use patterns were associated with psychological dysfunction. • Chronic cannabis use patterns were linked with emotion-directed driving styles. • Dependent users were at greater risk of psychological dysfunction and risky driving. • Other substance use and the tendency to drive under the influence were controlled for. • Cannabis use indirectly influenced risky driving via effects on self-regulatory deficits. Research has suggested that problematic cannabis use is associated with self-regulatory impairments, psychopathology, and the tendency to engage in risk taking behaviours. However, no research has applied the combined dynamics of these factors to the topic of risky driving behaviour specifically. This study investigated whether specific cannabis use patterns (i.e., use onset, duration, frequency, and quantity) and likely dependence influenced driving styles, via their effects towards emotional dysregulation and psychopathology (i.e., anxiety, depression, anger), among an online sample of active Australian cannabis users (N = 200). Group comparisons showed that likely dependent cannabis users reported significantly greater difficulties regulating their emotions, greater incidence of psychopathological symptoms (i.e., anxiety, depression, and anger), and more frequent engagement in risky driving styles (i.e., anxious driving, aggressive driving, dissociative driving, and reckless driving), compared to non-dependent cannabis users. Examination of bivariate correlations demonstrated significant and positive associations between specific cannabis use patterns, emotional regulation difficulties, psychopathology, and risky driving styles. Structural equation modelling highlighted that cannabis use patterns indirectly predicted participants self-reported engagement in risky driving styles via their effects towards self-regulatory difficulties and psychopathology. The findings of this study have highlighted driving related risks associated with cannabis use, outside of typical acute-related impairments. In addition, the study has emphasised the importance of psychological dysfunctioning in the engagement of both substance use and risky driving styles. Understanding this in combination is important for future interventions targeting aberrant driving behaviours. [ABSTRACT FROM AUTHOR]
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- 2024
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32. Psychopathology and the Validity of Gastrointestinal Symptom Reporting as Revealed Through Cluster Analyses of MMPI-2-RF Results.
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Lang, Paris A., Thomas, Linda, and Lidbury, Brett A.
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PERSONALITY assessment , *HEALTH impact assessment , *PATHOLOGICAL psychology , *PSYCHOLOGICAL factors , *CLUSTER analysis (Statistics) - Abstract
Background: Psychological state, self-reported gut symptoms, and somatic complaints are recognized relationships that can impact health assessment and subsequent treatment. Aim: To investigate the impact of psychological state and personality on symptom self-reporting and somatization. Methods: Sixty-two (62) participants from the Hunter region of NSW (Australia) undertook a survey of health and lifestyle along with an MMPI-2-RF assessment of personality, psychopathology, and test-taking attitude. Participants also completed the Rome Criteria to assess functional gastrointestinal disorders (FGIDs). To assist the interpretation of MMPI-2-RF results, clustering was applied to identify similar responses and sub-cohort profiles of reporting. Results: Cluster analysis revealed four sub-cohorts, stratified by psychopathology, gut-related symptoms, and the validity of self-reported somatic complaints. Sample clustering identified one sub-cohort defined by high rates of negative affectivity and suicidal ideation. Apart from these differences, clusters were uniform for age, sex, smoking, mental health diagnoses, as well as for gut-related conditions. Conclusion: Results provide further evidence of the interaction of the gut–brain axis and its relationship to serious mental health conditions. It also points to the need to assess the veracity of self-reported symptomatology that may be both pathognomonic for psychopathology but might also be a consequence of gut dysbiosis. Clustering assisted these investigations by defining distinct sub-cohorts based on participant MMPI-2-RF responses. [ABSTRACT FROM AUTHOR]
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- 2024
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33. Verschwörungstheorien, gesellschaftliche Polarisierung und Krisen.
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Fritze, Jürgen
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CONSPIRACY theories , *POLARIZATION (Social sciences) , *COGNITIVE ability , *SOCIAL contract , *SOCIOLOGICAL research - Abstract
Objective: Social media facilitate the distribution of conspiracy theories. It is uncertain whether indeed the number of myths and also the number of those who appropriate myths has increased. Conspiracy theories have so far essentially been the subject of sociological and psychosociological research showing a general disposition to become infected irrespective of the topic of a myth. Are there specific psychopathological risk factors for becoming infected by conspiracy myths? Are there effective therapeutic or preventive measures? Methods: A systematic search was carried out in PubMed using the query "conspir*[title] AND review" followed by manual selection and appraisal only of publications addressing conspiracy theories in general, i.e. not limited to specific myths, with a focus on systematic reviews and meta-analyses. Moreover, the publications identified were manually screened for further meta-analyses. Results: The search resulted in 166 hits. The available evidence is essentially based on studies using questionnaires, which can clarify only associations but not causalities. The evidence suggests that the strongest correlates of conspiratorial ideation pertain to low cognitive abilities, nonanalytic style of thought resulting in reduced balancing of probabilities before deciding, feelings of loss of control, paranoia, schizotypy and the dark triad (narcissism, Machiavellianism, authoritarianism). Conclusion: Specific psychological characteristics are risk factors for conspiratorial ideation. Current research approaches are unsuitable to clarify whether psychiatric disorders are overrepresented. Sociodemographic risk factors include male gender, low level of education, low income, social isolation and are non-specific. Group processes promote, again presumably nonspecifically, conspiracy theories thus contributing to social polarization. The genetic basis and neurobiological mechanisms are unknown. Conspiracy theories were and are used as an instrument of political contention. The enlightened democratic social contract requires free, unbiased thinking. Consequently, the risk factors identified so far facilitate conspiratorial ideation and question the very fundaments of the social contract by impairing unbiased evaluation and decision making. Therefore, prevention is warranted.. [ABSTRACT FROM AUTHOR]
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- 2024
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34. The Role of Gender and Culture in Psychopathic Leadership From a Southeast Asian Context.
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Ilac, Emerald Jay D. and Mactal, Ma. Tonirose D.
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ANTISOCIAL personality disorders , *PATHOLOGICAL psychology , *TOXICITY testing , *JOB satisfaction , *PERSONALITY , *LEADERSHIP - Abstract
The prior research has explored the impact of psychopathic personality on leadership and follower behavior. Following Dunham and Pierce's (1989) leadership continuum model to evaluate the impact of damaging leadership, this study investigated the impact of leaders' psychopathic personality and its resultant demonstration of toxic behaviors on followers' job satisfaction. Moreover, it extended the limited research on gender as a moderating variable between psychopathic personality and leadership toxicity by testing a moderated mediation model. A quantitative survey of 319 followers from different organizations was conducted using an online platform. Findings revealed significant relationship between the leaders' psychopathic personality and their demonstration of toxic behaviors. Also, leaders' toxic behaviors were found to mediate between personality and job satisfaction. Furthermore, gender was found as a significant moderator between personality and toxic leadership behavior. However, in contrast with the studies in the Global North, leaders' psychopathic personality and their toxic leadership behaviors were perceived as stronger among females, regardless of the industry they worked in. These results open the discussion on the impact of culture and gender on leader psychopathology and toxicity. [ABSTRACT FROM AUTHOR]
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- 2024
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35. Prospective Associations Between Early Adolescent Reward Functioning and Later Dimensions of Psychopathology.
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Mattoni, Matthew, Pegg, Samantha, Kujawa, Autumn, Klein, Daniel N., and Olino, Thomas M.
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PATHOLOGICAL psychology , *MULTIPLE comparisons (Statistics) , *INDIVIDUAL differences , *ADOLESCENCE , *TEENAGERS - Abstract
Individual differences in reward functioning have been associated with numerous disorders in adolescence. Given relations with multiple forms of psychopathology, it is unclear whether these associations are disorder specific or reflective of shared variance across multiple disorders. In a sample of adolescents (N = 418), we examined associations between neural and self-reported indices of early reward functioning (age 12) with different levels of a hierarchical psychopathology model assessed later in adolescence (age 18). We examined whether prospective relationships between reward functioning are specific to individual disorders or better explained by transdiagnostic dimensions. We found modest results for prospective associations between reward indices and different dimensions of psychopathology, with most significant associations not surviving correction for multiple comparisons. We discuss the benefits and limitations of the modeling approach used to examine dimension-specific associations that future work can build on. Overall, more work is needed to better understand how reward functioning is specifically associated with different forms of and hierarchical levels of psychopathology. General Scientific Summary: Adolescent reward functioning is associated with numerous forms of psychopathology, leaving uncertainty whether the relationships are disorder specific or better explained by transdiagnostic factors. Here, we examined prospective relationships between early adolescent reward functioning and a psychopathology hierarchy measured later in adolescence. We found modest results and discuss implications that future work can build on. [ABSTRACT FROM AUTHOR]
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- 2024
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36. Shared Principles for Disentangling Heterogeneity in Neuroscience and Psychopathology.
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Kraus, Brian and Gratton, Caterina
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PATHOLOGICAL psychology , *CLINICAL neurosciences , *BRAIN anatomy , *INDIVIDUAL differences , *MENTAL illness - Abstract
A primary goal of clinical neuroscience is to identify associations between individual differences in psychopathology and the brain. However, despite a significant amount of resources invested in this endeavor, few reliable neural correlates of psychopathology have been identified. A common suspect for this lack of success is the significant heterogeneity in symptoms observed in psychiatric disorders. However, this is not the only potential source of heterogeneity, as substantial heterogeneity is also observed in brain structure and function. Thus, for clinical neuroscience to identify reliable neural correlates of psychopathology, it will be necessary to better understand heterogeneity in both psychopathology and the brain. In this commentary, we suggest four shared principles that can help disentangle heterogeneity in both of these domains: (a) the brain and behavior should both be treated as complex measures, (b) a priori assumptions should be viewed with caution unless they can be replicated robustly in individuals, (c) complex models of individual differences require appropriate data to estimate them, and (d) the field would benefit from an increased focus on extensively measuring individuals, such as through the use of personalized models of psychopathology and neuroimaging data. Together, these shared principles can aid in better characterizing—and separating relevant and irrelevant—heterogeneity in measures of psychopathology and neuroimaging. General Scientific Summary: A primary goal of clinical neuroscience is to identify associations between the brain and psychopathology. To accomplish this goal, the field will have to adopt more comprehensive measures that are reliable within individuals, such as personalized models. Otherwise, clinical neuroscience will continue to be plagued by small effect sizes with limited clinical utility. [ABSTRACT FROM AUTHOR]
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- 2024
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37. From Deconstruction to Reconstruction: A Search for Natural Kinds in Developmental Psychopathology.
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Brotman, Melissa A., Haller, Simone P., Pine, Daniel S., and Fox, Nathan A.
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PATHOLOGICAL psychology , *MENTAL illness , *RESEARCH personnel , *MENTAL health , *PSYCHIATRY - Abstract
A "natural kind" is a specific classification that identifies some structure of truth and reality, a delimited entity. Psychiatric disorders are not natural kinds. As one moves from physics and chemistry to biology and medicine, natural kinds degrade, and the boundaries of differentiating phenomena become less clear. Within psychiatry, the categorization of psychopathology has further ontological challenges, especially across development. We suggest that to identify and isolate clinical subgroups, it is critical to integrate external validators in an iterative process, with the goal of linking classification to treatments with maximal clinical benefit. General Scientific Summary: This commentary discusses the how the field of psychiatry conceptualizes and categories disorders. We reiterate that mental health difficulties are complex phenomena. We further suggest that clinical researchers increase attention on categorization based on response to treatments that effectively alleviate symptoms. [ABSTRACT FROM AUTHOR]
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- 2024
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38. Characterization of pain and somatization and its relationship with psychopathology in early onset psychosis.
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van der Heijden, Hanne, Goldman, Maria, Ray, Aliza, Golden, Emma, Petty, Carter R., Deaso, Emma, Hojlo, Margaret, Sethna, Navil, Glahn, David C., Gonzalez-Heydrich, Joseph, and Upadhyay, Jaymin
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PSYCHIATRIC rating scales , *PAIN catastrophizing , *PATHOLOGICAL psychology , *SYMPTOMS , *ANTIPSYCHOTIC agents - Abstract
Early onset psychosis (EOP) frequently presents with a severe clinical phenotype and poor long-term prognosis. Clinical experience suggests that individuals with EOP have abnormal pain and somatosensory processing, yet relative to adult-onset psychosis, pain and somatic sensory processing in EOP have rarely been studied. The history of two characteristic patients is described to illustrate clinical presentations of pain in EOP patients. Furthermore, 31 patients with EOP were studied with self-reported questionnaires informing on pain severity, pain catastrophizing, central sensitization, and somatization. Structured clinical interviews were administered to confirm Diagnostic and Statistical Manual of Mental Disorders-5 EOP diagnosis and the patient's dimensions of psychopathology were measured by the Brief Psychiatric Rating Scale (BPRS). Out of 31 EOP patients, 22 reported distressing pain, where higher pain severity corresponded with greater BPRS total and affectivity and resistance subscale scores. The degree of psychopathology was associated (N = 31; p < 0.05, FDR-corrected) with the magnitude of pain catastrophizing, central sensitization, and somatization. Multivariate analysis revealed relationships (N = 31; p < 0.05, FDR-corrected) between BPRS subscale (negative symptoms and activation) scores with somatization severity. The observed associations occurred independent of antipsychotic medication usage as quantified by chlorpromazine equivalent doses. Pain and somatosensory symptoms could be a frequent cause of distress in patients with EOP and their severity associated with the degree of psychopathology. Future studies should determine if treating pain and somatic symptoms in EOP patients can lead to better control of psychosis as well as improve quality of life. [ABSTRACT FROM AUTHOR]
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- 2024
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39. The same but different too: Depression profiles in young adults without a history of psychiatric treatment identified using Bayesian and partial correlation networks.
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Misiak, Błażej, Rejek, Maksymilian, Bielawski, Tomasz, Błoch, Marta, Samochowiec, Jerzy, Bąba-Kubiś, Agata, Gawęda, Łukasz, and Maciaszek, Julian
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MENTAL depression , *TRANSITION to adulthood , *PSYCHIATRIC treatment , *YOUNG adults , *AFFECTIVE disorders - Abstract
Depression is a heterogenous diagnostic construct; however, dynamic interactions between specific depressive symptoms across their qualitatively different profiles remain largely unknown. The study aimed to recognize the most prevalent profiles of depressive symptoms and assess their dynamics in young adults without a history of psychiatric treatment. Depressive symptoms were recorded using the Patient Health Questionnaire-9 (PHQ-9). The data were assessed for all theoretical and empirical combinations of depressive symptoms in participants with a positive screening for depression. The profiles identified in the majority of participants were analyzed using partial correlation and Bayesian networks. Data from 3583 individuals with a positive screening for depression were analyzed. Out of 382 theoretical profiles, 150 profiles (39.3%) were present in this dataset. The majority of participants (56.8%) showed 4 profiles of depressive symptoms including the profile with all depressive symptoms present, the profile without suicidal ideation, the profile without psychomotor impairment, and the profile without both psychomotor impairment and suicidal ideation. The profiles differed largely in terms of their dynamics and symptoms that are necessary to activate the whole network. The network characteristics within specific profiles did not differ significantly across the level of difficulties attributable to depressive symptoms. Our findings indicate that depression emerging in young adults shows a limited number of symptom profiles. However, dynamics of depressive symptoms differs largely between specific profiles regardless of functional impairment indicating the need to personalize therapeutic approaches. Future studies should further disentangle the heterogeneity of depressive symptoms, e.g., by dissecting the symptoms that are combined together by single PHQ-9 items (i.e., hypersomnia and insomnia; psychomotor agitation and retardation). [ABSTRACT FROM AUTHOR]
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- 2024
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40. Associations between trauma exposure and irritability within the family unit: a network approach.
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Cotter, Grace, Morreale, Kristina, Valdegas, Amanda, Fish, Meghan, Beebe, Rebecca, Grasso, Damion, Stover, Carla, and Tseng, Wan‐Ling
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PARENTS , *EMOTION regulation , *POST-traumatic stress disorder , *CROSS-sectional method , *VIOLENCE , *RESEARCH funding , *ANGER , *QUESTIONNAIRES , *AFFECTIVE disorders , *DESCRIPTIVE statistics , *EMOTIONAL trauma , *BEHAVIOR disorders in children , *RACE , *ODDS ratio , *HISTORICAL trauma , *CONFIDENCE intervals , *DATA analysis software , *ADVERSE childhood experiences , *PATHOLOGICAL psychology , *DISEASE complications , *CHILDREN - Abstract
Background: Pediatric irritability is a pervasive psychiatric symptom, yet its etiology remains elusive. While trauma exposure may contribute to the development of irritability, empirical research is limited. This study examined the prevalence of irritability among trauma‐exposed children, identified factors that differentiate trauma‐exposed children with and without irritability, and employed a network analysis to uncover associations between irritability and trauma exposure in the family unit. Methods: Sample included 676 children (56.3% male, mean age = 9.67 ± 3.7 years) and their parents referred by the Connecticut Department of Children and Families to Fathers for Change – a psychotherapy intervention designed to reduce intimate partner violence (IPV) and child maltreatment. Child's trauma exposure, post‐traumatic stress disorder (PTSD) symptoms, and irritability were assessed pre‐intervention using self‐ and caregiver‐report. Parents self‐reported their childhood and adulthood trauma exposures, PTSD symptoms, irritability, psychopathology, and IPV. Results: Across caregiver‐ and child‐reports, 16%–17% of children exhibited irritability. Irritable children experienced greater trauma exposure, interpersonal violence, emotional abuse, and PTSD severity. They had caregivers, particularly mothers, with greater trauma histories, IPV, and psychopathology. Network analysis revealed 10 nodes directly correlated to child's irritability including child's PTSD severity, parental IPV (specifically psychological violence), and parental psychopathology. Conclusions: Results provide initial empirical evidence that pediatric irritability is linked to trauma exposure, suggesting trauma histories be considered in the diagnosis and treatment of irritability. Interventions addressing caregiver trauma, IPV, and psychopathology may ameliorate pediatric irritability. Future studies could benefit from adopting network approaches with longitudinal or time series data to elucidate causality and points of intervention. [ABSTRACT FROM AUTHOR]
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- 2024
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41. State of the Science in Behavior Therapy: Taking Stock and Looking Forward.
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Comer, Jonathan S.
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BEHAVIOR therapy , *PSYCHOTHERAPY , *COGNITIVE therapy , *LITERATURE reviews ,PSYCHIATRIC research - Abstract
The scope and burdens of mental health challenges in today's world are staggering. Among the available psychological treatment approaches, cognitive and behavioral therapies, and their combinations, have garnered the strongest evidence base. That said, progress has not always been linear and most of the work is still ahead of us. Against this backdrop, Behavior Therapy has launched its State of the Science series—an exciting new journal feature offering a curated set of authoritative reviews of research in major areas of relevance to applied cognitive-behavioral science, written by distinguished scientists in each area and peer-reviewed. The vision for the Behavior Therapy State of the Science series is to launch with an initial set of articles that make up this special journal issue, with continued publication of additional State of the Science articles in future journal issues. The current article launches the State of the Science series, providing a brief summary of progress in cognitive and behavioral practice and related areas, as well as various missteps and harmful legacies that remind us that the state of the science for research focused on mental health and the alleviation of human suffering is always in flux and evolving. The 16 inaugural reviews in this special issue are then introduced one by one. Collectively, these State of the Science reviews take stock of what has been learned across key areas in the field, highlight critical knowledge gaps in need of research, and provide expert guidance for improving the effectiveness and reach of care, particularly for marginalized and underserved populations. [ABSTRACT FROM AUTHOR]
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- 2024
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42. The Transdiagnostic Global Impression - Psychopathology scale (TGI-P): Initial development of a novel transdiagnostic tool for assessing, tracking, and visualising psychiatric symptom severity in everyday practice.
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Correll, Christoph U., Dombi, Zsófia B., Barabássy, Ágota, Németh, György, Brevig, Thomas, and McIntyre, Roger S.
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PATHOLOGICAL psychology , *PATIENTS' attitudes , *MENTAL depression , *SATISFACTION , *MENTAL illness - Abstract
• The Transdiagnostic Global Impression – Psychopathology scale (TGI-P) assesses and visualizes severity across 10 transdiagnostic psychiatric symptom domains. • The TGI-P is based on the Clinical Global Impression-Severity scale, rating each symptom domain from 1 (normal) to 7 (extreme severity). • As part of the scale development process, 36 psychiatrists were surveyed and 70 % of them expressed their willingness to use the TGI-P in everyday practice due to its simplicity and perceived utility to provide a comprehensive yet fast transdiagnostic assessment of 10 relevant symptom domains. Lacking biomarkers in psychiatry calls for a valid and reliable assessment of psychopathology across mental disorders that is easy to use, bridges research and clinical care, and that can capture clinician and patient perspectives. Herein we propose, a novel, brief, transdiagnostic tool to assess and visualize symptom severity in different psychiatric disorders. The Transdiagnostic Global Impression – Psychopathology scale (TGI-P) is based on the Clinical Global Impression – Severity scale (CGI-S), which was originally designed to measure global illness severity in one score. The TGI-P covers 10 transdiagnostic symptom domains and similar to the CGI-S, it is rated on a 7-point Likert-scale from 1 (normal) to 7 (extreme). These ten domains include positive symptoms, negative symptoms, manic symptoms, depressive symptoms, addiction symptoms, cognitive symptoms, anxiety symptoms, sleep symptoms, hostility symptoms, and self-harm symptoms. The results are visually presented, thus simplifying the monitoring of symptoms, and facilitating discussion with patients and caregivers. As part of the development process, the TGI-P was surveyed among 36 psychiatrists from 3 countries. Importantly, over 80 % of them was "very positive" or "positive" about the concept of the tool, and most of them (70 %) reported willingness to use it in their everyday practice. Further psychometric development and testing of the TGI-P is underway alongside future TGI scales covering adverse events, functioning and satisfaction. [ABSTRACT FROM AUTHOR]
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- 2024
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43. Homicidal Ideation in a Sample of Capital Murderers: Prevalence, Morbidity, and Associations With Homicide Offending.
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Burgason, Kyle, Caudill, Jon, DeLisi, Matt, and Trulson, Chad R.
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HOMICIDE , *MURDERERS , *CRIMINOLOGY , *PRISONERS - Abstract
Homicidal ideation is an important, but understudied construct in criminological research. Unfortunately, previous investigations into homicidal ideation are limited by reliance on small convenience samples, larger correctional samples with limited access to the most serious and violent criminal offenders, and single-item measures of the central construct. The current study improves and extends existing research by examining the link between three unique measures of homicidal ideation spanning its frequency, chronicity, and severity on murder and attempted murder among an enriched sample of death-sentenced prisoners in California. Many individuals in these data have extensive criminal careers and multiple homicide offenses. Homicidal ideation frequency and severity were significantly associated with both murder and attempted murder convictions, homicidal chronicity had null effects. Implications for research and practice are discussed. [ABSTRACT FROM AUTHOR]
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- 2024
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44. The General Psychopathology 'p' Factor in Adolescence: Multi-Informant Assessment and Computerized Adaptive Testing.
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Jones, Jason D., Boyd, Rhonda C., Sandro, Akira Di, Calkins, Monica E., Los Reyes, Andres De, Barzilay, Ran, Young, Jami F., Benton, Tami D., Gur, Ruben C., Moore, Tyler M., and Gur, Raquel E.
- Abstract
Accumulating evidence supports the presence of a general psychopathology dimension, the p factor ('p'). Despite growing interest in the p factor, questions remain about how p is assessed. Although multi-informant assessment of psychopathology is commonplace in clinical research and practice with children and adolescents, almost no research has taken a multi-informant approach to studying youth p or has examined the degree of concordance between parent and youth reports. Further, estimating p requires assessment of a large number of symptoms, resulting in high reporter burden that may not be feasible in many clinical and research settings. In the present study, we used bifactor multidimensional item response theory models to estimate parent- and adolescent-reported p in a large community sample of youth (11–17 years) and parents (N = 5,060 dyads). We examined agreement between parent and youth p scores and associations with assessor-rated youth global functioning. We also applied computerized adaptive testing (CAT) simulations to parent and youth reports to determine whether adaptive testing substantially alters agreement on p or associations with youth global functioning. Parent-youth agreement on p was moderate (r =.44) and both reports were negatively associated with youth global functioning. Notably, 7 out of 10 of the highest loading items were common across reporters. CAT reduced the average number of items administered by 57%. Agreement between CAT-derived p scores was similar to the full form (r =.40) and CAT scores were negatively correlated with youth functioning. These novel results highlight the promise and potential clinical utility of a multi-informant p factor approach. [ABSTRACT FROM AUTHOR]
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- 2024
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45. Sağlık Çalışanlarının Ruh Sağlığı, İntihar Düşüncesi, Mobbinge Maruziyet ve İş Doyumu: Bir İkinci Basamak Hastane Örneklemi.
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İnaltekin, Ali and Yağcı, İbrahim
- Abstract
Copyright of Osmangazi Journal of Medicine / Osmangazi Tip Dergisi is the property of Eskisehir Osmangazi University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2024
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46. Menschenkunde in strukturdynamischer Absicht: Werner Janzarik im Spiegel Friedrich Nietzsches.
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Bormuth, Matthias
- Abstract
Copyright of Forensische Psychiatrie, Psychologie, Kriminologie is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2024
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47. Practitioners' perspectives on the challenges of dealing with the interaction between mental illness and violent extremism in Countering Violent Extremism (CVE).
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Schulten, Norah
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MENTAL health services ,PATHOLOGICAL psychology ,PEOPLE with mental illness ,MENTAL illness ,MENTAL health - Abstract
While mental health frameworks are increasingly accepted in Countering Violent Extremism (CVE) policies, little is known about practitioners' experiences when individuals are mentally ill. This paper discusses how mental health clinicians review interactions between psychopathology and violent extremism, and which challenges Dutch practitioners face in decision-making processes around including severely mentally ill people in CVE individual case management approaches. Inclusion means that people are identified as (potential) violent extremists, which justifies CVE interventions on top of regular mental health care. Semi-structured interviews were conducted with 12 international mental health clinicians and 13 Dutch CVE practitioners. Data was analysed with qualitative thematic analysis. Results show that professionals usually view the risk of extremist violence, and not psychopathology, as the decisive factor for inclusion, unless (forensic) mental health clinicians advise otherwise. Nevertheless, some practitioners can experience challenges around making dichotomous choices about including mentally ill persons. Some expressed concerns about illegitimately labelling certain people as 'radicalised' when they suffer from severe mental illnesses (e.g. psychosis). CVE cases with mental illnesses are, however, characterised by heterogeneity, non-dichotomy and missing information. False negatives and false positives concerning uptake in pre-emptive CVE policies can have detrimental individual and societal effects. Future research suggestions are provided. [ABSTRACT FROM AUTHOR]
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- 2024
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48. Identifying cognitive, affective, and developmental mechanisms linking threat and deprivation with adolescent psychopathology.
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Sadikova, Ekaterina, Weissman, David G., Rosen, Maya L., Robinson, Elise, Lengua, Liliana J., Sheridan, Margaret A., Tiemeier, Henning, and McLaughlin, Katie A.
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REWARD (Psychology) , *INTERNALIZING behavior , *PATHOLOGICAL psychology , *EXTERNALIZING behavior , *THEORY of mind - Abstract
Background Methods Results Conclusions The mechanisms linking early‐life adversity with psychopathology over the life‐course are complex. In this prospective study, we collectively examined cognitive, affective, and developmental mediators previously found to individually link childhood threat and deprivation experiences to adolescent psychopathology to identify the most potent mechanisms.Data came from a community sample of 227 children (mean child age 11.5 ± 0.5 years, 48.5% female) from the Seattle metro area with recruitment designed to reflect diversity in family income. Candidate mechanisms included self‐rated pubertal development and task‐measured attention bias to threat, emotion regulation, theory of mind, fear learning, inhibitory control, language ability, reasoning, and reward sensitivity. Using a high‐dimensional mediation approach, we determined which mediating pathways linking threat and deprivation to psychopathology persisted after controlling for all candidate mechanisms associated with psychopathology. Models additionally controlled for the child's age, sex, early‐childhood emotional and behavioral symptoms, poverty, and maternal depression.Blunted reward sensitivity mediated the prospective relationship between threat and internalizing psychopathology, explaining 17.25% (95% CI 1.08%, 69.96%) of this association. Advanced pubertal development was associated with increases in internalizing and externalizing symptoms (standardized associations of 0.16 (95% CI 0.03, 0.29) and 0.17 (95% CI 0.05, 0.29), respectively), but not with adversity. Although deprivation was strongly related to psychopathology, no mechanisms were empirically identified.In a well‐characterized community sample, we isolated reward sensitivity as a robust mediator of the prospective association between early‐life threat and adolescent internalizing psychopathology. Interventions aimed at bolstering reward sensitivity may mitigate the impact of early‐life threat experiences on internalizing problems. [ABSTRACT FROM AUTHOR]
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- 2024
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49. Psychopathology, psychopathy, body management, and undoing in youthful parricide offenders.
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Myers, Wade, Chan, Heng Choon (Oliver), Safarik, Mark, Khalid, Zain, and Vo, Eleanor
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ABUSED children , *PATHOLOGICAL psychology , *PSYCHIATRIC diagnosis , *CRIME scenes , *PSYCHOPATHY , *JUVENILE offenders - Abstract
This study of 21 youthful parricide offenders (YPOs) ages 11–21 examined the relationship between psychopathology, level of psychopathy, and crime scene behaviors, particularly two forms of “body management”: (1) “body movement” and (2) “body alteration.” Undoing, a form of body alteration reflecting psychological rather than practical needs, for example, to lessen guilt or symbolically reverse the killing, was present in one‐third of the sample. The sample shared common characteristics with juvenile parricide offenders overall in that most of them killed one parent, were victims of chronic child abuse, had one or more psychiatric diagnoses (PTSD was most prevalent), used a firearm, and committed the killings at the family home. Unexpectedly, YPOs who were child abuse victims were not more likely to engage in undoing behaviors than non‐abused youth, and over half of the youth with undoing behaviors had elevated psychopathy levels. Three‐quarters of youth who moved victim bodies following the murders had elevated psychopathy levels. Similarly, all three youth who transported bodies away from the crime scene had elevated psychopathy levels and conduct disorder. None of the youth with psychotic symptoms engaged in undoing behaviors, altered victim bodies, moved bodies either within or away from the home, or had an elevated degree of psychopathy; they also most often killed using bladed weapons, whereas the nonpsychotic youth usually used firearms. Studies examining the influence of mental illness and psychopathy level on parricidal behaviors by youth are scarce, and to our knowledge this is the largest study to date investigating this area. [ABSTRACT FROM AUTHOR]
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- 2024
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50. Highfield imaging of the subgenual anterior cingulate cortex in uni- and bipolar depression.
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Buchholz, Frederik, Meffert, Martin, Bazin, Pierre-Louis, Trampel, Robert, Turner, Robert, and Schönknecht, Peter
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GRAY matter (Nerve tissue) ,LIMBIC system ,WHITE matter (Nerve tissue) ,MAGNETIC resonance imaging ,MENTAL depression - Abstract
Background: The subgenual Anterior Cingulate Cortex (sgACC), as a part of the Anterior Cingulate Cortex and the limbic system plays a crucial role in mood regulation. Previous structural and functional brain imaging studies of the sgACC have revealed alterations of Gray Matter (GM) volumes and Blood Oxygenation Level Dependent signals (BOLD) in patients with Major Depressive Disorder (MDD) and Bipolar Disorder (BD), suggesting potential biomarker traits for affective disorders. Method: In this study we investigated the gray matter volume of the sgACC in 3 different patient groups: 40 MDD patients, of which 20 were medicated (MDDm) and 20 were unmedicated (MDDu), and 21 medicated BD patients, and compared them with 23 healthy volunteers. We examined GM volume alteration using highresolution 7T Magnetic Resonance Imaging (MRI) which produced quantitative maps of the spin-lattice relaxation time (T1). T1 maps provide high contrast between gray and white matter, and at 7 Tesla voxels with submillimeter resolution can be acquired in a reasonable scan time. We developed a semiautomatic segmentation protocol based on refined landmarks derived from previous volumetric studies using quantitative T1 maps as raw input data for automatic tissue segmentation of GM, WM and CSF (cerebrospinal fluid) tissue. The sgACC ROI was then superimposed on these tissue probability maps and traced manually by two independent raters (F.B., M.M.) following our semiautomatic segmentation protocol. Interrater reliability was calculated on a subset of 10 brain scans for each hemisphere, showing an Intra-Class Correlation coefficient (ICC) r = 0.96 for left sgACC and r = 0.84 for right sgACC respectively. In summary, we have developed a reproducible and reliable semi-automatic segmentation protocol to measure gray matter volume in the sgACC. Based on previous findings from meta-analyses on morphometric studies of the sgACC, we hypothesized that patients with MDD would have lower gray matter sgACC volumes compared to healthy subjects. Results: Post-hoc analysis revealed smaller subgenual volumes for the left hemisphere in both the medicated (MDDm) and non-medicated (MDDu) group versus healthy controls (p = .001, p = .008) respectively. For the right hemisphere, the (MDDu) and BD group exhibited significantly lower subgenual volumes than healthy controls (p < .001, p = .004) respectively. Conclusion: To our knowledge, this is the first morphometric MRI study using T1 maps obtained in high-resolution 7 Tesla MRI to compare MDD and BD patients with healthy controls. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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