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As a widely discussed topic in Western academic circles, post-productionism has become an important background for studying China's three agricultural problems. By carefully analyzing the origin, development, and practice of post-productionism, this study reveals the conceptual connotations and research status of post-productionism, which has theoretical value and practical significance for the study of China's three agricultural problems. The research through the research method of philology and the analysis of CiteSpace, the representative foreign core journals in Wed of Science with the theme of "post-productionism" were selected and summarized on the basis of data analysis.The research draws the following results: 1) This paper introduces the origin of post-productionism and summarizes the existing problems of agricultural production, rural ecology, and farmers' survival during the crisis, as well as the social expectation of the linear transformation of productionism to post-productionism. 2) On the basis of comprehensive research on the concept of "post-productionism," the conceptual domain of post-productionism is constructed from the four aspects of farmer's role, agricultural policy, farming technology and environmental impact, and three stages of conceptual research are proposed: the opposite stage, the coexistence stage and the subjective perspective stage, and compares it with the concept of "multifunctional agriculture," and points out the value of "paradigm shift" represented by post-productionism. 3) Comparing the post-productive rural practices of developed and developing countries, analyzing the common factors and regional differences between the post-productive rural practices of developed countries, sorting out the "post-productive phenomenon" of developing countries, and explaining the research objectives and necessity. On this basis, The paper further responds to the key question whether there is consistency between the "de-agriculturalization" in developing countries and the "post-productionism" in developed countries, and points out that there are some differences between the two in development stage, concept difference, connotation extension, expression form and fundamental value orientation. The conclusions are as following: 1) The development concept of Post-productionism is a positive response to productionism crises. Under the integration of common concepts, its global development path reflects the characteristics of "time-space difference" and "nonlinear transformation." Productionism and post-productionism are not "opposites," but will coexist and influence each other as two types of agricultural and rural management systems for a long time. Attention should also be paid to the fundamental role of change at the microactor level. 2) In relation to specific national conditions, the enlightenment of post-productionism in China's three rural problems is that we should pay attention to the research and judgment and grasp the opportunity of rural development, combine the overall promotion with key breakthroughs, continue to adhere to industrial revitalization as the goal, build a solid foundation for agricultural development, focus on promoting the development of secondary and tertiary industries, and focus on industrial integration. It is also necessary to deeply explore the multidimensional value of rural space, enrich the spatial attributes of rural areas, and promote rural development and urban-rural integration.

Background: Huangkui Lianchang Decoction (HLD) is a traditional Chinese herbal formula for treating ulcerative colitis (UC). However, its mechanism of action remains poorly understood. The Study aims to validate the therapeutic effect of HLD on UC and its mechanism by integrating network pharmacology, bioinformatics, and experimental validation. Methods: UC targets were collected by databases and GSE19101. The active ingredients in HLD were detected by ultra-performance liquid chromatography-tandem mass spectrometry. PubChem collected targets of active ingredients. Protein–protein interaction (PPI) networks were established with UC-related targets. Gene Ontology and Kyoto Encyclopedia (KEGG) of Genes and Genomes enrichment were analyzed for the mechanism of HLD treatment of UC and validated by the signaling pathways of HLD. Effects of HLD on UC were verified using dextran sulfate sodium (DDS)-induced UC mice experiments. Results: A total of 1883 UC-related targets were obtained from the GSE10191 dataset, 1589 from the database, and 1313 matching HLD-related targets, for a total of 94 key targets. Combined with PPI, GO, and KEGG network analyses, the signaling pathways were enriched to obtain IL-17, Toll-like receptor, NF-κB, and tumor necrosis factor signaling pathways. In animal experiments, HLD improved the inflammatory response of UC and reduced UC-induced pro-inflammatory factors such as Tumor Necrosis Factor Alpha (TNF-α), interleukin 1β (IL-1β), and interleukin 6 (IL-6). HLD suppressed proteins TLR4, MyD88, and NF-κB expression. Conclusions: This study systematically dissected the molecular mechanism of HLD for the treatment of UC using a network pharmacology approach. Further animal verification experiments revealed that HLD inhibited inflammatory responses and improved intestinal barrier function through the TLR4/MyD88/NF-κB pathway. [ABSTRACT FROM AUTHOR]

Objectives: Repetitive transcranial magnetic stimulation (rTMS) has been considered as an effective antidepressant treatment; however, the mechanism of its antidepressant effect is still unclear. Fluoxetine, a selective serotonin reuptake inhibitor antidepressant, may be neuroprotective. The objective of the present study was to evaluate the effect and underlying possible neuroprotective mechanism of rTMS and fluoxetine on abnormal behaviours in a depressive mouse model induced by chronic unpredictable mild stress (CUMS).Methods: After 28 days of CUMS exposure, mice were chronically treated with rTMS (10 Hz for 5 s per train, total 20 trains per day) and (or) fluoxetine (5 mg/kg/day, intraperitoneally) for 28 days targeting on the frontal cortex. After the behavioural tests, the protein expressions of glial fibrillary acidic protein (GFAP), brain-derived neurotrophic factor (BDNF) and tyrosine kinase B (TrkB) were measured by immunohistochemistry and (or) Western Blot.Results: The results showed rTMS and (or) fluoxetine attenuated the locomotion decrease, anxiety and depressive like behaviours in the CUMS-exposed mice.Conclusion: Our results suggest that both rTMS and fluoxetine could benefit the CUMS-induced abnormal behaviours including depressive-like behaviours, and the beneficial effects of rTMS as well as fluoxetine on depression might be partly related to their neuroprotective effect on attenuating astroglial activation and BDNF decrease [ABSTRACT FROM AUTHOR]